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Database: UniProt/TrEMBL
Entry: B2GKD0_KOCRD
LinkDB: B2GKD0_KOCRD
Original site: B2GKD0_KOCRD 
ID   B2GKD0_KOCRD            Unreviewed;       737 AA.
AC   B2GKD0;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   25-APR-2018, entry version 60.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:BAG29150.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:BAG29150.1};
GN   Name=icd {ECO:0000313|EMBL:BAG29150.1};
GN   OrderedLocusNames=KRH_08030 {ECO:0000313|EMBL:BAG29150.1};
OS   Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 /
OS   DC2201).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=378753 {ECO:0000313|EMBL:BAG29150.1, ECO:0000313|Proteomes:UP000008838};
RN   [1] {ECO:0000313|EMBL:BAG29150.1, ECO:0000313|Proteomes:UP000008838}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9341 / DSM 348 / NBRC 103217 / DC2201
RC   {ECO:0000313|Proteomes:UP000008838};
RX   PubMed=18408034; DOI=10.1128/JB.01853-07;
RA   Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S.,
RA   Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N.,
RA   Harayama S.;
RT   "Complete genome sequence of the soil actinomycete Kocuria
RT   rhizophila.";
RL   J. Bacteriol. 190:4139-4146(2008).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; AP009152; BAG29150.1; -; Genomic_DNA.
DR   RefSeq; WP_012397871.1; NC_010617.1.
DR   ProteinModelPortal; B2GKD0; -.
DR   STRING; 378753.KRH_08030; -.
DR   EnsemblBacteria; BAG29150; BAG29150; KRH_08030.
DR   GeneID; 35827819; -.
DR   KEGG; krh:KRH_08030; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; KRHI378753:G1G2M-799-MONOMER; -.
DR   Proteomes; UP000008838; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008838};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:BAG29150.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008838}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       345    345       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       543    543       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     542    542       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        252    252       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        415    415       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   737 AA;  80308 MW;  B84D289DDAE14FFF CRC64;
     MPKIIYTETD EAPMLATYSF KPMVEAFAST AGVEVETRDI SLAARILAQF PDRLTDAQRV
     PDTLGELGEL AKTPEANIVK LPNISASIPQ LKAAIKELQA DGYDLPDYPE DASSDEAKDV
     RARYDRVKGS AVNPVLREGN SDRRAPKAVK EYAKKHPHTM GAWSEDSRTN VATLGHDDFR
     TNEQSVVMPA DDTLTIQLVS DGKTTVLKQS VPVLAGEVVD ATFMSAAALD EFLTAQVVRA
     KEEGILFSAH LKATMMKVSD PIIFGHVVSA FFQDVMERYG ADLAKAGLSP NDGLAGILSG
     LDALENGAEI KAAFQEAIDN GPELAYVNSD KGITNLHVPS DVIVDASMPA MIRTSGQMWG
     REGEQKDTLA VLPDSSYAGV YQTVIDDCRE NGAYDPTTMG TVPNVGLMAQ KAEEYGSHDK
     TFEITEAGTV QVVNSAGNVL MSHDVQPGDI WRACQAKDAP IKDWVQLAVR RSRESGMPAV
     FWLDESRAHD RNLIEKVNTY LAQEDTDGLD LRILSPVEAT QFTIDRIRRG EDTISVTGNV
     LRDYLTDLFP ILELGTSAKM LSIVPLMNGG GLFETGAGGS APKHVQQLQA ENHLRWDSLG
     EFLALAASFE HLATRFDNPK AQVLADTLDR ATGTFLNENK SPSRKVNELD NRGSHFYLAM
     YWAEELARQT EDAELAQAFR EVASELRANE ETINAELLGV QGSPADLGGY YWPKPELVSG
     VMRPSATLNR IVDSLTA
//
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