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Database: UniProt/TrEMBL
Entry: A8Z0A2_STAAT
LinkDB: A8Z0A2_STAAT
Original site: A8Z0A2_STAAT 
ID   A8Z0A2_STAAT            Unreviewed;       131 AA.
AC   A8Z0A2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   19-FEB-2014, entry version 42.
DE   RecName: Full=Regulatory protein Spx;
GN   Name=spxA; OrderedLocusNames=USA300HOU_0955;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O.Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y.,
RA   Igboeli O., Petrosino J., Tirumalai M., Uzman A., Fox G.E.,
RA   Cardenas A.M., Muzny D.M., Hemphill L., Ding Y., Dugan S., Blyth P.R.,
RA   Buhay C.J., Dinh H.H., Hawes A.C., Holder M., Kovar C.L., Lee S.L.,
RA   Liu W., Nazareth L.V., Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- FUNCTION: Interferes with activator-stimulated transcription by
CC       interaction with the RNA polymerase alpha-CTD. May function to
CC       globally reduce transcription of genes involved in growth- and
CC       development-promoting processes and to increase transcription of
CC       genes involved in thiol homeostasis, during periods of extreme
CC       stress (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
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DR   EMBL; CP000730; ABX28976.1; -; Genomic_DNA.
DR   RefSeq; YP_001574855.1; NC_010079.1.
DR   ProteinModelPortal; A8Z0A2; -.
DR   SMR; A8Z0A2; 1-118.
DR   STRING; 451516.USA300HOU_0955; -.
DR   EnsemblBacteria; ABX28976; ABX28976; USA300HOU_0955.
DR   GeneID; 5777570; -.
DR   KEGG; sax:USA300HOU_0955; -.
DR   PATRIC; 19596948; VBIStaAur36919_0996.
DR   eggNOG; COG1393; -.
DR   HOGENOM; HOG000059715; -.
DR   KO; K16509; -.
DR   OMA; RPIIMDD; -.
DR   OrthoDB; EOG6WQDCS; -.
DR   ProtClustDB; PRK01655; -.
DR   BioCyc; SAUR451516:GJQ4-974-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.30.10; -; 1.
DR   HAMAP; MF_01132; SpxA; 1.
DR   InterPro; IPR006660; Arsenate_reductase-like.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR023731; Tscrpt_reg_Spx.
DR   InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR   Pfam; PF03960; ArsC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01617; arsC_related; 1.
DR   PROSITE; PS51353; ARSC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Disulfide bond; Redox-active center;
KW   Transcription; Transcription regulation.
FT   DISULFID     10     13       Redox-active (By similarity).
SQ   SEQUENCE   131 AA;  15441 MW;  89F67A54666699BF CRC64;
     MVTLFTSPSC TSCRKAKAWL QEHDIPYTER NIFSEHLTID EIKQILKMTE DGTDEIISTR
     SKTYQKLNVD IDSLPLQDLY SIIQDNPGLL RRPIILDNKR LQVGYNEDEI RRFLPRKVRT
     FQLQEAQRMV D
//
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