ID A9BGP3_PETMO Unreviewed; 164 AA.
AC A9BGP3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE RecName: Full=3-isopropylmalate dehydratase small subunit;
DE EC=4.2.1.33;
DE AltName: Full=Alpha-IPM isomerase;
DE AltName: Full=Isopropylmalate isomerase;
GN Name=leuD; OrderedLocusNames=Pmob_1587;
OS Petrotoga mobilis (strain DSM 10674 / SJ95).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Petrotoga.
OX NCBI_TaxID=403833;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10674 / SJ95;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D.,
RA Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Noll K., Richardson P.;
RT "Complete sequence of Petroga mobilis SJ95.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC isopropylmalate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC -!- SUBUNIT: Heterodimer of LeuC and LeuD (By similarity).
CC -!- SIMILARITY: Belongs to the LeuD family. LeuD type 2 subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CP000879; ABX32283.1; -; Genomic_DNA.
DR RefSeq; YP_001568606.1; NC_010003.1.
DR ProteinModelPortal; A9BGP3; -.
DR STRING; 403833.Pmob_1587; -.
DR EnsemblBacteria; ABX32283; ABX32283; Pmob_1587.
DR GeneID; 5757902; -.
DR KEGG; pmo:Pmob_1587; -.
DR PATRIC; 22920984; VBIPetMob40494_1709.
DR eggNOG; COG0066; -.
DR HOGENOM; HOG000222940; -.
DR KO; K01704; -.
DR OMA; ELATHAM; -.
DR BioCyc; PMOB403833:GH51-1642-MONOMER; -.
DR UniPathway; UPA00048; UER00071.
DR GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:HAMAP.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.20.19.10; -; 1.
DR HAMAP; MF_01032; LeuD_type2; 1; -.
DR InterPro; IPR015937; Acoase/IPM_deHydtase.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR InterPro; IPR011827; IsopropMal_deHydtase_ssu.
DR InterPro; IPR011824; IsopropMal_deHydtase_ssu_bac.
DR PANTHER; PTHR11670; PTHR11670; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR SUPFAM; SSF52016; Aconitase/3IPM_dehydase_swvl; 1.
DR TIGRFAMs; TIGR02084; leud; 1.
DR TIGRFAMs; TIGR02087; LEUD_arch; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW Complete proteome; Leucine biosynthesis; Lyase.
SQ SEQUENCE 164 AA; 18373 MW; 64F3E4948D1886FF CRC64;
MKFRGRVFKY GDNVDTDVII PARYLNNPEP EILAQHCMED IDKDFVKKVQ KGDIIVAGRN
FGSGSSREHA PLSIKAAGVS CVIAESFARI FYRNAINIGL PILISKEASH NIQDGSEIEV
DLDNGIIKDL KNKKEYYSEK YPKFLQEIIS SGGLIEKIKK EVAQ
//
