ID   B4HIS0_DROSE            Unreviewed;       968 AA.
AC   B4HIS0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   06-MAR-2013, entry version 30.
DE   SubName: Full=GM23891;
GN   Name=GM23891; Synonyms=Dsec\GM23891; ORFNames=Dsec_GM23891;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH480815; EDW42717.1; -; Genomic_DNA.
DR   RefSeq; XP_002031731.1; XM_002031695.1.
DR   EnsemblMetazoa; FBtr0206876; FBpp0205368; FBgn0178756.
DR   GeneID; 6606937; -.
DR   KEGG; dse:Dsec_GM23891; -.
DR   FlyBase; FBgn0178756; Dsec\GM23891.
DR   KO; K00288; -.
DR   OrthoDB; EOG4WH71P; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; -; 1.
DR   HAMAP; MF_01543; FTHFS; 1; -.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1; -.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Pfam; PF01268; FTHFS; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
DR   PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome.
SQ   SEQUENCE   968 AA;  103408 MW;  E7883FDD99B92874 CRC64;
     MSAQYQRFLK VLEKWPAEKS KVGSGEWTAE PAIKMSGAKI ISGTAVAKSI REELRNEVTA
     MGKQLADFVP GLRIVQVGGR EDSNVYIRMK IKAATEIGID AAHVQLPRSI TEVELLDKIN
     DLNEDPRVHG IIVQMPLDCD TTIDSHRITD AVSPEKDVDG LHTVNEGRLA IGDLGGFLPC
     TPWGCLELIR RSGVEIAGAR AVVLGRSKIV GTPAAELLKW ANATVTVCHS KTRNLEEITR
     SADILVVGIG VAEMVKGSWI KPGAVVIDCG INVKPDASKA SGSKLVGDVD YAEALQVAGH
     LTPVPGGVGP MTVAMLMKNT VRSAARFLER LARSQWALQT LPLKPQRPVP SDIVIARAQK
     PKDIAVLAKE IGLEAREVSL YGNKKAKISL SVLERLKDKE AGHYVVVAGM TPTPLGEGKT
     TTLMGLVQAL GAHKLRNTMA ALRQPSQGPT FGIKGGAAGG GYAQVIPMEE FNLHLTGDIH
     AVSAANNLLA AQLDTRIFHE NTQKDKALYD RLVPAIKGQR KFSPIQLRRL QKLGITKTDP
     DTLTAEEYGP FARLDIDPDT IMWERVVDIN DRYLRTITVG QSPTEKGISR ETRFSISVAS
     EIMAVLALSR SLEDMKQRLA DMVVAFDKRG KPVTADDLGV TGALAVLLKD ALEPNLMQSL
     EGTPVLVHAG PFANIAHGCN SIIADEVGLK LVGKDGFVCT EAGFGSDIGM EKFCNIKCRT
     SGRKPNAMVL VATVRAIKMH GGGAPVTPGA PLNKQYTEEN LELVQKGLPN LLQHIENGKA
     FGMPVVVSLN AHSADTPAEH ELVKKAALEA GAFAAVVSTH WADGGAGAVE LAGAVIKACE
     QGNQFRLLYD LDLPLVDKMN KIATTMYGAG KVVLSPAAEE KVKRLTDAGF GNLPICMSKV
     SGSFTGDAKV KGAPKGFTLD VEDVYVSAGA GFVVAMCGEV TKMPGLPTRP AIYDIDLNTE
     TGEIEGLF
//