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Database: UniProt/TrEMBL
Entry: B2UPI5_AKKM8
LinkDB: B2UPI5_AKKM8
Original site: B2UPI5_AKKM8 
ID   B2UPI5_AKKM8            Unreviewed;       419 AA.
AC   B2UPI5;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Amuc_0625 {ECO:0000313|EMBL:ACD04462.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS   81048 / CCUG 64013 / CIP 107961 / Muc).
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD04462.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC   / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
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DR   EMBL; CP001071; ACD04462.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2UPI5; -.
DR   SMR; B2UPI5; -.
DR   STRING; 349741.Amuc_0625; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 349741-Amuc_0625; -.
DR   KEGG; amu:Amuc_0625; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_0; -.
DR   OMA; IRSYDAC; -.
DR   BioCyc; AMUC349741:G1GBX-680-MONOMER; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ACD04462.1};
KW   Hydrolase {ECO:0000313|EMBL:ACD04462.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           39..419
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002783731"
FT   DOMAIN          76..378
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   419 AA;  45589 MW;  6CF910299C76EABA CRC64;
     MTWLLCGRGK WNKVKRMMNS VFKCLMSAVC AVALPAFGQE EKTGFPTDRA VTVFSAGEGN
     PYASIRIPAL LSIGKGQLLA FAEGRYKNTD QGENDIIMSV SKNGGKTWSR PRAIAKAHGA
     TFNNPCPVYD AKTRTVTVVF QRYPAGVKER QPNIPDGWDD EKCIRNFMIQ SRNGGSSWTK
     PQEITKTTKR PSGVDIMASG PNAGTQLKSG AHKGRLVIPM NEGPFGKWVI SCIYSDDGGK
     SWKLGQPTAN MKGMVNETSI AETDNGGVVM VARHWGAGNC RRIAWSQDGG ETWGQVEDAP
     ELFCDSTQNS LMTYSLSDQP AYGGKSRILF SGPSAGRRIK GQVAMSYDNG KTWPVKKLLG
     EGGFAYSSLA MVEPGIVGVL YEENQEHIKK LKFVPITMEW LTDGEDTGLA PGKKAPVLK
//
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