ID   B3DPF4_BIFLD            Unreviewed;       340 AA.
AC   B3DPF4;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   01-MAY-2013, entry version 35.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase;
DE            EC=4.2.1.46;
GN   Name=rfbB; OrderedLocusNames=BLD_1568;
OS   Bifidobacterium longum (strain DJO10A).
OC   Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=205913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DJO10A;
RX   PubMed=18505588; DOI=10.1186/1471-2164-9-247;
RA   Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R.,
RA   Pavlova N.V., Polouchine N.N., Richardson P.M., Shakova V.V.,
RA   Slesarev A.I., Weimer B., O'Sullivan D.J.;
RT   "Comparative genomic analysis of the gut bacterium Bifidobacterium
RT   longum reveals loci susceptible to deletion during pure culture
RT   growth.";
RL   BMC Genomics 9:247-247(2008).
CC   -!- CATALYTIC ACTIVITY: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-
CC       alpha-D-glucose + H(2)O.
CC   -!- COFACTOR: NAD (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. dTDP-glucose
CC       dehydratase subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000605; ACD99013.1; -; Genomic_DNA.
DR   RefSeq; YP_001955511.1; NC_010816.1.
DR   ProteinModelPortal; B3DPF4; -.
DR   STRING; 205913.BLD_1568; -.
DR   EnsemblBacteria; ACD99013; ACD99013; BLD_1568.
DR   GeneID; 6363341; -.
DR   KEGG; blj:BLD_1568; -.
DR   PATRIC; 21116148; VBIBifLon134794_1588.
DR   eggNOG; COG1088; -.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; IELICEL; -.
DR   ProtClustDB; CLSK813891; -.
DR   BioCyc; BLON205913:GJB4-1621-MONOMER; -.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR10366:SF41; PTHR10366:SF41; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Lyase.
SQ   SEQUENCE   340 AA;  38544 MW;  097F469A3CE9E289 CRC64;
     MAEELFTPHN IIVTGGCGFI GSNFVHYVYN NHPDVHVTVL DALTYAGNLE NIRGILGDRV
     EFVHGNICDA ELLDKIVPGH DAIVHYAAES HNDNSIANPE PFLKTNVEGT FRLLEAARKY
     DVRYHHVSTD EVYGDLALDD PAKFTERTPY HPSSPYSSTK ASSDLLVRAW HRTFGIRATI
     SNCSNNYGPF QHVEKFIPRQ ITNVLEGLRP KLYGNGENVR DWIHTDDHST GVWTILTKGR
     LGETYLIGAN GERNNITVLR DILAVMGQDP DAFDWVKDRP GHDRRYAIDS TKLRTELGWK
     PTHTDFQKGL EQTIKWYTDN RAWWEPAKAA TEAKYKQQGQ
//