GenomeNet

Database: UniProt/TrEMBL
Entry: B4HTK4_DROSE
LinkDB: B4HTK4_DROSE
Original site: B4HTK4_DROSE 
ID   B4HTK4_DROSE            Unreviewed;       826 AA.
AC   B4HTK4;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   11-JUN-2014, entry version 43.
DE   RecName: Full=Ubiquitin carboxyl-terminal hydrolase;
DE            EC=3.4.19.12;
GN   Name=Dsec\GM14081; ORFNames=Dsec_GM14081, GM14081;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester,
CC       thioester, amide, peptide and isopeptide bonds formed by the C-
CC       terminal Gly of ubiquitin (a 76-residue protein attached to
CC       proteins as an intracellular targeting signal).
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC   -!- SIMILARITY: Contains USP domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CH480817; EDW50275.1; -; Genomic_DNA.
DR   RefSeq; XP_002035139.1; XM_002035103.1.
DR   ProteinModelPortal; B4HTK4; -.
DR   EnsemblMetazoa; FBtr0197066; FBpp0195558; FBgn0169010.
DR   GeneID; 6610566; -.
DR   KEGG; dse:Dsec_GM14081; -.
DR   FlyBase; FBgn0169010; Dsec\GM14081.
DR   KO; K11836; -.
DR   OrthoDB; EOG7CNZF3; -.
DR   PhylomeDB; B4HTK4; -.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008242; F:omega peptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR018200; Pept_C19ubi-hydrolase_C_CS.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR009060; UBA-like.
DR   InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR   InterPro; IPR000449; UBA/Ts_N.
DR   InterPro; IPR016652; Ubiquitinyl_hydrolase.
DR   InterPro; IPR028889; UCH/PAN2.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF00627; UBA; 2.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PIRSF; PIRSF016308; UBP; 1.
DR   SMART; SM00165; UBA; 2.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS50030; UBA; 2.
DR   PROSITE; PS00972; UCH_2_1; 1.
DR   PROSITE; PS00973; UCH_2_2; 1.
DR   PROSITE; PS50235; UCH_2_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Protease; Thiol protease;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   ACT_SITE    340    340       Nucleophile (By similarity){EA3}.
FT   ACT_SITE    787    787       Proton acceptor (By similarity){EA3}.
SQ   SEQUENCE   826 AA;  92078 MW;  2375A15632FC0B69 CRC64;
     MEELRKHLSK VNVPCVSGAG SPPIYKDECV YSYDNPETPT GLYVCLHSFL GFGEAYVREY
     ANKTGNRIFL HIQRVKTIKE GADMDADAES EAGPERKITR LAIGVEGGYN ESDMAKKYEI
     KDTYSIVVAP DLDKKLPYPD PELPMRVTQS VEAILAADSA IAKLEKATLM GTWDGEVRQA
     SKYAENLQQL DNGKRIPPSG WQCEKCDLTN NLWLNLTDGS IMCGRKFFDG SGGNDHAVEH
     YRVTGFPLAV KLGTITADGK SDVFSYPEDE MVLDPHLERH LSHFGINMAA MKKSEKSMVE
     LELDINHRIG EWSALTESES ELQPVAGPGY TGMRNLGNSC YINSVMQVLF IIPDFQQRFV
     GTGAERYFSE FPSDPANDFN IQMAKLGTGL QSGKYSSIAE NTLDTDHITG ISPAMFKNIV
     GKNHPDFSTK QQQDANDFYL HLLTLLDRNS RNQTNPADAL KFLLEDRVEC LASRKVKYRT
     REEYSFRLPV PLDKATNLDE VREFQERKKA ARETGQRLPD RDIVRHKVPL QACLERFFAP
     ELIEQFYSTA IDGKTNARKI TRLATMPDCL MIHVGKFTLG DDWVPKKLDV SVDMPDELDL
     SNWRSAGGLQ PGEEALPEPA AEEVKFAFDE AVMSELLTMG FPPEACKRAC YHTKNSGLEA
     ASNWLMEHIA DEDISEPFVV PNNSIGDCAA NQFVANPESL AMLMSMGFDE RQAVAALKAT
     DGNVERATDW IFSHADSISV EEAAPASNSS AAAASSAPNK TDYRDGRGKY RLVGFISHMG
     TSAQVGHYVC HIRKKGEWVI FNDSKVAKSQ NPPKDLGYLY LYMREQ
//
DBGET integrated database retrieval system