ID B2UN39_AKKM8 Unreviewed; 592 AA.
AC B2UN39;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 01-MAY-2013, entry version 37.
DE RecName: Full=L-fucose isomerase;
DE EC=5.3.1.25;
DE AltName: Full=6-deoxy-L-galactose isomerase;
DE AltName: Full=FucIase;
GN Name=fucI; OrderedLocusNames=Amuc_1832;
OS Akkermansia muciniphila (strain ATCC BAA-835).
OC Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC Verrucomicrobiaceae; Akkermansia.
OX NCBI_TaxID=349741;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Smidt H., Derrien M., Plugge C.M., Zoetendal E.G.,
RA de Vos W.M., Richardson P.;
RT "Complete sequence of Akkermansia muciniphila ATCC BAA-835.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC ketose L-fuculose (By similarity).
CC -!- CATALYTIC ACTIVITY: L-fucose = L-fuculose.
CC -!- COFACTOR: Manganese (By similarity).
CC -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the L-fucose isomerase family.
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DR EMBL; CP001071; ACD05650.1; -; Genomic_DNA.
DR RefSeq; YP_001878431.1; NC_010655.1.
DR ProteinModelPortal; B2UN39; -.
DR SMR; B2UN39; 2-591.
DR STRING; 349741.Amuc_1832; -.
DR EnsemblBacteria; ACD05650; ACD05650; Amuc_1832.
DR GeneID; 6275647; -.
DR KEGG; amu:Amuc_1832; -.
DR PATRIC; 20836716; VBIAkkMuc16855_2082.
DR eggNOG; COG2407; -.
DR HOGENOM; HOG000249674; -.
DR KO; K01818; -.
DR OMA; KIGIRPT; -.
DR ProtClustDB; PRK10991; -.
DR BioCyc; AMUC349741:GHZ7-1887-MONOMER; -.
DR UniPathway; UPA00563; UER00624.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008736; F:L-fucose isomerase activity; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0019317; P:fucose catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.14.10; -; 1.
DR Gene3D; 3.40.275.10; -; 1.
DR Gene3D; 3.40.50.1070; -; 1.
DR HAMAP; MF_01254; Fucose_iso; 1; -.
DR InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR InterPro; IPR015888; Fuc_isomerase_C.
DR InterPro; IPR012888; Fucose_iso_N1.
DR InterPro; IPR005763; Fucose_isomerase.
DR InterPro; IPR009015; Fucose_isomerase_N/cen.
DR InterPro; IPR012889; Fucose_isomerase_N2.
DR Pfam; PF02952; Fucose_iso_C; 1.
DR Pfam; PF07881; Fucose_iso_N1; 1.
DR Pfam; PF07882; Fucose_iso_N2; 1.
DR SUPFAM; SSF50443; Fuc_isomerase_C; 1.
DR SUPFAM; SSF53743; Fuc_isomerase_N; 1.
DR TIGRFAMs; TIGR01089; fucI; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW Fucose metabolism; Isomerase; Manganese; Metal-binding.
FT ACT_SITE 336 336 Proton acceptor (By similarity).
FT ACT_SITE 360 360 Proton acceptor (By similarity).
FT METAL 336 336 Manganese (By similarity).
FT METAL 360 360 Manganese (By similarity).
FT METAL 527 527 Manganese (By similarity).
SQ SEQUENCE 592 AA; 64696 MW; 2A693E6BF9C66336 CRC64;
MKTALPTIGI RPTIDGRRLG VRESLEDQTM NMAKAAAALI EANIRHASGE PVKCVIADTC
IGGPAEAAAC ADKFKANNVG VSLAVTPCWC YGSETFDMDP FTPKAIWGFN GTERPGAVYL
AAALAGLNQK GFPAFSIYGK DVQDATDTSI PEDVAEKILR FCRAGLAVAT LRGKGYLSIG
GCSMGIAGSI VDQSFWENYL GIRVQAVDMT EVRRRMDQKI YDEAEFDLAM QWADSVFKFA
EDKNRPDLKL DEAGRRKTFR ESVLMAMIFR DMMQGNPKLK KIDREEESLG YQAIAGGFQG
QRHWTDFYPN GDIAETLLNS TFDWNGPRAP LPFATENDSL NGACLLFGYL LTGQANVFAD
VRTYWSPEAV KRVTGYTLEG HAKDGIIHLI NSGSAALDGC MACTGKDGQP VMKKHWDVTP
DDAKTMMEQA VWCPANREYF RGGGYSVHYV TRGGAPVTMM RLNIVKGLGP VLIVAEGWSV
DLPAEVHKTL DERTDPGWPT TWFAPRLTGK GAFTDVYSVM ANMGANHGAF TYGHIGADIL
TLASMLRIPV YAHNIPDDQI YRPSAWGLHG TADPEGADFR ACANYGPLYG KY
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