ID A9JRJ1_XENTR Unreviewed; 1350 AA.
AC A9JRJ1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=LOC100135076 protein {ECO:0000313|EMBL:AAI55682.1};
DE SubName: Full=Tenascin-R precursor {ECO:0000313|RefSeq:NP_001107287.1};
GN Name=tnr {ECO:0000313|RefSeq:NP_001107287.1,
GN ECO:0000313|Xenbase:XB-GENE-948286};
GN Synonyms=janusi {ECO:0000313|RefSeq:NP_001107287.1}, LOC100135076
GN {ECO:0000313|EMBL:AAI55682.1}, restrictin
GN {ECO:0000313|RefSeq:NP_001107287.1}, tenascin-r
GN {ECO:0000313|RefSeq:NP_001107287.1}, xtnr
GN {ECO:0000313|RefSeq:NP_001107287.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI55682.1};
RN [1] {ECO:0000313|RefSeq:NP_001107287.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI55682.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI55682.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001107287.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR EMBL; BC155681; AAI55682.1; -; mRNA.
DR RefSeq; NP_001107287.1; NM_001113815.1.
DR GeneID; 100135076; -.
DR KEGG; xtr:100135076; -.
DR AGR; Xenbase:XB-GENE-948286; -.
DR CTD; 7143; -.
DR Xenbase; XB-GENE-948286; tnr.
DR OMA; QCVCDSD; -.
DR OrthoDB; 5489847at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR CDD; cd00063; FN3; 9.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF6; TENASCIN-R; 1.
DR Pfam; PF18720; EGF_Tenascin; 3.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 9.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 9.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001107287.1}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1350
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001107287.1"
FT /id="PRO_5033207420"
FT DOMAIN 321..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 414..504
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 505..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 593..684
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 685..774
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 775..861
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 862..951
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 952..1037
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1038..1125
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1124..1339
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
SQ SEQUENCE 1350 AA; 149693 MW; 753F62B914BC016B CRC64;
MGSEGVSSAL GPLQVGVHLI LLACLTRRSQ CQSELTGQTP RLDIQVDKGG NMTDHGIENK
QNPMVFNHVY NFNVPLSFPC TLEPETPEDG SWVTQQTENT ADAGSQITFT HSIRVPQRLC
QCYTTPHAVQ HLLSRIEALE REVMLLRERC NDRACQDAEA TGLTEFAPPC SGHGNFTVDS
CICNQGWGGE NCSEPLCPLE CSGRGTCIEG MCVCEPDYTG EWCTDLLCPE ECSPHGLCQD
GQCVCQDPYI GIGCTELRCP GDCLGKGRCA NGTCVCQDGY AGEDCGRMWC INACSGRGQC
QDGVCECEEG YSGQDCSEVA PPVDFSVTAV GDHWMDLAWE GTTAVTEYVI SYQPAVPGEW
GTQQRLQQRV PGDWSSVTIR ELEPGVTYNI SVCSVISDII SEPASITIST HISSPRGLNF
MEVTQTSVEV HWDPPVFPLD GWEISFTPKN NEGGLTVQLP SSVTSFNQTG LKPGEEYTVS
IISLKDQARS PATSGSISTD IDGPTNILVR DVTDTVAFVE WTPARAKLDF MQLDYGPING
EGEKTTFRLQ PPLSQYSMQV LRPGSQYEIS IRGVRGDTES EPVRATFTTE LDAPKNLRVI
SHASSTLELE WDNSEAEGEG YRVVYSTLAG DQYHELIVPR NYGQTTKATL TDLIPGTEYG
IGISAIRYNL KSAPATMNAR TELDSPTDLM VTGSTDKSIS LTWTKARGPI DHYRISFTPS
SGMASEVTVP SDISQYELSE LEPGTEYTIS IFAERGRQQS KETTIDAFTG FRPITQLHFS
AVTAYSVNVS WTDPSPPPDQ FILTYNPIDS KDPLQLFLDP SLRQTRLSAL QPSTEYMVTL
LPVHGTVRAE LVEGTVTTGV APPMDLSVIN VTENSLAVVW RPPPSSLHHY RLTYQSTKGR
MDSVVIGNDQ TRYTLANLMP NTEYKISLRS VRGREESERV GIVSWTAVDP PYGLRTSNIT
ATEALLHWEP PRSEVESYVI IVTHHAGSGE TILVDGESIE FQLQNLLPRT NYSVTLSANF
GHQTSRSVGV SFTTILDPPM NLTATEVART SALISWQPPI SPIENYILTY KSANESRKEL
IVDAEDTWIR LEGLLESTEY TVSILSVQNG ERSSVTHTVF TTGGRVFSYP QDCAQHMLNG
DNQSGVYYIY INGDMSQSVP VYCDMATDAG GWIVFQRRQN GLTDFFRKWA DYRVGFGNLE
DEFWLGLDTL HQVTSQGRYE LRIDMRDGQE AVYAYYNKFN IGDARSLYKL RIGDFNGTSG
DSLTYHQGRP FSTKDRDNDV AVTNCASSYK GAWWYKNCHR TNLNGKYGES RHSQGINWYH
WKGHEFSIPF VEMKMRPYNH RTMKKRSLQL
//
