ID   B3LVE6_DROAN            Unreviewed;       384 AA.
AC   B3LVE6;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   03-APR-2013, entry version 29.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
GN   Name=GF17503; Synonyms=Dana\GF17503; ORFNames=Dana_GF17503;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; CH902617; EDV41474.1; -; Genomic_DNA.
DR   RefSeq; XP_001952891.1; XM_001952856.1.
DR   STRING; 7217.FBpp0120695; -.
DR   EnsemblMetazoa; FBtr0122203; FBpp0120695; FBgn0094521.
DR   GeneID; 6500287; -.
DR   KEGG; dan:Dana_GF17503; -.
DR   FlyBase; FBgn0094521; Dana\GF17503.
DR   eggNOG; COG0276; -.
DR   InParanoid; B3LVE6; -.
DR   KO; K01772; -.
DR   OrthoDB; EOG4WH726; -.
DR   UniPathway; UPA00252; UER00325.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:EC.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00323; Ferrochelatase; 1; -.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; PTHR11108; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Heme biosynthesis; Iron; Lyase;
KW   Porphyrin biosynthesis.
SQ   SEQUENCE   384 AA;  43791 MW;  50516BE041E5CA5D CRC64;
     MFHHNTKLCR LASNVAANVR RLSGQQPKTA ILMLNMGGPQ NTDQVHDYLL RIMTDRDMIQ
     LPVQSRLGPW IAQRRTPEVQ KKYKEIGGGS PILKWTELQG QLMCERLDKI SPETAPHKHY
     VGFRYVNPLT ENTLAEIEKD KPERVVLFSQ YPQYSCATSG SSFNSIFTHY KKNNTPSNIK
     WSIIDRWGTH PLLVKTFAQR IRDELAKFDE TKRNDVVILF TAHSLPLKAV NRGDAYPSEI
     GASVHMVMQE LGQTNPYSLA WQSKVGPLPW LAPATDDAIK GYVKQGQKNF ILVPIAFVNE
     HIETLHELDI EYCDELAKEV GVEEIRRAAA PNDHPLFINA LSDIVADHLK SQQSVNPKFL
     MRCPMCTNPK CRESKKWYQQ LCSQ
//