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Database: UniProt/TrEMBL
Entry: B1YTC8_BURA4
LinkDB: B1YTC8_BURA4
Original site: B1YTC8_BURA4 
ID   B1YTC8_BURA4            Unreviewed;       364 AA.
AC   B1YTC8;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   19-FEB-2014, entry version 46.
DE   RecName: Full=Dihydroorotase;
DE            Short=DHOase;
DE            EC=3.5.2.3;
GN   Name=pyrC; OrderedLocusNames=BamMC406_0596;
OS   Burkholderia ambifaria (strain MC40-6).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=398577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC40-6;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Ramette A., Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-
CC       aspartate.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the DHOase family. Type 1 subfamily.
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DR   EMBL; CP001025; ACB63093.1; -; Genomic_DNA.
DR   RefSeq; YP_001807309.1; NC_010551.1.
DR   ProteinModelPortal; B1YTC8; -.
DR   SMR; B1YTC8; 20-363.
DR   STRING; 398577.BamMC406_0596; -.
DR   EnsemblBacteria; ACB63093; ACB63093; BamMC406_0596.
DR   GeneID; 6178756; -.
DR   KEGG; bac:BamMC406_0596; -.
DR   PATRIC; 19030504; VBIBurAmb82852_0601.
DR   eggNOG; COG0418; -.
DR   HOGENOM; HOG000256259; -.
DR   KO; K01465; -.
DR   OMA; YAEAFEQ; -.
DR   OrthoDB; EOG6TFCMH; -.
DR   ProtClustDB; PRK05451; -.
DR   BioCyc; BAMB398577:GH38-617-MONOMER; -.
DR   UniPathway; UPA00070; UER00117.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00219; PyrC_type1; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR004721; DHOdimr.
DR   InterPro; IPR002195; Dihydroorotase_CS.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   PIRSF; PIRSF001237; DHOdimr; 1.
DR   TIGRFAMs; TIGR00856; pyrC_dimer; 1.
DR   PROSITE; PS00482; DIHYDROOROTASE_1; 1.
DR   PROSITE; PS00483; DIHYDROOROTASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis;
KW   Zinc.
FT   METAL        31     31       Zinc 1 (By similarity).
FT   METAL        33     33       Zinc 1 (By similarity).
FT   METAL       117    117       Zinc 1; via carbamate group (By
FT                                similarity).
FT   METAL       117    117       Zinc 2; via carbamate group (By
FT                                similarity).
FT   METAL       154    154       Zinc 2 (By similarity).
FT   METAL       192    192       Zinc 2 (By similarity).
FT   METAL       268    268       Zinc 1 (By similarity).
FT   MOD_RES     117    117       N6-carboxylysine (By similarity).
SQ   SEQUENCE   364 AA;  39685 MW;  EC4610ECCD74A4FA CRC64;
     MASPFLTTPP MTASNASSPA TLTLARPDDL HLHLRDGDML AAVLPHTARQ FARAIVMPNL
     KPPVTTTAHA QAYRERILAA LPAGMTFEPL MTLYLTDNTA PDEIRRARDS GFVHGVKLYP
     AGATTNSDHG VSDLAKCAKT LEVMQETGMP LLVHGEVTDP SVDMFDREKV FIDRVMTPLR
     RDFPGLKVVF EHITTKDAAD YVRDADAAPG LLGATITPQH MLYSRNALFV GGIRPHYYCL
     PVLKRETHRV ALVEAATSGN PRFFLGTDSA PHARGAKETA CGCAGCYTAL HALELYAEAF
     DQAGALDKLE NFASRFGADF YGLPHSTETV TLRRETWELP REVFAGDTPV VPLRAGEAIG
     WKFA
//
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