ID A9UWS0_MONBE Unreviewed; 1016 AA.
AC A9UWS0;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE SubName: Full=PI3K-CA alpha {ECO:0000313|EMBL:EDQ90091.1};
GN Name=PI3K-CA_alpha {ECO:0000313|EMBL:EDQ90091.1};
GN ORFNames=MONBRDRAFT_18656 {ECO:0000313|EMBL:EDQ90091.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ90091.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ90091.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00879}.
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DR EMBL; CH991548; EDQ90091.1; -; Genomic_DNA.
DR RefSeq; XP_001744858.1; XM_001744806.1.
DR AlphaFoldDB; A9UWS0; -.
DR STRING; 81824.A9UWS0; -.
DR EnsemblProtists; EDQ90091; EDQ90091; MONBRDRAFT_18656.
DR GeneID; 5890395; -.
DR KEGG; mbr:MONBRDRAFT_18656; -.
DR eggNOG; KOG0904; Eukaryota.
DR InParanoid; A9UWS0; -.
DR OMA; WSEWLNY; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:GO_Central.
DR GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05165; PI3Kc_I; 1.
DR Gene3D; 3.10.20.770; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR PANTHER; PTHR10048:SF118; PI-3 KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF02192; PI3K_p85B; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00144; PI3K_rbd; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..88
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
FT DOMAIN 169..258
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 310..465
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 486..662
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 725..1003
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1016 AA; 116795 MW; 01E0503D4A91085F CRC64;
MESVICLLPT GMIVKLDVAI GGSQTYNDIK NNVWQAASGL PFFHELKQPQ SYGFSAVGTD
GEMLELHDDD LFDRTRLYTP WLKVCSRGSK EEQRFNLDIS RLIGKQLSEF DFIRDPEVVA
FRQSILSICQ NAQKLRQSEG IEGAALHRFP PNTISSPFPQ HLKAKLNKKE QFILMVYFSS
DQASKTVCDI NQTPDELIKV IVRKGRVGQK LGSDNPTEYV LKVHGRDEYL LGKFRMGDYK
YVRHCLAHGY TKTDLSDHNC RLVLERRDDM YKKIPQANTD KMLMSKSALR LEEPTPANPA
QAMTWFGAEA DSKFSVLIRS AHNVITGKLF SIGIKACVFL GDKPISDEEA TRFVPPEENM
SWAQPIEFDL AIKDLPRDAR LCIALFGVWA NPLKVKKRKN FRNEYVLAWT NISIMDFRGF
LRQGEYTLAT WTVEDGENAA LFNPLGTTTT NPTQGSSPTL TIEFTKFQRE LCYPTSDYTQ
QQRIYEGTTH PLEPNARERL ERLILADPLY AFTPDDFDLL RRYRDNFKEN PAALSKCLRA
VEWSNHEYVW DVEEMLSTWA AVRPEEALEL LDSGFSDRAI RSHAVQRLEP MEDDQLLEYL
LQLVQVLKYE TYLDNDLSRF LLKRALQSQR VGHFFFWFLR SEIHNPECGV RFGLLLEAYC
RGCGSHFPDL HAQVQVLNQM EDIADTLKDK NIKDKDKKQC AIELVEKSTF PAFQLPLEPS
LRLEGVKVRK VFDSAQRPLW IEFDNADKMG NSFNVMFKNG DDLRQDMLTL QLIAIMDRLW
QEQGLDLQMT PYACLSTGDM VGLLEMVMGA KTLWQIQGKI KNVMLNDDTL NNFLKASNAE
TPAYDEACNN FMLSCAGYSV ATYVLGVADR HNDNIMLKET GQFFHIDFGH FLGNWKYKFG
IQRERVKFIL VPEFIHIITR GEGQRSKKWV EFKDTCKQAF RIVRQNASLF INLLNMMLST
GIPELTTHKD VSYLRETLFL DDTEEQAVAK FEDEIAIAIR DSNTVKINWA FHGYKH
//