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Database: UniProt/TrEMBL
Entry: B3NQX4_DROER
LinkDB: B3NQX4_DROER
Original site: B3NQX4_DROER 
ID   B3NQX4_DROER            Unreviewed;       584 AA.
AC   B3NQX4;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   05-JUL-2017, entry version 73.
DE   SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDV57057.1};
DE            EC=3.4.24.- {ECO:0000313|EMBL:EDV57057.1};
GN   Name=Dere\GG19900 {ECO:0000313|EMBL:EDV57057.1};
GN   ORFNames=Dere_GG19900 {ECO:0000313|EMBL:EDV57057.1}, GG19900
GN   {ECO:0000313|FlyBase:FBgn0112100};
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220 {ECO:0000313|EMBL:EDV57057.1, ECO:0000313|Proteomes:UP000008711};
RN   [1] {ECO:0000313|EMBL:EDV57057.1, ECO:0000313|Proteomes:UP000008711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000313|Proteomes:UP000008711};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00734478};
CC   -!- SIMILARITY: Belongs to the peptidase M10A family.
CC       {ECO:0000256|SAAS:SAAS00542437}.
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DR   EMBL; CH954179; EDV57057.1; -; Genomic_DNA.
DR   RefSeq; XP_001976657.1; XM_001976621.2.
DR   ProteinModelPortal; B3NQX4; -.
DR   MEROPS; M10.031; -.
DR   EnsemblMetazoa; FBtr0139954; FBpp0138446; FBgn0112100.
DR   GeneID; 6548508; -.
DR   KEGG; der:Dere_GG19900; -.
DR   FlyBase; FBgn0112100; Dere\GG19900.
DR   KO; K07763; -.
DR   OMA; ITTILMC; -.
DR   OrthoDB; EOG091G03DP; -.
DR   PhylomeDB; B3NQX4; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007505; P:adult fat body development; IEA:EnsemblMetazoa.
DR   GO; GO:0034769; P:basement membrane disassembly; IEA:EnsemblMetazoa.
DR   GO; GO:0007155; P:cell adhesion; IEA:EnsemblMetazoa.
DR   GO; GO:0045216; P:cell-cell junction organization; IEA:EnsemblMetazoa.
DR   GO; GO:0035001; P:dorsal trunk growth, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0097156; P:fasciculation of motor neuron axon; IEA:EnsemblMetazoa.
DR   GO; GO:0007561; P:imaginal disc eversion; IEA:EnsemblMetazoa.
DR   GO; GO:0002168; P:instar larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0007591; P:molting cycle, chitin-based cuticle; IEA:EnsemblMetazoa.
DR   GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0035071; P:salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0042246; P:tissue regeneration; IEA:EnsemblMetazoa.
DR   GO; GO:0007419; P:ventral cord development; IEA:EnsemblMetazoa.
DR   CDD; cd00094; HX; 1.
DR   CDD; cd04278; ZnMc_MMP; 1.
DR   Gene3D; 2.110.10.10; -; 2.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR000585; Hemopexin-like_dom.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR018486; Hemopexin_CS.
DR   InterPro; IPR033739; M10A_MMP.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   Pfam; PF00045; Hemopexin; 4.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SMART; SM00120; HX; 4.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   PROSITE; PS00024; HEMOPEXIN; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|SAAS:SAAS00710469};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008711};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00734812};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00458299,
KW   ECO:0000313|EMBL:EDV57057.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00082048};
KW   Metalloprotease {ECO:0000256|SAAS:SAAS00473618};
KW   Protease {ECO:0000256|SAAS:SAAS00082023};
KW   Repeat {ECO:0000256|SAAS:SAAS00710432};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|SAAS:SAAS00082033}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    584       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002792874.
FT   DOMAIN      112    269       ZnMc. {ECO:0000259|SMART:SM00235}.
SQ   SEQUENCE   584 AA;  64578 MW;  AC3A053C504DFA68 CRC64;
     MTNCQSSAFI VVGTVLSILV AAQSAPVSTT TQAEIYLSQF GYLPASARNP ASSGLHDQQT
     WVSAIEEFQN FAGLNITGEL DAETMKLMSL PRCGVRDRVG TGDSRSKRYA LQGSRWRVKN
     LTYKISKYPK RLKRVDVDAE IGRAFAVWSE DTDLTFTRKT SGPVHIEIKF VESEHGDGDA
     FDGQGGTLAH AFFPVFGGDA HFDDAEQWTI GSHRGTNLFQ VAAHEFGHSL GLSHSDQSAA
     LMAPFYRGFE PSFKLDDDDK AAIQSLYGKK SYPLRPTNVY PATTQRPYTP PKVPLDDSIC
     KDSKVDTLFN SAQGETYAFK GDKYYKLTTD SVEEGYPQLI SKGWPGLPAN IDAAFTYKNG
     KTYFFKGTQY WRYQGRQMDG VYPKEISEGF TGIPDHLDAA MVWGGNGKIY FFKGSKFWRF
     DPAKRPPVKS SYPKPISNWE GVPNNLDAAL KYTNGYTYFF KGDKYYRFHD ARFAVDSATP
     PFPRPTAHWW FGCKNTPSST GNIVEGSDNE FEQHSMIPHA DDGNGDDFDA AVGDHQSNDE
     PIAPEVAERT GNGAMSQSKL TSSSAVGTVI TTILMCLVSK LIVS
//
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