GenomeNet

Database: UniProt/TrEMBL
Entry: B2UN39_AKKM8
LinkDB: B2UN39_AKKM8
Original site: B2UN39_AKKM8 
ID   B2UN39_AKKM8            Unreviewed;       592 AA.
AC   B2UN39;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   26-NOV-2014, entry version 47.
DE   RecName: Full=L-fucose isomerase {ECO:0000256|HAMAP-Rule:MF_01254, ECO:0000256|SAAS:SAAS00051554};
DE            Short=FucIase {ECO:0000256|HAMAP-Rule:MF_01254};
DE            EC=5.3.1.25 {ECO:0000256|HAMAP-Rule:MF_01254, ECO:0000256|SAAS:SAAS00051551};
DE   AltName: Full=6-deoxy-L-galactose isomerase {ECO:0000256|HAMAP-Rule:MF_01254};
GN   Name=fucI {ECO:0000256|HAMAP-Rule:MF_01254};
GN   OrderedLocusNames=Amuc_1832 {ECO:0000313|EMBL:ACD05650.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835).
OC   Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC   Verrucomicrobiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05650.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
CC   -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC       ketose L-fuculose. {ECO:0000256|HAMAP-Rule:MF_01254}.
CC   -!- CATALYTIC ACTIVITY: L-fucopyranose = L-fuculose.
CC       {ECO:0000256|HAMAP-Rule:MF_01254, ECO:0000256|SAAS:SAAS00051545}.
CC   -!- COFACTOR:
CC       Note=Manganese. {ECO:0000256|HAMAP-Rule:MF_01254,
CC       ECO:0000256|SAAS:SAAS00051547};
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC       lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC       {ECO:0000256|HAMAP-Rule:MF_01254, ECO:0000256|SAAS:SAAS00051543}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01254,
CC       ECO:0000256|SAAS:SAAS00051541}.
CC   -!- SIMILARITY: Belongs to the L-fucose isomerase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01254}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001071; ACD05650.1; -; Genomic_DNA.
DR   RefSeq; WP_012420864.1; NC_010655.1.
DR   RefSeq; YP_001878431.1; NC_010655.1.
DR   ProteinModelPortal; B2UN39; -.
DR   SMR; B2UN39; 2-591.
DR   STRING; 349741.Amuc_1832; -.
DR   EnsemblBacteria; ACD05650; ACD05650; Amuc_1832.
DR   GeneID; 6275647; -.
DR   KEGG; amu:Amuc_1832; -.
DR   PATRIC; 20836716; VBIAkkMuc16855_2082.
DR   eggNOG; COG2407; -.
DR   HOGENOM; HOG000249674; -.
DR   KO; K01818; -.
DR   OMA; KEGQDYR; -.
DR   OrthoDB; EOG6FJNCF; -.
DR   BioCyc; AMUC349741:GHZ7-1887-MONOMER; -.
DR   UniPathway; UPA00563; UER00624.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008736; F:L-fucose isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0042355; P:L-fucose catabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.20.14.10; -; 1.
DR   Gene3D; 3.40.275.10; -; 1.
DR   Gene3D; 3.40.50.1070; -; 1.
DR   HAMAP; MF_01254; Fucose_iso; 1.
DR   InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR   InterPro; IPR015888; Fuc_isomerase_C.
DR   InterPro; IPR012888; Fucose_iso_N1.
DR   InterPro; IPR005763; Fucose_isomerase.
DR   InterPro; IPR009015; Fucose_isomerase_N/cen.
DR   InterPro; IPR012889; Fucose_isomerase_N2.
DR   Pfam; PF02952; Fucose_iso_C; 1.
DR   Pfam; PF07881; Fucose_iso_N1; 1.
DR   Pfam; PF07882; Fucose_iso_N2; 1.
DR   SUPFAM; SSF50443; SSF50443; 1.
DR   SUPFAM; SSF53743; SSF53743; 1.
DR   TIGRFAMs; TIGR01089; fucI; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051556};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001031};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051569};
KW   Fucose metabolism {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051568};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051563};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051565};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01254,
KW   ECO:0000256|SAAS:SAAS00051533};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT   ACT_SITE    336    336       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01254}.
FT   ACT_SITE    360    360       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01254}.
FT   METAL       336    336       Manganese. {ECO:0000256|HAMAP-Rule:
FT                                MF_01254}.
FT   METAL       360    360       Manganese. {ECO:0000256|HAMAP-Rule:
FT                                MF_01254}.
FT   METAL       527    527       Manganese. {ECO:0000256|HAMAP-Rule:
FT                                MF_01254}.
SQ   SEQUENCE   592 AA;  64696 MW;  2A693E6BF9C66336 CRC64;
     MKTALPTIGI RPTIDGRRLG VRESLEDQTM NMAKAAAALI EANIRHASGE PVKCVIADTC
     IGGPAEAAAC ADKFKANNVG VSLAVTPCWC YGSETFDMDP FTPKAIWGFN GTERPGAVYL
     AAALAGLNQK GFPAFSIYGK DVQDATDTSI PEDVAEKILR FCRAGLAVAT LRGKGYLSIG
     GCSMGIAGSI VDQSFWENYL GIRVQAVDMT EVRRRMDQKI YDEAEFDLAM QWADSVFKFA
     EDKNRPDLKL DEAGRRKTFR ESVLMAMIFR DMMQGNPKLK KIDREEESLG YQAIAGGFQG
     QRHWTDFYPN GDIAETLLNS TFDWNGPRAP LPFATENDSL NGACLLFGYL LTGQANVFAD
     VRTYWSPEAV KRVTGYTLEG HAKDGIIHLI NSGSAALDGC MACTGKDGQP VMKKHWDVTP
     DDAKTMMEQA VWCPANREYF RGGGYSVHYV TRGGAPVTMM RLNIVKGLGP VLIVAEGWSV
     DLPAEVHKTL DERTDPGWPT TWFAPRLTGK GAFTDVYSVM ANMGANHGAF TYGHIGADIL
     TLASMLRIPV YAHNIPDDQI YRPSAWGLHG TADPEGADFR ACANYGPLYG KY
//
DBGET integrated database retrieval system