ID B0X774_CULQU Unreviewed; 127 AA.
AC B0X774;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 06-MAR-2013, entry version 37.
DE RecName: Full=Histone H2B;
GN ORFNames=CpipJ_CPIJ015005;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC Culicidae; Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and
CC compact DNA into chromatin, limiting DNA accessibility to the
CC cellular machineries which require DNA as a template. Histones
CC thereby play a central role in transcription regulation, DNA
CC repair, DNA replication and chromosomal stability. DNA
CC accessibility is regulated via a complex set of post-translational
CC modifications of histones, also called histone code, and
CC nucleosome remodeling (By similarity).
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two
CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
CC heterotetramer and two H2A-H2B heterodimers. The octamer wraps
CC approximately 147 bp of DNA (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- SIMILARITY: Belongs to the histone H2B family.
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DR EMBL; DS232441; EDS41768.1; -; Genomic_DNA.
DR RefSeq; XP_001865496.1; XM_001865461.1.
DR UniGene; Cpi.11761; -.
DR ProteinModelPortal; B0X774; -.
DR SMR; B0X774; 7-127.
DR EnsemblMetazoa; CPIJ015005-RA; CPIJ015005-PA; CPIJ015005.
DR GeneID; 6048601; -.
DR KEGG; cqu:CpipJ_CPIJ015005; -.
DR VectorBase; CPIJ015005; Culex quinquefasciatus.
DR eggNOG; NOG289161; -.
DR HOGENOM; HOG000231213; -.
DR KO; K11252; -.
DR OMA; RRETYAV; -.
DR OrthoDB; EOG4WSTT6; -.
DR PhylomeDB; B0X774; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_core_D.
DR InterPro; IPR000558; Histone_H2B.
DR PANTHER; PTHR23428; PTHR23428; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00621; HISTONEH2B.
DR SMART; SM00427; H2B; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00357; HISTONE_H2B; 1.
PE 3: Inferred from homology;
KW Chromosome; Complete proteome; DNA-binding; Isopeptide bond;
KW Nucleosome core; Nucleus.
SQ SEQUENCE 127 AA; 13904 MW; 03DD1CB218C28B84 CRC64;
MAPPKSSGKA AKKSSGKASK NIVKGDKKAK KKTKRKESYA IYIYKVLKQV HPDTGISSKA
MSIMNSFVND IFERIAAEAS RLAQYNKRST ITSREIQTAV RLLLPGELAK HAVSEGTKAV
TKYTSSK
//
