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Database: UniProt/TrEMBL
Entry: B2UN19_AKKM8
LinkDB: B2UN19_AKKM8
Original site: B2UN19_AKKM8 
ID   B2UN19_AKKM8            Unreviewed;       492 AA.
AC   B2UN19;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   SubName: Full=Alpha amylase catalytic region {ECO:0000313|EMBL:ACD05630.1};
GN   OrderedLocusNames=Amuc_1812 {ECO:0000313|EMBL:ACD05630.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835 / Muc).
OC   Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05630.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / Muc {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
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DR   EMBL; CP001071; ACD05630.1; -; Genomic_DNA.
DR   RefSeq; WP_012420844.1; NC_010655.1.
DR   ProteinModelPortal; B2UN19; -.
DR   STRING; 349741.Amuc_1812; -.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   EnsemblBacteria; ACD05630; ACD05630; Amuc_1812.
DR   KEGG; amu:Amuc_1812; -.
DR   eggNOG; ENOG4105E5K; Bacteria.
DR   eggNOG; COG0366; LUCA.
DR   HOGENOM; HOG000094847; -.
DR   KO; K01176; -.
DR   OMA; VLNHKMG; -.
DR   OrthoDB; POG091H0HQ3; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR013776; A-amylase_thermo.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR001021-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001031};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001021-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT   DOMAIN        4    388       Aamy. {ECO:0000259|SMART:SM00642}.
FT   ACT_SITE    232    232       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR001021-1}.
FT   ACT_SITE    262    262       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR001021-1}.
FT   METAL       103    103       Calcium 1. {ECO:0000256|PIRSR:
FT                                PIRSR001021-2}.
FT   METAL       195    195       Calcium 1. {ECO:0000256|PIRSR:
FT                                PIRSR001021-2}.
FT   METAL       203    203       Calcium 2. {ECO:0000256|PIRSR:
FT                                PIRSR001021-2}.
FT   METAL       236    236       Calcium 1; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR001021-2}.
SQ   SEQUENCE   492 AA;  56720 MW;  30475071F02C7B3E CRC64;
     MKNGIMMQYF EWNLPNDGQF WNKLKEDAPH LEEMGVTAVW IPPAYKGKEQ NDVGYGTYDL
     FDLGEFDQKN TVRTKYGTRQ ELQEAIKALH EHHVGVYLDA VMNHKAGADY TEKFMAKEVD
     QQNRDKEITD AYEIEGWTGF NFPGRGNKYS DFKWHWYHFT GTDYDARTEK TSIFKIMGDG
     KSWSEGVDEE NGNYDYLMFA NLDFNHPEVV KEMERWGIWV SRELDLDGMR LDAIKHINDE
     FIRKFLAAVR KERGADFYAV GEYWKQDLES LDDYLKEERY KVDLFDVPLH YNMYQASKQG
     RDYDLSKILD GTLVQNHPTL AVTFVDNHDS QWGSSLESAV EDWFKPSAYA LILLMKEGYP
     CIFYGDYYGV SGNPPMHRAI IDNLLEIRKN HAFGEQNYYF DHPNTIGFTR VGDEEHPHSG
     VAVLISNGED GDKVMNVGKQ HAGETWKEAT GNVEETVSID GEGNGRFLVH GGNVAVWIPE
     NALQDARKED GK
//
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