ID B2UPI5_AKKM8 Unreviewed; 419 AA.
AC B2UPI5;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN OrderedLocusNames=Amuc_0625 {ECO:0000313|EMBL:ACD04462.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD04462.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
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DR EMBL; CP001071; ACD04462.1; -; Genomic_DNA.
DR AlphaFoldDB; B2UPI5; -.
DR SMR; B2UPI5; -.
DR STRING; 349741.Amuc_0625; -.
DR CAZy; GH33; Glycoside Hydrolase Family 33.
DR PaxDb; 349741-Amuc_0625; -.
DR KEGG; amu:Amuc_0625; -.
DR eggNOG; COG4409; Bacteria.
DR HOGENOM; CLU_024620_1_0_0; -.
DR OMA; IRSYDAC; -.
DR BioCyc; AMUC349741:G1GBX-680-MONOMER; -.
DR Proteomes; UP000001031; Chromosome.
DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000313|EMBL:ACD04462.1};
KW Hydrolase {ECO:0000313|EMBL:ACD04462.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..419
FT /note="exo-alpha-sialidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002783731"
FT DOMAIN 76..378
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
SQ SEQUENCE 419 AA; 45589 MW; 6CF910299C76EABA CRC64;
MTWLLCGRGK WNKVKRMMNS VFKCLMSAVC AVALPAFGQE EKTGFPTDRA VTVFSAGEGN
PYASIRIPAL LSIGKGQLLA FAEGRYKNTD QGENDIIMSV SKNGGKTWSR PRAIAKAHGA
TFNNPCPVYD AKTRTVTVVF QRYPAGVKER QPNIPDGWDD EKCIRNFMIQ SRNGGSSWTK
PQEITKTTKR PSGVDIMASG PNAGTQLKSG AHKGRLVIPM NEGPFGKWVI SCIYSDDGGK
SWKLGQPTAN MKGMVNETSI AETDNGGVVM VARHWGAGNC RRIAWSQDGG ETWGQVEDAP
ELFCDSTQNS LMTYSLSDQP AYGGKSRILF SGPSAGRRIK GQVAMSYDNG KTWPVKKLLG
EGGFAYSSLA MVEPGIVGVL YEENQEHIKK LKFVPITMEW LTDGEDTGLA PGKKAPVLK
//