ID B0TA78_HELMI Unreviewed; 573 AA.
AC B0TA78;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN Name=acsA {ECO:0000313|EMBL:ABZ83615.1};
GN ORFNames=HM1_0951 {ECO:0000313|EMBL:ABZ83615.1};
OS Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Heliobacteriaceae;
OC Heliomicrobium.
OX NCBI_TaxID=498761 {ECO:0000313|EMBL:ABZ83615.1, ECO:0000313|Proteomes:UP000008550};
RN [1] {ECO:0000313|EMBL:ABZ83615.1, ECO:0000313|Proteomes:UP000008550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51547 / Ice1 {ECO:0000313|Proteomes:UP000008550};
RX PubMed=18441057; DOI=10.1128/JB.00299-08;
RA Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT of the Firmicutes containing the simplest photosynthetic apparatus.";
RL J. Bacteriol. 190:4687-4696(2008).
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DR EMBL; CP000930; ABZ83615.1; -; Genomic_DNA.
DR RefSeq; WP_012282143.1; NC_010337.2.
DR AlphaFoldDB; B0TA78; -.
DR STRING; 498761.HM1_0951; -.
DR KEGG; hmo:HM1_0951; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_59_10_9; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000008550; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008550}.
FT DOMAIN 59..419
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 472..550
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 573 AA; 65165 MW; 99B03A44C82BA02D CRC64;
MHTERIPVFP GNPNLKSYEE ARATFRWEDV EREFSWHTTG KVNIAYEAID RNVLEKGLGD
KVALYYSDPA RQEAITYRQM MEQSNRFANV LRKHGIGKGE RVFIFMPRSP ELYWSFLGII
KVGAIAGPLF EAFMEGAVRD RLADAEAVAI VTTPALRKRI PKEDLPHLKH IFMVGIPEGG
LGEGELDWHA EMAEASPETD IEWGDREDPM LLLYTSGSTG KPKGVLHVHN GMIQHYQTGK
WILDLRPDDI YWCTADPGWV TGISYGVWAP YLNGVTSVVR GGRFRPDDWY KTIQDYQVNV
WYSAPTAFRM LMSAGDDIVK QFDLSCLRHI LSVGEPLNPE VIRWGLKVFN RRIHDNWWMT
ETGGQIISNY PCMDIKPGSM GKPFPGIHAA IIDDKGNELP PLQMGNLAVK APWPSMMRKI
WKNEAKYNEY FKIEGWYISG DSAYMDEEGY FWFQGRIDDV INTSGERVGP FEVESKLVEH
PAVAEAGVIG KPDPLRGEII KAFIALREGY LWTEELKKEI IDFVKKGLAA HAAPREIEVR
DKLPKTRSGK IMRRVLKAWE LGLPTGDLST MED
//
