GenomeNet

Database: UniProt/TrEMBL
Entry: B4IH69_DROSE
LinkDB: B4IH69_DROSE
Original site: B4IH69_DROSE 
ID   B4IH69_DROSE            Unreviewed;       610 AA.
AC   B4IH69;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-SEP-2017, entry version 74.
DE   SubName: Full=GM11800 {ECO:0000313|EMBL:EDW49245.1};
GN   Name=Dsec\GM11800 {ECO:0000313|EMBL:EDW49245.1};
GN   ORFNames=Dsec_GM11800 {ECO:0000313|EMBL:EDW49245.1}, GM11800
GN   {ECO:0000313|FlyBase:FBgn0166742};
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN   [1] {ECO:0000313|EMBL:EDW49245.1, ECO:0000313|Proteomes:UP000001292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25
RC   {ECO:0000313|Proteomes:UP000001292};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00734478};
CC   -!- SIMILARITY: Belongs to the peptidase M10A family.
CC       {ECO:0000256|SAAS:SAAS00542437}.
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DR   EMBL; CH480838; EDW49245.1; -; Genomic_DNA.
DR   RefSeq; XP_002043114.1; XM_002043078.1.
DR   ProteinModelPortal; B4IH69; -.
DR   MEROPS; M10.031; -.
DR   EnsemblMetazoa; FBtr0194785; FBpp0193277; FBgn0166742.
DR   GeneID; 6618866; -.
DR   KEGG; dse:Dsec_GM11800; -.
DR   FlyBase; FBgn0166742; Dsec\GM11800.
DR   KO; K07763; -.
DR   OMA; ITTILMC; -.
DR   OrthoDB; EOG091G03DP; -.
DR   PhylomeDB; B4IH69; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007505; P:adult fat body development; IEA:EnsemblMetazoa.
DR   GO; GO:0034769; P:basement membrane disassembly; IEA:EnsemblMetazoa.
DR   GO; GO:0007155; P:cell adhesion; IEA:EnsemblMetazoa.
DR   GO; GO:0045216; P:cell-cell junction organization; IEA:EnsemblMetazoa.
DR   GO; GO:0035001; P:dorsal trunk growth, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0097156; P:fasciculation of motor neuron axon; IEA:EnsemblMetazoa.
DR   GO; GO:0007561; P:imaginal disc eversion; IEA:EnsemblMetazoa.
DR   GO; GO:0002168; P:instar larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0007591; P:molting cycle, chitin-based cuticle; IEA:EnsemblMetazoa.
DR   GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0035071; P:salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0042246; P:tissue regeneration; IEA:EnsemblMetazoa.
DR   GO; GO:0007419; P:ventral cord development; IEA:EnsemblMetazoa.
DR   CDD; cd00094; HX; 1.
DR   CDD; cd04278; ZnMc_MMP; 1.
DR   Gene3D; 2.110.10.10; -; 2.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR000585; Hemopexin-like_dom.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR018486; Hemopexin_CS.
DR   InterPro; IPR033739; M10A_MMP.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   Pfam; PF00045; Hemopexin; 4.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   PIRSF; PIRSF001191; Peptidase_M10A_matrix; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SMART; SM00120; HX; 4.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   PROSITE; PS00024; HEMOPEXIN; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|SAAS:SAAS00710469};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001292};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00734812};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00458299};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00082048};
KW   Metalloprotease {ECO:0000256|SAAS:SAAS00473618};
KW   Protease {ECO:0000256|SAAS:SAAS00082023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW   Repeat {ECO:0000256|SAAS:SAAS00710432};
KW   Zinc {ECO:0000256|SAAS:SAAS00082033}.
FT   DOMAIN      138    295       ZnMc. {ECO:0000259|SMART:SM00235}.
FT   REPEAT      328    373       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      374    419       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      420    469       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
FT   REPEAT      470    519       Hemopexin. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01011}.
SQ   SEQUENCE   610 AA;  67463 MW;  48E2207183D6AEFF CRC64;
     MTSRRASGAT HCKTTNNSNI SNNSNKMTNC QSSVFIVVGT LFSILAAAQS APVSTTTQAE
     IYLSQFGYLP ASARNPASSG LHDQRTWVSA IEEFQSFAGL NITGELDAET MKLMSLPRCG
     VRDRVGTGDS RSKRYALQGS RWRVKNLTYK ISKYPKRLKR VDVDAEIGRA FAVWSEDTDL
     TFTRKTSGPV HIEIKFVESE HGDGDAFDGQ GGTLAHAFFP VFGGDAHFDD AELWTIGTPR
     GTNLFQVAAH EFGHSLGLSH SDQSSALMAP FYRGFEPVFK LDEDDKAAIQ SLYGRKTNQL
     RPTNVYPATT QRPYSPPKVP LDDSICKDSK VDTLFNSAQG ETYAFKGDKY YKLTTDSVEE
     GYPQLISKGW PGLPGNIDAA FTYKNGKTYF FKGTQYWRYQ GRQMDGVYPK EISEGFTGIP
     DHLDAAMVWG GNGKIYFFKG SKFWRFDPAK RPPVKASYPK PISNWEGVPN NLDAALKYTN
     GYTYFFKGDK YYRFHDARFA VDSATPPFPR PTAHWWFGCK NTPSSTGNFV DGSDNEFEQH
     SMIPHADDGN GDDFDAAVGD HQSNDEPIVP EVAERTGNGA MSQSKLTSSS AVSTVITTIL
     MCLVSKLIVS
//
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