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Database: UniProt/TrEMBL
Entry: A9VUL4_BACWK
LinkDB: A9VUL4_BACWK
Original site: A9VUL4_BACWK 
ID   A9VUL4_BACWK            Unreviewed;      4968 AA.
AC   A9VUL4;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   25-OCT-2017, entry version 71.
DE   SubName: Full=Amino acid adenylation domain {ECO:0000313|EMBL:ABY46585.1};
GN   OrderedLocusNames=BcerKBAB4_5617 {ECO:0000313|EMBL:ABY46585.1};
OS   Bacillus weihenstephanensis (strain KBAB4).
OG   Plasmid pBWB401 {ECO:0000313|EMBL:ABY46585.1,
OG   ECO:0000313|Proteomes:UP000002154}.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730 {ECO:0000313|EMBL:ABY46585.1, ECO:0000313|Proteomes:UP000002154};
RN   [1] {ECO:0000313|EMBL:ABY46585.1, ECO:0000313|Proteomes:UP000002154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4 {ECO:0000313|EMBL:ABY46585.1,
RC   ECO:0000313|Proteomes:UP000002154};
RC   PLASMID=Plasmid pBWB401 {ECO:0000313|Proteomes:UP000002154};
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B.,
RA   Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H.,
RA   Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P.,
RA   Weissenbach J., Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; CP000904; ABY46585.1; -; Genomic_DNA.
DR   RefSeq; WP_012259873.1; NC_010180.1.
DR   ProteinModelPortal; A9VUL4; -.
DR   EnsemblBacteria; ABY46585; ABY46585; BcerKBAB4_5617.
DR   KEGG; bwe:BcerKBAB4_5617; -.
DR   HOGENOM; HOG000229991; -.
DR   OMA; NRQHWNQ; -.
DR   Proteomes; UP000002154; Plasmid pBWB401.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 4.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 4.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 4.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002154};
KW   Plasmid {ECO:0000313|EMBL:ABY46585.1}.
FT   DOMAIN     1005   1072       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2048   2115       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3111   3177       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4629   4696       Carrier. {ECO:0000259|PROSITE:PS50075}.
SQ   SEQUENCE   4968 AA;  566865 MW;  0A681B2F03EF8BD9 CRC64;
     MRSDLHAKLS SLSPEKRAWL QKRMQKKENK EALPLSYAQQ RLWFMDRFNP NSSLYNIPTV
     WHLKGNWIPE ALEKGFNRLI ERHESLRTVF KEVGEQPVQQ IVEFLPRALP VRDYSQLPLE
     VKEKEVDSLI AREAQEPFDL MNGPLIRNQL VQLGKDEWLL LCTMHHIISD AWSIGILMNE
     LLTFYEEETG GNPAKLSSLS IQYADFAKWQ KEWLQGDVLN RQLTYWEEEL SGELPILQLP
     VDRPRPVTQT YAGDTHHVIF PYRLLNQLKD ISRQEGSTLF MTLMAAYQSF LARYTGQKDI
     LVGSPIANRN HKGVEGLIGF FVNTLVYRSD LSGTPTFREI LNQTKKKALK AYEYQDIPFE
     KVVEAVQPER SMSHSPIFQT MFTLQNIKQE RLDLSGRSIE MVESNMSIVK FDLSLTAYEV
     EEGLFVSFEY NTDLFDSSTV ARMAGHFENW LNEIAYHPDE SYTKLSMLSD TEQKQLLEEW
     NDTDVVYGHE YMIHELFEQQ VARTPDAVAV VYEGGKLTYQ ELNEKSNQLA HYLQKRGIGP
     ESLVGICVER SPEMIIGLFG ILKAGGAYVP LDPSYPENRL RYILENSQIQ VLLTKEALQD
     WLPKDIQAIC LDRDQVMISK ESNLAPVSGV TANNLAYIIY TSGSTGNPKG VMIEHHSVIN
     RLQWMQKKYP LSEEDTILQK TPFSFDVSVW ELFWWSFVGA RVCLLQPGGE KDPAVIEEYI
     ERYRVTTMHF VPSMLSTFLD YMEQYNSKRD ESSLNQVFTS GEALNTEQVR RFKGVFYDVQ
     QTKLINLYGP TEATVDVTYY DCDLEKEPML IPIGRPIDNT ELYVLDQYQQ VVPIGVAGEL
     YLGGVGLARG YFNRPELTTE RFIPHPFKEG ERLYRTGDLV RYMNDRNLEY IGRIDNQVKI
     RGFRIELGEI EAALHDHSSV KEAVVLVKED RPGDKQLVAY VVGEGDTGEW REYLKKQLPN
     YMVPAYFFQV ESMPLTPNGK VDRKALLELE AQFISEDITS SRTPVEELIV SVWSKVLGIR
     NISVQDSFFE IGGHSLLATQ VVSRLQEIFQ IELPVRELFE YATVESLAKR LDQLRKGDRK
     RDIPPLMPME RGETIPLSYA QQRLWFIDQF TPNSALYNMP IVCRLTGSWL PEALETGWNQ
     LIERHESLRT VFHEVNGQPV QQIEPYAFRL IPKTDLTMLS PEGREEEVKR LIQQETEMPF
     DLGEGPLIRT SILQVGEEEW ILLCTLHHII SDGWSMEVLL EEWMAFYEKA TDGKIAELEP
     LPVQYADFAQ WQKGWLKAEV LDQQLQYWKE ELSGELPVLQ LPMDRPRPAI QTHDGSTYTL
     VLPSALHDKL NEFSLQEGAT LFMTLLAAYQ SFLSRYTGQE DILVGSPIAN RNYREIEGLI
     GFFVNTLVYR ANLSGRPTFQ DVLSQVRQKA LKAYEYQDIP FEKIVEVVQP ERSTSHSPIF
     QTMFILQNLK QEFPVLSGRS IEMIESHSPI AKFDLSVMVA ETEEGVRFTF EYNKDLFNAT
     TIERMAGHFE KWLHEVSHHP KNPLHSLSML SEPERTLLLE TWNDTVMEMP PQGLICDRFE
     EQVAKRPEAI AVVDQTKDWT YGELDAQANQ LANVLQRKGV APESVVGVYL PRSAELMVSL
     LGILKAGGAY VVLDPLYPKS RLEYMIEDAG IQFVVTAEGQ EGLFEQVEMV RLEELTVESV
     IAPTRQINPE NLAYIVYTSG STGKPKGVMI EYRSLMNMVS WHHEVYRITA EDRATQIAGI
     AFDSAVQEIW PYLTAGAALY LSTEELRINP EALRDWLIDS RITASFAPTP ILERLLKLSW
     PDKTDLRFII TGGDQLTQYP SNDIPFAVIN QYGPSENTVV TTDCYVPVGV TTGTPSIGRP
     IANTEVYVLD SHLQLVPSGV IGDLYIGGKS LARGYANRPD LTKEKFISHP FKSGERLYYT
     GDKASYLSDG ALQFHGRIDD QVKIRGFRIE LGEIEAVLQA HSSVKEAVVL VREDDPGDKR
     LVAYVVGEGS VQEWREHLQT HLPNYMVPTN FIEMEFLPLT PNGKLDLKAL PIPSKLSTEN
     TVHARTPLEE LIASVWSQVL GIENIGVQDS FFELGGHSLL ATQVVSRLQE VFQIKLPVRE
     LFEYSTVEAL AKRLDQLRKG GKKREIPPLM PMERGNAIPL SYAQQRLWFI DQFTPNSALY
     NMPMVCRLTG NWLLEALEVG WNQLIERHES LRTVFHEVDG HPVQKIQPYT FRSLPQIDLT
     KISPEERERE VEQWIQTEVE SPFDLEQGPL FRGQIVKISE EEWVLLCNMH HIISDGWSME
     ILLQEWMAFY EEAIGEKPAD LAPLPVQYAD FAQWQREWLI DEVLNQPLAY WKEELSGELP
     VLMLPMDRPR PPVQTHHGLT HNVLLSRSLL DKLNELSRQE GATLFMTLLA SYQSFLARYT
     GQSDILVGSP IANRNYREIE GLIGFFVNTL VYRADLSGAP AFQELLSQVR IKALKAYEYQ
     DVPFEKIVEV IQPERSTSYS PIFQTMFTLQ NTGQELPKLH GRSIEVMDSH ASIAKFDLSL
     TAAEVEEGLL LTFVYRTDLF DSLTIESIAE NFGNWLNLIV EQPDKSLAKL PILSGLQQKQ
     LEEWNNNAVA YPQEFGIHQL YEEQVNRTPD AVAVVDEKQQ LTYRELNEKA NQLAHYLQKC
     GIGSESLVGL CFQRSAEMIV GLMGILKAGA AYVPLDPSYP ESRLRYILED TGIQVLVTNE
     ALEGWITEEI KTVCLDRDKA MISRESTLSP ICEVTGENLA YVIYTSGSTG NPKGVMVEHH
     NVIRLFKSTE CWYQFDEKDT WTLFHSYAFD FSVWEIWGAL LHGGRLIVVP YWISRSPKDF
     YQLLVKEKVT VLNQTPSAFR QLIQVCEQED EKKDLHLRYV IFGGEALDPT SLVPWFQRYG
     GQEPQLINMY GITETTVHVT YYPITQDDVQ HASRSNIGKQ IPDLEVYVLD ACQQPVPIGV
     AGELFIGGAG LARGYLNRSE LTAERFIPHP FSSDPGARLY RTGDLARYLP DGNLDYLGRI
     DHQVKIRGFR IELGEIESAL NAHVSIKEAV VIVREDQPGD KRLVAYVVGD GNVGEWRDYL
     KAELPSHMVP SGFVMMEAIP LTANGKVDRK ALPVPEERKI ESECVATRNG NEETLATIWK
     QVLGIKKVGI HDNFFEIGGD SILSIQIVSR AKQAGLQLTP KQMFEHQTIA ELAQVVNEER
     GVQAEQGVIT GELILTPIQQ WFFAQDHPNP HHWNQSMFFR TKERLDIVLL EKAVRTLLIH
     HDALRLRYER LPNGAWKQWN EGIEEQSTLT VISLDEVPQA EWHQVIQAEI DTAQASLHLH
     AGPLMRMVYF DEGEKRAGRL FWVIHHLAVD GVSWRILLED LQTAYNQASQ DQMIQLPTKS
     TSFKAWSEKL HHYAEAGIVQ EVRDYWEQQS EQEVAMLPVD TTLEVPANTG TEEITVVLDE
     KETRTLLKEI SSTHRVQINE VLLTALVQAT AVWTGHPALT VDLEGHGREE IIEDVDLSRT
     VGWFTSIYPV HLNITGADTP IAALKAVKEQ VRKIPNKGVD HGILRYLNTT ICEQWGSQHT
     PSISFNYLGQ FDQMFSDDAI LIPENGFKRL DHASGSKRSH LIDVIGMVTD GKLQFTWVYN
     VGQYAKSTIQ SIAENMLHQL SKLIQSAGGE SALTVSDFVM ANLDQASLTK VLTKMNRGNN
     YPITDLYPLS PLQEGMIFHT LHDQGEEHVA PYIVQLSFMI RGELDIATFE QAWKSVIQRH
     EIFRSAFLWD EVEEPLQVVY ESVPFKVNVE DWRTLTAEEK EEKRKAFLAL DRKQAFLFDK
     APLMRVTVIQ EGEEEYRIVW THHHILLDGW SLPLVFNELL TVYQKRMNGE AVHLPNSSPY
     KKYIQWLREQ NQEQAEQFWR EKLKGFTAPT LLGLESKEQE KGYTEKVTYL SEEQTQALQN
     WAKRNRLTLN TVIQGAWAYL MSRYSGEDEI VYGVTSSGRP TEIIDVENIV GPFITTSPTR
     IQLIDNIKVM DWLLKIQEEE IERRQYEYAS LTEIQGWSEI PRGTPLFHSL YVFENYPVKE
     GSSGNLEIGE LEGVEQTHYP LGLTVVPESQ LLLKLKYDRS KFNGLTIERM LGHLSQVLKQ
     MIENVDQTLS ELVYVTEIEQ KQLLEEWNDN AAAYPRESVI HKLFEDQVDR TPDAVAVVDE
     NQRLTYRELN EKANQLAHYL QKMGIGTESL VGLCFQRSVE MIVGLMGILK AGSAYVPLDP
     SYPESHLRYI LEDTGIQILV TNEVSQGWMP EEVETVCLDR DQAMISQENT LSPICKVTGE
     NLAYVIYTSG STGNPKGVMV QHHSVLNLSY GLQKEVFSHR AHDNMRVGLN ASIAFDSSVK
     QLQMLLYGSS LYIISTEVRS DPQQFISYIR ENKLEMFDIT PSLLQLLIDE GLLETNDSVH
     VPSKVLVGGE AIMPSLWEQL VENDHIHFYN VYGPTECTVD ATCYRIKKDS KRVTIGRPLP
     NVQAYVLDEK LLPVPVGVTG ELYIGGAGLA RGYLNRPELT LERFIPHPFN EGERLYRTGD
     LVRYLADGHL DYLGRIDNQV KIRGFRIELG EIEANLESHP SVKEAVVLIR EDQPGDQRLV
     AYVVGEGSMH EWREHLKRQV PNHMIPAHFI EVDAIPLTTN GKVDRKALNS LTIQRENTFS
     TPIIPRDEIE YQLITIWQDL LQLEDIHVND DFFNIGGHSL LVIKLISKVR EKFGKEIKVP
     ALIKNPTVEG IACLIRENHR MEESLSVLVP LQESEKRPFF CVHPFMGNVL CYIQLARLLK
     DHCSFYGLQN PLVEKEGMNG LILSEVVQLY IEEMKRAQPE GPYRLGGWSL GGAIAYEIAT
     MLRNQGEEVE VLVLLDTKVP SERDYKTEDD MLSYILEHFI HIELVDQEEE LVHQQDMLVE
     QLIVEGVLPP DANLTNLKQL INAHRKCLNL MAEHDLTPYF GEVIYFSAEE GKELFTDWKP
     LLKGRVNMYS VPGSHEEIVA SPAVEKLAKY LLNELEGIKE TSLSLTEK
//
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