ID   A9UR24_MONBE            Unreviewed;       517 AA.
AC   A9UR24;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   03-APR-2013, entry version 38.
DE   RecName: Full=Pyruvate kinase;
DE            EC=2.7.1.40;
GN   ORFNames=14293;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellida; Codonosigidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Sequencing J.G., Bork P., Lim W.A.,
RA   Manning G., Miller W.T., McGinnis W., Shapiro H., Tjian R.,
RA   Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the
RT   origin of metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 5/5.
CC   -!- SIMILARITY: Belongs to the pyruvate kinase family.
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DR   EMBL; CH991544; EDQ92173.1; -; Genomic_DNA.
DR   RefSeq; XP_001743459.1; XM_001743407.1.
DR   ProteinModelPortal; A9UR24; -.
DR   SMR; A9UR24; 7-517.
DR   STRING; 81824.JGI14293; -.
DR   GeneID; 5888553; -.
DR   KEGG; mbr:MONBRDRAFT_14293; -.
DR   eggNOG; COG0469; -.
DR   KO; K00873; -.
DR   OMA; VKMMATI; -.
DR   UniPathway; UPA00109; UER00188.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR   GO; GO:0004743; F:pyruvate kinase activity; IEA:EC.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.40.33.10; -; 1.
DR   Gene3D; 3.20.20.60; -; 2.
DR   Gene3D; 3.40.1380.20; -; 1.
DR   InterPro; IPR001697; Pyr_Knase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase.
DR   InterPro; IPR011037; Pyrv_Knase-like_insert_dom.
DR   InterPro; IPR015794; Pyrv_Knase_a/b.
DR   InterPro; IPR018209; Pyrv_Knase_AS.
DR   InterPro; IPR015793; Pyrv_Knase_brl.
DR   InterPro; IPR015795; Pyrv_Knase_C.
DR   InterPro; IPR015806; Pyrv_Knase_insert_dom.
DR   PANTHER; PTHR11817; PTHR11817; 1.
DR   Pfam; PF00224; PK; 1.
DR   Pfam; PF02887; PK_C; 1.
DR   PRINTS; PR01050; PYRUVTKNASE.
DR   SUPFAM; SSF50800; PK_B_barrel_like; 1.
DR   SUPFAM; SSF52935; Pyruvate_kinase; 1.
DR   SUPFAM; SSF51621; Pyrv/PenolPyrv_Kinase_cat; 1.
DR   TIGRFAMs; TIGR01064; pyruv_kin; 1.
DR   PROSITE; PS00110; PYRUVATE_KINASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome;
KW   Transferase.
SQ   SEQUENCE   517 AA;  55720 MW;  CC33AAA35A2F2DE8 CRC64;
     MARPSQQEAQ AAMTGLQMRS SLNIYSDPAH ARKTGIICTI GPASRSVELL TSLMKAGMNI
     VRLNFSHGTH EYHAGTIANA REAANAHNRP IAIALDTKGP EIRTGLLEGF NENPRLELEL
     GQGSQITVTT DDAFAEKCTA DVLYVDYKNI TKVMKPGNLI YVDDGLISLQ VDSISSDSMK
     CTVVNSGKLG SKKGVNLPNV KVDLPAISEK DKSDLTFGVE QGVDMIFASF IRKASDVQAI
     REHLGEAGKN IKIICKIENH EGVQNFDEIL SVVDGVMVAR GDLGIEIPAE KVFLAQKMMI
     AKCNLAGKPV ICATQMLESM IKAPRPTRAE GSDVANAVLD GADCVMLSGE TAKGDYPVEA
     VKMMASIAVE AEAAVNLRDL REEMRMLTPK PTKTTETCAT AAVDASISSQ AAAIICLTIS
     GRTARLISKW KPICPVVAVT RQHSVARQMH LHFGVSPMCY DTSKKDTWAG DVDKRFSWAM
     ENGKALKLFK SGDVVVGVHG WQTGPGHTNT IRMLVVP
//