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Database: UniProt/TrEMBL
Entry: A9UWS0_MONBE
LinkDB: A9UWS0_MONBE
Original site: A9UWS0_MONBE 
ID   A9UWS0_MONBE            Unreviewed;      1016 AA.
AC   A9UWS0;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 101.
DE   SubName: Full=PI3K-CA alpha {ECO:0000313|EMBL:EDQ90091.1};
GN   Name=PI3K-CA_alpha {ECO:0000313|EMBL:EDQ90091.1};
GN   ORFNames=MONBRDRAFT_18656 {ECO:0000313|EMBL:EDQ90091.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ90091.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ90091.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00879}.
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DR   EMBL; CH991548; EDQ90091.1; -; Genomic_DNA.
DR   RefSeq; XP_001744858.1; XM_001744806.1.
DR   AlphaFoldDB; A9UWS0; -.
DR   STRING; 81824.A9UWS0; -.
DR   EnsemblProtists; EDQ90091; EDQ90091; MONBRDRAFT_18656.
DR   GeneID; 5890395; -.
DR   KEGG; mbr:MONBRDRAFT_18656; -.
DR   eggNOG; KOG0904; Eukaryota.
DR   InParanoid; A9UWS0; -.
DR   OMA; WSEWLNY; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:GO_Central.
DR   GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR   GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05165; PI3Kc_I; 1.
DR   Gene3D; 3.10.20.770; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR002420; PI3K-type_C2_dom.
DR   InterPro; IPR003113; PI3K_ABD.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR000341; PI3K_Ras-bd_dom.
DR   InterPro; IPR015433; PI_Kinase.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   PANTHER; PTHR10048:SF118; PI-3 KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00792; PI3K_C2; 1.
DR   Pfam; PF02192; PI3K_p85B; 1.
DR   Pfam; PF00794; PI3K_rbd; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   SMART; SM00142; PI3K_C2; 1.
DR   SMART; SM00144; PI3K_rbd; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS51547; C2_PI3K; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51544; PI3K_ABD; 1.
DR   PROSITE; PS51546; PI3K_RBD; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..88
FT                   /note="PI3K-ABD"
FT                   /evidence="ECO:0000259|PROSITE:PS51544"
FT   DOMAIN          169..258
FT                   /note="PI3K-RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51546"
FT   DOMAIN          310..465
FT                   /note="C2 PI3K-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51547"
FT   DOMAIN          486..662
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          725..1003
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1016 AA;  116795 MW;  01E0503D4A91085F CRC64;
     MESVICLLPT GMIVKLDVAI GGSQTYNDIK NNVWQAASGL PFFHELKQPQ SYGFSAVGTD
     GEMLELHDDD LFDRTRLYTP WLKVCSRGSK EEQRFNLDIS RLIGKQLSEF DFIRDPEVVA
     FRQSILSICQ NAQKLRQSEG IEGAALHRFP PNTISSPFPQ HLKAKLNKKE QFILMVYFSS
     DQASKTVCDI NQTPDELIKV IVRKGRVGQK LGSDNPTEYV LKVHGRDEYL LGKFRMGDYK
     YVRHCLAHGY TKTDLSDHNC RLVLERRDDM YKKIPQANTD KMLMSKSALR LEEPTPANPA
     QAMTWFGAEA DSKFSVLIRS AHNVITGKLF SIGIKACVFL GDKPISDEEA TRFVPPEENM
     SWAQPIEFDL AIKDLPRDAR LCIALFGVWA NPLKVKKRKN FRNEYVLAWT NISIMDFRGF
     LRQGEYTLAT WTVEDGENAA LFNPLGTTTT NPTQGSSPTL TIEFTKFQRE LCYPTSDYTQ
     QQRIYEGTTH PLEPNARERL ERLILADPLY AFTPDDFDLL RRYRDNFKEN PAALSKCLRA
     VEWSNHEYVW DVEEMLSTWA AVRPEEALEL LDSGFSDRAI RSHAVQRLEP MEDDQLLEYL
     LQLVQVLKYE TYLDNDLSRF LLKRALQSQR VGHFFFWFLR SEIHNPECGV RFGLLLEAYC
     RGCGSHFPDL HAQVQVLNQM EDIADTLKDK NIKDKDKKQC AIELVEKSTF PAFQLPLEPS
     LRLEGVKVRK VFDSAQRPLW IEFDNADKMG NSFNVMFKNG DDLRQDMLTL QLIAIMDRLW
     QEQGLDLQMT PYACLSTGDM VGLLEMVMGA KTLWQIQGKI KNVMLNDDTL NNFLKASNAE
     TPAYDEACNN FMLSCAGYSV ATYVLGVADR HNDNIMLKET GQFFHIDFGH FLGNWKYKFG
     IQRERVKFIL VPEFIHIITR GEGQRSKKWV EFKDTCKQAF RIVRQNASLF INLLNMMLST
     GIPELTTHKD VSYLRETLFL DDTEEQAVAK FEDEIAIAIR DSNTVKINWA FHGYKH
//
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