GenomeNet

Database: UniProt/TrEMBL
Entry: B3MKG0_DROAN
LinkDB: B3MKG0_DROAN
Original site: B3MKG0_DROAN 
ID   B3MKG0_DROAN            Unreviewed;       678 AA.
AC   B3MKG0;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   01-OCT-2014, entry version 40.
DE   RecName: Full=NADPH--cytochrome P450 reductase {ECO:0000256|PIRNR:PIRNR000208};
DE            EC=1.6.2.4 {ECO:0000256|PIRNR:PIRNR000208};
GN   Name=Dana\GF14516 {ECO:0000313|EMBL:EDV31513.1};
GN   ORFNames=Dana_GF14516 {ECO:0000313|EMBL:EDV31513.1}, GF14516
GN   {ECO:0000313|FlyBase:FBgn0091543};
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217 {ECO:0000313|Proteomes:UP000007801};
RN   [1] {ECO:0000313|EMBL:EDV31513.1, ECO:0000313|Proteomes:UP000007801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: This enzyme is required for electron transfer from NADP
CC       to cytochrome P450. {ECO:0000256|PIRNR:PIRNR000208}.
CC   -!- CATALYTIC ACTIVITY: NADPH + n oxidized hemoprotein = NADP(+) + n
CC       reduced hemoprotein. {ECO:0000256|PIRNR:PIRNR000208}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR000208}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
CC       pyridine nucleotide cytochrome reductase family.
CC       {ECO:0000256|PIRNR:PIRNR000208}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CH902620; EDV31513.1; -; Genomic_DNA.
DR   RefSeq; XP_001962292.1; XM_001962256.1.
DR   STRING; 7217.FBpp0117708; -.
DR   EnsemblMetazoa; FBtr0119216; FBpp0117708; FBgn0091543.
DR   GeneID; 6497339; -.
DR   KEGG; dan:Dana_GF14516; -.
DR   FlyBase; FBgn0091543; Dana\GF14516.
DR   eggNOG; COG0369; -.
DR   InParanoid; B3MKG0; -.
DR   KO; K00327; -.
DR   OrthoDB; EOG7HQN7J; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.990.10; -; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR003097; FAD-binding_1.
DR   InterPro; IPR017927; Fd_Rdtase_FAD-bd.
DR   InterPro; IPR001094; Flavdoxin.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR029039; Flavoprotein-like.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR023208; P450R.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PIRSF; PIRSF000208; P450R; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007801};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR000208};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000208};
KW   NADP {ECO:0000256|PIRNR:PIRNR000208};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000208};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007801}.
SQ   SEQUENCE   678 AA;  76417 MW;  1BA5DCABCA3C8CFF CRC64;
     MASEQIIEEA AEAVAGGNEP FLGLLDIALL AVLIGGAAFY FLRSRKKEEE PVRSYSIQPT
     TVSTTTATDN SFIKKLKASG RSLVVFYGSQ TGTGEEFAGR LAKEGIRYRL KGMVADPEEC
     DMEELLQLKD IDNSLAVFCL ATYGEGDPTD NAMEFYEWIT NGDVDLTGLN YAVFGLGNKT
     YEHYNKVAIY VDKRLEELGA NRVFELGLGD DDANIEDDFI TWKDRFWPAV CDHFGIEGGG
     EEVLIRQYRL LEQPDVQPDR IYTGEIARLH SVQNQRPPFD AKNPFLAPIK VNRELHKGGG
     RSCMHIELSI EGSKMRYDAG DHVAMYPIND KGLVEKLGQL CNADLDTIFS LINTDTDSSK
     KHPFPCPTTY RTALTHYLEI TAIPRTHILK ELAEYCTDEK EKELLRSMAS ISPEGKEKYQ
     SWIQDACRNI VHILEDIKSC RPPIDHVCEL LPRLQPRYYS ISSSGKLHPT DVHVTAVLVE
     YKTPTGRVNK GVATTYLKNK QPKDGEEVKV PVFIRKSQFR LPTKPETPII MVGPGTGLAP
     FRGFIQERQH LRDEGKTVGE SILYFGCRKR SEDYIYESEL EEWVKKGTLN LKAAFSRDQA
     SKVYVQHLLE QDADLIWNVI GENKGHFYIC GDAKNMAVDV RNILVKILST KGNMSEADAV
     QYIKKMEAQK RYSADVWS
//
DBGET integrated database retrieval system