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Database: UniProt/TrEMBL
Entry: B1LVU9_METRJ
LinkDB: B1LVU9_METRJ
Original site: B1LVU9_METRJ 
ID   B1LVU9_METRJ            Unreviewed;       254 AA.
AC   B1LVU9;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   19-FEB-2014, entry version 45.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.228;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=Mrad2831_3623;
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM
OS   2831).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + guanine(37) in tRNA
CC       = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase TrmD family.
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DR   EMBL; CP001001; ACB25599.1; -; Genomic_DNA.
DR   RefSeq; YP_001756282.1; NC_010505.1.
DR   ProteinModelPortal; B1LVU9; -.
DR   STRING; 426355.Mrad2831_3623; -.
DR   EnsemblBacteria; ACB25599; ACB25599; Mrad2831_3623.
DR   GeneID; 6139676; -.
DR   KEGG; mrd:Mrad2831_3623; -.
DR   PATRIC; 22575656; VBIMetRad70578_3703.
DR   eggNOG; COG0336; -.
DR   HOGENOM; HOG000016242; -.
DR   KO; K00554; -.
DR   OMA; CGRFEGI; -.
DR   OrthoDB; EOG6J48RZ; -.
DR   ProtClustDB; CLSK2330328; -.
DR   BioCyc; MRAD426355:GJB5-3666-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:GOC.
DR   Gene3D; 1.10.1270.20; -; 1.
DR   HAMAP; MF_00605; TrmD; 1.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   InterPro; IPR023148; tRNA_m1G_MeTrfase_C.
DR   InterPro; IPR016009; tRNA_MeTrfase.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   REGION      144    149       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     124    124       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   254 AA;  26970 MW;  F67B8BFB90768F02 CRC64;
     MTRADTPWRA TILTLYPEMF PGPLGLSLSG DALARGDWTL EARNIREHGL GRHRSVDDTP
     AGGGAGMVLR CDVLAAAIDA AAVDAATGAD DPRPRLLMSP RGRPLTQARV RDLAAGPGAL
     IVCGRFEGVD ERVIAGRGLE EVSIGDYVLS GGEIAALVVL DACVRLLPGV MGKMESGVEE
     SFEGGLLEYP HYTRPRDWEG RAIPDVLSSG NHAAIARWRR AEAERITAER RPDLRDGSVA
     GQAGSRSITG PSRS
//
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