ID B3E8G1_GEOLS Unreviewed; 316 AA.
AC B3E8G1;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 01-MAY-2013, entry version 40.
DE RecName: Full=Ferrochelatase;
DE EC=4.99.1.1;
DE AltName: Full=Heme synthase;
DE AltName: Full=Protoheme ferro-lyase;
GN Name=hemH; OrderedLocusNames=Glov_2930;
OS Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=398767;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1151 / DSM 17278 / SZ;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L.,
RA Brettin T., Detter J.C., Han C., Tapia R., Kuske C.R., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sung Y.,
RA Fletcher K.E., Ritalahti K.M., Loeffler F.E., Richardson P.;
RT "Complete sequence of chromosome of Geobacter lovleyi SZ.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX
CC (By similarity).
CC -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC from protoporphyrin-IX: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR EMBL; CP001089; ACD96637.1; -; Genomic_DNA.
DR RefSeq; YP_001953157.1; NC_010814.1.
DR ProteinModelPortal; B3E8G1; -.
DR STRING; 398767.Glov_2930; -.
DR EnsemblBacteria; ACD96637; ACD96637; Glov_2930.
DR GeneID; 6369048; -.
DR KEGG; glo:Glov_2930; -.
DR PATRIC; 21997529; VBIGeoLov31523_2861.
DR eggNOG; COG0276; -.
DR HOGENOM; HOG000060727; -.
DR KO; K01772; -.
DR OMA; WNNSSEV; -.
DR ProtClustDB; CLSK790160; -.
DR BioCyc; GLOV398767:GH32-3055-MONOMER; -.
DR UniPathway; UPA00252; UER00325.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00323; Ferrochelatase; 1; -.
DR InterPro; IPR001015; Ferrochelatase.
DR InterPro; IPR019772; Ferrochelatase_AS.
DR PANTHER; PTHR11108; PTHR11108; 1.
DR Pfam; PF00762; Ferrochelatase; 1.
DR TIGRFAMs; TIGR00109; hemH; 1.
DR PROSITE; PS00534; FERROCHELATASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW Metal-binding; Porphyrin biosynthesis.
FT METAL 189 189 Iron (By similarity).
FT METAL 268 268 Iron (By similarity).
SQ SEQUENCE 316 AA; 35427 MW; 02E630EB3509AE3E CRC64;
MRDTAIILLQ MGGPDSLEAV RPFLLNLFSD REIIKIGPAW LQPLIARMIV RRRTPAVMEK
YREIGGRSPI QELTRAQADT LAAKLGIPCH VGMRYWHPFT AETLAQLRKT GTKKLVALSL
YPHYSRATSG SSFNDLTRCL ADLDSDLEVV RIPHFYDHPL YIDALTEKIE AGLASFPNRT
GVQLLFSAHS LPQSFIAEGD PYLEHIQATV RLVMERFEGV QHRLAFQSRA GPVKWLEPST
DDTLKELAAN GCKSLLMVPL SFVSDHIETL HEIDIEYAAE AHKIGISDFR RTESLNSSPA
FISCLAELVR QALKSH
//
