ID B1LVU9_METRJ Unreviewed; 254 AA.
AC B1LVU9;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 01-MAY-2013, entry version 41.
DE RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE EC=2.1.1.228;
DE AltName: Full=M1G-methyltransferase;
DE AltName: Full=tRNA [GM37] methyltransferase;
GN Name=trmD; OrderedLocusNames=Mrad2831_3623;
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM
OS 2831).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T.,
RA Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC (By similarity).
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + guanine(37) in tRNA
CC = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the RNA methyltransferase TrmD family.
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DR EMBL; CP001001; ACB25599.1; -; Genomic_DNA.
DR RefSeq; YP_001756282.1; NC_010505.1.
DR ProteinModelPortal; B1LVU9; -.
DR STRING; 426355.Mrad2831_3623; -.
DR EnsemblBacteria; ACB25599; ACB25599; Mrad2831_3623.
DR GeneID; 6139676; -.
DR KEGG; mrd:Mrad2831_3623; -.
DR PATRIC; 22575656; VBIMetRad70578_3703.
DR eggNOG; COG0336; -.
DR HOGENOM; HOG000016242; -.
DR KO; K00554; -.
DR OMA; PRLLMSP; -.
DR ProtClustDB; CLSK2330328; -.
DR BioCyc; MRAD426355:GJB5-3666-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:EC.
DR Gene3D; 1.10.1270.20; -; 1.
DR HAMAP; MF_00605; TrmD; 1; -.
DR InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR InterPro; IPR023148; tRNA_m1G_MeTrfase_C.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PIRSF; PIRSF000386; tRNA_mtase; 1.
DR TIGRFAMs; TIGR00088; trmD; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Methyltransferase;
KW S-adenosyl-L-methionine; Transferase; tRNA processing.
FT REGION 144 149 S-adenosyl-L-methionine binding (By
FT similarity).
FT BINDING 124 124 S-adenosyl-L-methionine; via amide
FT nitrogen (By similarity).
SQ SEQUENCE 254 AA; 26970 MW; F67B8BFB90768F02 CRC64;
MTRADTPWRA TILTLYPEMF PGPLGLSLSG DALARGDWTL EARNIREHGL GRHRSVDDTP
AGGGAGMVLR CDVLAAAIDA AAVDAATGAD DPRPRLLMSP RGRPLTQARV RDLAAGPGAL
IVCGRFEGVD ERVIAGRGLE EVSIGDYVLS GGEIAALVVL DACVRLLPGV MGKMESGVEE
SFEGGLLEYP HYTRPRDWEG RAIPDVLSSG NHAAIARWRR AEAERITAER RPDLRDGSVA
GQAGSRSITG PSRS
//
