ID B0WYU2_CULQU Unreviewed; 1091 AA.
AC B0WYU2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Vitellogenin convertase {ECO:0000313|EMBL:EDS37202.1, ECO:0000313|EnsemblMetazoa:CPIJ011701-PA};
GN Name=6045170 {ECO:0000313|EnsemblMetazoa:CPIJ011701-PA};
GN ORFNames=CpipJ_CPIJ011701 {ECO:0000313|EMBL:EDS37202.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37202.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37202.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ011701-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ011701-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; DS232199; EDS37202.1; -; Genomic_DNA.
DR RefSeq; XP_001862564.1; XM_001862529.1.
DR AlphaFoldDB; B0WYU2; -.
DR STRING; 7176.B0WYU2; -.
DR MEROPS; S08.048; -.
DR EnsemblMetazoa; CPIJ011701-RA; CPIJ011701-PA; CPIJ011701.
DR KEGG; cqu:CpipJ_CPIJ011701; -.
DR VEuPathDB; VectorBase:CPIJ011701; -.
DR VEuPathDB; VectorBase:CQUJHB002854; -.
DR eggNOG; KOG3525; Eukaryota.
DR HOGENOM; CLU_002976_0_0_1; -.
DR InParanoid; B0WYU2; -.
DR OMA; AIFHEHY; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 2.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF3; FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00261; FU; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 991..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..409
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 119306 MW; 1F73F7DE172AFC25 CRC64;
MHDPGASYDV NGNDGDPMPH YDLTDSNRHG TRCAGEVAAT ANNSKCAVGI AYGARVGGVR
MLDGDVTDVV EAKSLGLHSQ HIDIYSASWG PDDDGKTVDG PGDMATRAFI EGVRKGRGGK
GSIFIWASGN GGREHDNCNC DGYTNSIWTL SISSASQEGL VPWFSEMCSS TLATTYSSGN
TNEKQVITTD LHHSCTSSHT GTSASAPLAA GIAALVLEAN RNLTWRDLQH IVVRTAKPGN
LKDPSWAKNG VGRRVSHSFG YGLMDAAAMV RLARTWKTVP DQQICEINAP HLDKQIPPRT
KVTLQLLVEH CMGVNYLEHV QAKITLTSQR RGDIQIFLTS PSGTRVTLLT PRSHDLSRSG
FNQWPFMSVH TWGEAPHGVW LLEIHNEGRL LGYSSIRGWS LILYGTSIPP DPNDPPNTPR
VFSTPALPPA ALPPIIPASG SFGSSKNFYS SSALGKPNRK QQQQYGGATY TPTFGMTPAY
QSPQPVTPPR KNNKGKNKPN KSQSSKTTTA RPVSQTTLNV FLNSYGTGKK YEYNTGPRKN
QTPKPKPMQT INYGRSDKYH AATSNIPEKQ PIAIKAPKQV KQDNAPNSRK LPTTIGTSSS
TTNSVPSTAT GTTSGGTTSL TTQPPIFNER FSTTNARIPN RFQQYEKIQQ FYPELKPYSS
IRDDLDHRTT PNKPVAAPPP PKNTPSIVTT NGNGKPSRAN PKIFFPDTDI IDAIAPRKIS
SSLQQQPVQP AFYGRTQNSQ FVSSSGGKNG KAQITQWNLI FYGTETPAQP DDPTRVGKPG
FSDSNFGGEI EHNSLEFESG VSSDQWRNMQ QIGESHVDVQ RTASSDVTSL ACARYDRARC
LECGSASFFY NGHCYSSCPA STFPDTSTME QDEKQQHQQQ RPLPPGSVRR RRGNNLDNEP
QERDTQPQPG QQHQHFCIPC HATCLECSGP AANQCTECQP EFAFDGLRLC VTINRKQRPQ
ASSGTNKSSN QTAPTLNDPE SDDKRWLPAD YLIMITVVGV TLVVAFAGIY LLWRRCFRGV
LLATDHHQYD RVQTSDPAAS GSRGVPSYAE LVRDEIDDIL AESSSEDEED DEHHDGRESR
SFMPIIAPVE R
//
