ID B1XUQ5_POLNS Unreviewed; 211 AA.
AC B1XUQ5;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Pnec_0883;
OS Polynucleobacter necessarius subsp. necessarius (strain STIR1).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Polynucleobacter.
OX NCBI_TaxID=452638;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=STIR1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Hahn M.,
RA Richardson P.;
RT "Complete sequence of Polynucleobacter necessarius STIR1.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP001010; ACB44082.1; -; Genomic_DNA.
DR RefSeq; YP_001797696.1; NC_010531.1.
DR ProteinModelPortal; B1XUQ5; -.
DR STRING; 452638.Pnec_0883; -.
DR EnsemblBacteria; ACB44082; ACB44082; Pnec_0883.
DR GeneID; 6184410; -.
DR KEGG; pne:Pnec_0883; -.
DR PATRIC; 22970822; VBIPolNec8289_1025.
DR eggNOG; COG0125; -.
DR HOGENOM; HOG000229078; -.
DR KO; K00943; -.
DR OMA; ITLEGPE; -.
DR ProtClustDB; CLSK2323786; -.
DR BioCyc; PNEC452638:GI4T-891-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 13 20 ATP (By similarity).
SQ SEQUENCE 211 AA; 23840 MW; F014E7F281B660F6 CRC64;
MTSHTGYFIS FEGIDGAGKS THIDAFRNLI QERYPNIEVV MTREPGGTVL GEQLRNLLLD
TPMNLETEAL LMFAARREHL SQVIKPALTA GKIIISDRFT DASFAYQGGG RGLSLAKLND
LERWVQGQPD GSILQPNLTI LFDLPGDIAE ARRSKVHTPD KFEKMDLSFF ERVRQEYLRR
AKDDPDRFHL VDATQTPEAI WNGLKLIQID L
//
