ID B4HTK4_DROSE Unreviewed; 826 AA.
AC B4HTK4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 03-APR-2013, entry version 33.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase;
DE EC=3.4.19.12;
GN Name=GM14081; Synonyms=Dsec\GM14081; ORFNames=Dsec_GM14081;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester,
CC thioester, amide, peptide and isopeptide bonds formed by the C-
CC terminal Gly of ubiquitin (a 76-residue protein attached to
CC proteins as an intracellular targeting signal).
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
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DR EMBL; CH480817; EDW50275.1; -; Genomic_DNA.
DR RefSeq; XP_002035139.1; XM_002035103.1.
DR ProteinModelPortal; B4HTK4; -.
DR EnsemblMetazoa; FBtr0197066; FBpp0195558; FBgn0169010.
DR GeneID; 6610566; -.
DR KEGG; dse:Dsec_GM14081; -.
DR FlyBase; FBgn0169010; Dsec\GM14081.
DR KO; K11836; -.
DR OrthoDB; EOG4NGF2M; -.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008242; F:omega peptidase activity; IEA:InterPro.
DR GO; GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR018200; Pept_C19ubi-hydrolase_C_CS.
DR InterPro; IPR001394; Peptidase_C19.
DR InterPro; IPR009060; UBA-like.
DR InterPro; IPR000449; UBA/transl_elong_EF1B_N.
DR InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR InterPro; IPR016652; Ubiquitinyl_hydrolase.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR Pfam; PF00627; UBA; 2.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR PIRSF; PIRSF016308; UBP; 1.
DR SMART; SM00165; UBA; 2.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF46934; UBA_like; 1.
DR PROSITE; PS50030; UBA; 2.
DR PROSITE; PS00972; UCH_2_1; 1.
DR PROSITE; PS00973; UCH_2_2; 1.
DR PROSITE; PS50235; UCH_2_3; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Metal-binding; Protease; Thiol protease;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
SQ SEQUENCE 826 AA; 92078 MW; 2375A15632FC0B69 CRC64;
MEELRKHLSK VNVPCVSGAG SPPIYKDECV YSYDNPETPT GLYVCLHSFL GFGEAYVREY
ANKTGNRIFL HIQRVKTIKE GADMDADAES EAGPERKITR LAIGVEGGYN ESDMAKKYEI
KDTYSIVVAP DLDKKLPYPD PELPMRVTQS VEAILAADSA IAKLEKATLM GTWDGEVRQA
SKYAENLQQL DNGKRIPPSG WQCEKCDLTN NLWLNLTDGS IMCGRKFFDG SGGNDHAVEH
YRVTGFPLAV KLGTITADGK SDVFSYPEDE MVLDPHLERH LSHFGINMAA MKKSEKSMVE
LELDINHRIG EWSALTESES ELQPVAGPGY TGMRNLGNSC YINSVMQVLF IIPDFQQRFV
GTGAERYFSE FPSDPANDFN IQMAKLGTGL QSGKYSSIAE NTLDTDHITG ISPAMFKNIV
GKNHPDFSTK QQQDANDFYL HLLTLLDRNS RNQTNPADAL KFLLEDRVEC LASRKVKYRT
REEYSFRLPV PLDKATNLDE VREFQERKKA ARETGQRLPD RDIVRHKVPL QACLERFFAP
ELIEQFYSTA IDGKTNARKI TRLATMPDCL MIHVGKFTLG DDWVPKKLDV SVDMPDELDL
SNWRSAGGLQ PGEEALPEPA AEEVKFAFDE AVMSELLTMG FPPEACKRAC YHTKNSGLEA
ASNWLMEHIA DEDISEPFVV PNNSIGDCAA NQFVANPESL AMLMSMGFDE RQAVAALKAT
DGNVERATDW IFSHADSISV EEAAPASNSS AAAASSAPNK TDYRDGRGKY RLVGFISHMG
TSAQVGHYVC HIRKKGEWVI FNDSKVAKSQ NPPKDLGYLY LYMREQ
//
