GenomeNet

Database: UniProt/TrEMBL
Entry: B2RXP3_MOUSE
LinkDB: B2RXP3_MOUSE
Original site: B2RXP3_MOUSE 
ID   B2RXP3_MOUSE            Unreviewed;       697 AA.
AC   B2RXP3;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-SEP-2017, entry version 82.
DE   SubName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000313|Ensembl:ENSMUSP00000124696};
DE   SubName: Full=SET domain bifurcated protein 2 variant C {ECO:0000313|EMBL:ABY55485.1};
DE   SubName: Full=SET domain bifurcated protein 2 variant D {ECO:0000313|EMBL:ABY55486.1};
DE   SubName: Full=Setdb2 protein {ECO:0000313|EMBL:AAI57927.1};
GN   Name=Setdb2 {ECO:0000313|EMBL:AAI57927.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000124696, ECO:0000313|MGI:MGI:2685139};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI57927.1};
RN   [1] {ECO:0000313|EMBL:AAI57927.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI57927.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|EMBL:ABY55485.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:ABY55485.1};
RA   Flynn E.K., Symer D.E.;
RT   "Conserved transcription-mediated gene fusion at the Setdb2-Phf11
RT   locus.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000124696, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124696,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000124696}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124696};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00563921}.
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DR   EMBL; AC114007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC157926; AAI57927.1; -; mRNA.
DR   EMBL; BC172021; AAI72021.1; -; mRNA.
DR   EMBL; EU155096; ABY55485.1; -; mRNA.
DR   EMBL; EU155097; ABY55486.1; -; mRNA.
DR   RefSeq; NP_001307649.1; NM_001320720.1.
DR   RefSeq; NP_001307650.1; NM_001320721.1.
DR   UniGene; Mm.205022; -.
DR   Ensembl; ENSMUST00000161459; ENSMUSP00000124696; ENSMUSG00000071350.
DR   GeneID; 239122; -.
DR   KEGG; mmu:239122; -.
DR   UCSC; uc011zmt.1; mouse.
DR   CTD; 83852; -.
DR   MGI; MGI:2685139; Setdb2.
DR   eggNOG; KOG1141; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00780000121845; -.
DR   HOVERGEN; HBG106688; -.
DR   KO; K18494; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000071350; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046974; F:histone methyltransferase activity (H3-K9 specific); IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   InterPro; IPR016177; DNA-bd_dom.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00391; MBD; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54171; SSF54171; 1.
DR   PROSITE; PS50982; MBD; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Nucleus {ECO:0000256|SAAS:SAAS00508279};
KW   Proteomics identification {ECO:0000213|MaxQB:B2RXP3,
KW   ECO:0000213|PeptideAtlas:B2RXP3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN      145    217       MBD. {ECO:0000259|PROSITE:PS50982}.
FT   DOMAIN      278    351       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      354    672       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   697 AA;  78802 MW;  AE97A5BB47D2726F CRC64;
     MEEKNGDAKT FWMELQDDGK VDLMFEKTQN VLHSLKQKIK DGSATNGDYV QAMNLVNEAT
     LSNTQTLEKD HTPVTQSEQE NKSSAVPSAS CDNSCPKGCT IPSPGKKVFL PVKNKADNLV
     KKEAPLHISF HRHICSRTCL METPLSLKGE NPLQLPIRCH FQRRHAKTNS HSSALHVNYK
     TPCGRNLRNM EEVFHYLLET ECNFLFTDNF SFNTYVQLTR NHPKQNEVVS DVDISNGVES
     VSIPFCNEID NSKLPRFKYR NTVWPRIYHL NFSNMFSDSC DCSEGCIDIK KCACLQLTAK
     NAKACPLSSD GECAGYKYKR LQRLIPTGIY ECNLLCKCNK QMCQNRVIQH GVRVRLQVFK
     SEKKGWGVRC LDDIDKGTFV CIYSGRLLRR ATPEKTNIGE NGREQQHIVK NSFSKKRKLE
     VVCSDCDAHC DSPKAEDCPP KLSGDLKEPA VEMNHRNISR TQHHSVIRRT KSKTTVFHYS
     EKNMGFVCSD SAAPEDKNGF KPAQEHVNSE ARRAHEDLSS NPAGDSEDTQ LTESDVIDIT
     ASREDSAPAY RCKHATIVDR KDTKQVLEVP GKKSQEEEPA ASQSQQALCD EELPSERTKI
     PSASLMQLSK ESLFLLDASK EGNVGRFLNH SCCPNLWVQN VFVETHDRNF PLVAFFTNRY
     VKARTELTWD YGYEAGATPA KEILCQCGFN KCRKKLI
//
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