ID A8Z0A2_STAAT Unreviewed; 131 AA.
AC A8Z0A2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 01-MAY-2013, entry version 38.
DE RecName: Full=Regulatory protein spx;
GN Name=spxA; OrderedLocusNames=USA300HOU_0955;
OS Staphylococcus aureus (strain USA300 / TCH1516).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=451516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300 / TCH1516;
RX PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA Mason E.O.Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y.,
RA Igboeli O., Petrosino J., Tirumalai M., Uzman A., Fox G.E.,
RA Cardenas A.M., Muzny D.M., Hemphill L., Ding Y., Dugan S., Blyth P.R.,
RA Buhay C.J., Dinh H.H., Hawes A.C., Holder M., Kovar C.L., Lee S.L.,
RA Liu W., Nazareth L.V., Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT "Subtle genetic changes enhance virulence of methicillin resistant and
RT sensitive Staphylococcus aureus.";
RL BMC Microbiol. 7:99-99(2007).
CC -!- FUNCTION: Interferes with activator-stimulated transcription by
CC interaction with the RNA polymerase alpha-CTD. May function to
CC globally reduce transcription of genes involved in growth- and
CC development-promoting processes and to increase transcription of
CC genes involved in thiol homeostasis, during periods of extreme
CC stress (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
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DR EMBL; CP000730; ABX28976.1; -; Genomic_DNA.
DR RefSeq; YP_001574855.1; NC_010079.1.
DR ProteinModelPortal; A8Z0A2; -.
DR SMR; A8Z0A2; 1-118.
DR STRING; 451516.USA300HOU_0955; -.
DR EnsemblBacteria; ABX28976; ABX28976; USA300HOU_0955.
DR GeneID; 5777570; -.
DR KEGG; sax:USA300HOU_0955; -.
DR PATRIC; 19596948; VBIStaAur36919_0996.
DR eggNOG; COG1393; -.
DR HOGENOM; HOG000059715; -.
DR KO; K16509; -.
DR OMA; RPIIMDD; -.
DR ProtClustDB; PRK01655; -.
DR BioCyc; SAUR451516:GJQ4-974-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR HAMAP; MF_01132; SpxA; 1; -.
DR InterPro; IPR006660; Arsenate_reductase-like.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR023731; Tscrpt_reg_Spx.
DR InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR Pfam; PF03960; ArsC; 1.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR01617; arsC_related; 1.
DR PROSITE; PS51353; ARSC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Disulfide bond; Redox-active center;
KW Transcription; Transcription regulation.
FT DISULFID 10 13 Redox-active (By similarity).
SQ SEQUENCE 131 AA; 15441 MW; 89F67A54666699BF CRC64;
MVTLFTSPSC TSCRKAKAWL QEHDIPYTER NIFSEHLTID EIKQILKMTE DGTDEIISTR
SKTYQKLNVD IDSLPLQDLY SIIQDNPGLL RRPIILDNKR LQVGYNEDEI RRFLPRKVRT
FQLQEAQRMV D
//
