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Database: UniProt/TrEMBL
Entry: B0VCR1_ACIBY
LinkDB: B0VCR1_ACIBY
Original site: B0VCR1_ACIBY 
ID   B0VCR1_ACIBY            Unreviewed;       745 AA.
AC   B0VCR1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:CAM85925.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:CAM85925.1};
GN   Name=idh {ECO:0000313|EMBL:CAM85925.1};
GN   OrderedLocusNames=ABAYE0980 {ECO:0000313|EMBL:CAM85925.1};
OS   Acinetobacter baumannii (strain AYE).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter;
OC   Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=509173 {ECO:0000313|Proteomes:UP000002446};
RN   [1] {ECO:0000313|EMBL:CAM85925.1, ECO:0000313|Proteomes:UP000002446}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AYE {ECO:0000313|EMBL:CAM85925.1,
RC   ECO:0000313|Proteomes:UP000002446};
RX   PubMed=18350144; DOI=10.1371/journal.pone.0001805;
RA   Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S.,
RA   Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S.,
RA   Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M.,
RA   Raoult D., Medigue C., Weissenbach J., Cruveiller S.;
RT   "Comparative analysis of Acinetobacters: three genomes for three
RT   lifestyles.";
RL   PLoS ONE 3:E1805-E1805(2008).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CU459141; CAM85925.1; -; Genomic_DNA.
DR   RefSeq; WP_000896677.1; NC_010410.1.
DR   ProteinModelPortal; B0VCR1; -.
DR   EnsemblBacteria; CAM85925; CAM85925; ABAYE0980.
DR   KEGG; aby:ABAYE0980; -.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   Proteomes; UP000002446; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002446};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:CAM85925.1}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     550    550       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   745 AA;  82674 MW;  C78D1028949F2F92 CRC64;
     MAGEKSTIIY TLTDEAPLLA TYSLLPIIET FTKPAGIEIV KSDISVAARV LAEFADYLSE
     EQKVSDNLAE LGRLTQDPDT NIIKLPNISA SVAQLTACIK ELQSKGYAIP DYPENPATEE
     EKTIKARYGK CLGSAVNPVL REGNSDRRAP AAVKNYAKKH PHSMSEWKQW SQTHVSHMEE
     GDFYHGEKSM TLDRPRNVKM ELITNSGKSI VLKPKVALQE GEIIDSMFMS KKALCDFYEK
     QLDDCREAGI LFSLHVKATM MKVSHPIVFG HCVKIYYKEA FEKHGKLFDE LGINVNNGMA
     GLYEKIETLP TSLREEIIED LHACQEHRPA LAMVDSAKGI TNFHSPNDII VDASMPAMIR
     AGGKMWGADG KQYDAKAVMP ESTFARIYQE MINFCKWHGN FDPKTMGTVP NVGLMAQKAE
     EYGSHDKTFE IPEAGIANIT DFDTGEVLLT QNVEEGDIWR MCQVKDAPIR DWVKLAVTRA
     RNSGMPAIFW LDPYRPHENE LIKKVQKYLK DHDTTGLDIQ IMSQVRAMRY TLERVVRGLD
     TISVTGNILR DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN
     HLRWDSLGEF LALAVSLEEM GIKENNARAK LLAKTLDEAT GKLLDNDKSP SRRTGELDNR
     GSHFYLSLYW AEALAAQNED AELKAKFAPL AKALAENEQK IVAELAQVQG KPADIGGYYA
     VDPAKVSAVM RPSATFNAAL STVQA
//
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