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Database: UniProt/TrEMBL
Entry: B3NTM2_DROER
LinkDB: B3NTM2_DROER
Original site: B3NTM2_DROER 
ID   B3NTM2_DROER            Unreviewed;      1181 AA.
AC   B3NTM2;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   30-AUG-2017, entry version 52.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00818223};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00818223};
GN   Name=Dere\GG17876 {ECO:0000313|EMBL:EDV47026.2};
GN   ORFNames=Dere_GG17876 {ECO:0000313|EMBL:EDV47026.2}, GG17876
GN   {ECO:0000313|FlyBase:FBgn0110096};
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220 {ECO:0000313|EMBL:EDV47026.2, ECO:0000313|Proteomes:UP000008711};
RN   [1] {ECO:0000313|EMBL:EDV47026.2, ECO:0000313|Proteomes:UP000008711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000313|Proteomes:UP000008711};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00818219}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00818221}.
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DR   EMBL; CH954180; EDV47026.2; -; Genomic_DNA.
DR   RefSeq; XP_001978099.2; XM_001978063.2.
DR   EnsemblMetazoa; FBtr0137930; FBpp0136422; FBgn0110096.
DR   GeneID; 6550717; -.
DR   KEGG; der:Dere_GG17876; -.
DR   FlyBase; FBgn0110096; Dere\GG17876.
DR   KO; K11407; -.
DR   OrthoDB; EOG091G0210; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:EnsemblMetazoa.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0022904; P:respiratory electron transport chain; IEA:EnsemblMetazoa.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:EnsemblMetazoa.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.800.20; -; 2.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00818226};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008711};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00490343};
KW   Nucleus {ECO:0000256|SAAS:SAAS00818233};
KW   Transcription {ECO:0000256|SAAS:SAAS00818215};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00818213}.
FT   DOMAIN     1006   1067       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   ZN_FING    1006   1067       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
SQ   SEQUENCE   1181 AA;  130565 MW;  8B517B8F70D226D2 CRC64;
     MSPPIVTRRS AQQAKIQTRA MASKSKAGTA VAATAAGVIS AGSSGGGSGG FNAADPRKTN
     KPNAALLEAK RRARNNMLKN QGSGSHECVT DIFQNAVNCK GLVRKPTALI YDESMSHHCC
     LWDKEHYECP ERFTRVLERC RELNLPERCL ELPSRSATKD EILRLHTEEH FERLKETSGI
     RDDERMEELS SRYDSIYIHP STFELSLLAS GSTIELVDHL VAGKAQNGMA IIRPPGHHAM
     KAEYNGYCFF NNVALAAQHA LDVHKLQRIL IIDYDVHHGQ GTQRFFYNDP RVVYFSIHRF
     EHGSFWPHLQ ESDYHAIGAG AGTGYNFNVP LNALGMTNGD YLAIFQQLLL PVALEFQPEL
     IIVSAGYDAA LGCPEGEMEV TPACYPHLLN PLLRLADARV AVVLEGGYCL DSLAEGAALT
     LRSLLGDPCP PLVEPVPLPR AELAQALLSC IAVHRPHWRC LQLQQTYDCE ELQDRDKGQD
     LHKVLRQWIG GPPPMDRYPT RDTAIPLPAE QVARNAARLQ VLRTETKLSV PSVRVCYAYD
     AQMLLHCNLN DTGHPEQPTR IQQIHKMHGE YALLPRMKQL SARAATTDEV CLAHTRAHVN
     TVRRLLGREP EDLHGAAAIY NSVYLHPRTF DCATLAAGSV LQAVDSVLRG ESRSGICNVR
     PPGHHAEQDQ PHGFCIFNNV AIAAQYAIRD FGLERVLIVD WDVHHGNGTQ HIFESNPKVL
     YMSLHRYEHG AFFPKGPDGN FDVVGKGAGR GFNVNIPWNK KGMGDLEYAL AFQQLVMPIA
     YEFNPQLVLV SAGFDAAIGD PLGGCKVTPE GYGMLTHWLS ALASGRIIVC LEGGYNVNSI
     SYAMTMCTKT LLGDYVPTPQ LGAAALQKPA TVAYQSCVES LQQCLQVQRN HWRSLEFVGR
     RLPSYPVVGE NNNEDFLTAS LRHLNISSDD APGAAGGPAG DQPDCGDERP SGSKPKVKVK
     TLTDYLAENK EALEQSEMFA VYPLKTCPHL RLLRPEEAPQ SLDSGAACSV CGSTGENWVC
     LGCRLVACGR YMNAHMEQHS VEAQHPLAMS TADLSVWCYA CSAYVDHPRL YAYLNALHVH
     KFQEPMAWTH GCAWREDGCY AVGPNGRDED ADQDDAVAGS SICLRLERHN XPLAIRVLDA
     LTDYMCALCP PLRHLIQFLA EHVWPLLERI YLNLLHYFLA H
//
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