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Database: UniProt/TrEMBL
Entry: B1XTH7_POLNS
LinkDB: B1XTH7_POLNS
Original site: B1XTH7_POLNS 
ID   B1XTH7_POLNS            Unreviewed;       744 AA.
AC   B1XTH7;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 62.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ACB43654.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ACB43654.1};
GN   OrderedLocusNames=Pnec_0369 {ECO:0000313|EMBL:ACB43654.1};
OS   Polynucleobacter necessarius subsp. necessarius (strain STIR1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=452638 {ECO:0000313|EMBL:ACB43654.1, ECO:0000313|Proteomes:UP000006582};
RN   [1] {ECO:0000313|Proteomes:UP000006582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STIR1 {ECO:0000313|Proteomes:UP000006582};
RX   PubMed=24167248; DOI=10.1073/pnas.1316687110;
RA   Boscaro V., Felletti M., Vannini C., Ackerman M.S., Chain P.S.,
RA   Malfatti S., Vergez L.M., Shin M., Doak T.G., Lynch M., Petroni G.;
RT   "Polynucleobacter necessarius, a model for genome reduction in both
RT   free-living and symbiotic bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:18590-18595(2013).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP001010; ACB43654.1; -; Genomic_DNA.
DR   RefSeq; WP_012357421.1; NC_010531.1.
DR   ProteinModelPortal; B1XTH7; -.
DR   STRING; 452638.Pnec_0369; -.
DR   EnsemblBacteria; ACB43654; ACB43654; Pnec_0369.
DR   KEGG; pne:Pnec_0369; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; PNEC452638:GI4T-335-MONOMER; -.
DR   Proteomes; UP000006582; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006582};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ACB43654.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006582}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       554    554       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     549    549       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   744 AA;  82426 MW;  D3FF53A04A8CF092 CRC64;
     MASEKSKIIY TLTDEAPLLA TCAFLPIIRT FTAPAGVEIV KSDISVAARI LAEFNDCLTP
     EQQVLDNLGA LGKMTLLPDI NIIKLPNISA SVPQLLAAIK ELQSKGYKIP DFPEDPKTDE
     EKSIRTRYSK CLGSSVNPVL REGNSDRRAP PAVKRYARKN PHSMGEWSQA SRTHVSHMHG
     GDFYSSEKSM TMTKACDVKM DLVTKSGKTI VLKPKVSLLA GEIIDSMYMS KKALCEFYEK
     EIEDAYKTGM MLSLHVKATM MKVSHPIVFG HAVKIFYKDA FEKHAKLFEE LSVNVNNGMS
     SLYEKIKTLP ESKREEIIQD LHACYEHRPA LAMVDSAKGI TNLHSPSDVI VDASMPAMIC
     VGGKMWGADG RLHDTKAVIP ESTFARIYQE MINFCKTHGN FDPKTMGTVP NVGLMAQQAE
     EYGSHDKTFE IPEAGVARIV ADDGTVLLEQ NVEEGDIWRM CQVKDAPIRD WVKLAVNRAR
     LSNTPAVFWL DEYRPHEAEL IKKVNTYLKD YDLTGVDIQI MSQTRAMRYT LERVIRGKDT
     ISVTGNILRD YLTDLFPIME LGTSAKMLSI VPLMAGGGLF ETGAGGSAPK HVQQLVEENH
     LRWDSLGEFL ALAVSLEDIG DKTGNQKVKI LARTLDEATG KLLDNNKSPS PRTGELDNRG
     SQFYLAMYWA EALAAQTEDK ELQAHFAPLA KTLIENEKKI AEELKAVQGK PADIGGYFVA
     DPEKCKAVMR PSATFNAALK AARI
//
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