ID   B4J2R7_DROGR            Unreviewed;      2059 AA.
AC   B4J2R7;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   19-MAR-2014, entry version 48.
DE   SubName: Full=GH16034;
GN   Name=Dgri\GH16034; ORFNames=Dgri_GH16034, GH16034;
OS   Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC   -!- SIMILARITY: Contains 1 SET domain.
CC   -!- SIMILARITY: Contains 1 post-SET domain.
CC   -!- SIMILARITY: Contains SET domain.
CC   -!- SIMILARITY: Contains post-SET domain.
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DR   EMBL; CH916366; EDV96058.1; -; Genomic_DNA.
DR   RefSeq; XP_001983710.1; XM_001983674.1.
DR   STRING; 7222.FBpp0149940; -.
DR   EnsemblMetazoa; FBtr0151448; FBpp0149940; FBgn0123505.
DR   GeneID; 6557383; -.
DR   KEGG; dgr:Dgri_GH16034; -.
DR   FlyBase; FBgn0123505; Dgri\GH16034.
DR   eggNOG; COG2940; -.
DR   InParanoid; B4J2R7; -.
DR   KO; K11423; -.
DR   OMA; CYCESAN; -.
DR   OrthoDB; EOG7DFXBB; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0018022; P:peptidyl-lysine methylation; IEA:GOC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR001202; WW_dom.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   SMART; SM00384; AT_hook; 2.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Complete proteome; Methyltransferase; Nucleus;
KW   S-adenosyl-L-methionine; Transferase.
SQ   SEQUENCE   2059 AA;  237538 MW;  47DFA13648B7995A CRC64;
     MEKLTTDANA NAAPRKRPGR PPKATSTANQ ESDVIEEVDS PQPVEERSSS PTNRRRSTRK
     KITKFDVLDV LNKSRKTHKI QIEARIDSNA PITSIAGSAA SDINRLVVAR STLPAASAPL
     VPILESFSKP KPTPSLIVAQ VSSDKSQQQT TLIRKRGRPR KAALILASDP STSVTAGADL
     QLESNDSNET STSFNLIDDA SNSSEQTLIT PIEINDEDVI TVLTSDEDSN SQIIFVDIET
     AKAAAEADEE INDQPNQTFK LIFPNAQQNH LETNTIEIEE PQQEELETQL ITEELSEPPE
     LWFEEIHKPE EQQQEEHQPE EELVQAQQQL ENKTKQQIDI EVEGEKPKSN FIEVMQQVIE
     KRMAEKKQLE IQKLQREEQL QREAKLESEA KLEREALLLK EREMEQEKML EKEKLEREKL
     QQEEKLKQEA KLEREKQLEK EKLEQEKKLE REKREREKLK QKEKLEREAM LEREKQLEKE
     KMEREKLKQE EKLEQEAKLE RDKQLEKEKQ MEKEKQLEKD KKLELEMMEQ EKLELEMMEQ
     EKQQQKEKLE REAELEKQKQ TEAKQEMERK LEREAKLEQE KKLEREKKLE LAEKLKIEAK
     LKREKKEKEK RLEIEKKLEQ EEKQRREKKM EQAKKLEREE KLEKDKKLKQ ERKPEKEQNI
     EVLSSANSPA PLSPETLSSL LEESTDNTHI IASAAQLLAF KVESPKQTLR EIELKSPVDL
     KCVVEKPVED NTSKLELRID ATELNTTPAS SACPIAKSKA ELVMPQVNEQ LLAEAKAIPL
     PKSESPEPQE TISERLKRVL PAIEEKKDEK PSRSTPNMSF KECDALFKVL DKAHSKMLYE
     QKVKKKQRKA NKKLTAAETS LAKLQLPKQS LRRNTISEEH HEEPTTPFSS SSSKAQSLEA
     AAESKPIHSS SKKSHVKKQS RKSGAGKQEN NQDNNYSNEL GNRSVSTTTN SELELPDQFD
     DIAKFIKDGE KLLERDYKQE DEQQQQQQVS AAGEDEFAQR VANLETPATT PSPSPANSSD
     DLASGVRRSH RIKQKPQGTK SSLGRGSSSS TQTPAISMEQ QLAELAHIEA SNEQFLRQEG
     LQTFQMLRDN YYRCARQVSR ENAEMQCDCF VTGDEESLGQ MRCCGDGCIN RMLMIECGPL
     CTNGERCTNK RFQQHQGWPC RVFRTEKKGC GITAELQMPS GEFIMEYVGE VIDSEEFERR
     QHLYSEDRNR HYYFMALRSD SIIDATSKGN ISRYINHSCD PNAETQKWTV NGELRIGFFS
     LKTIMPGEEI TFDYQYQRYG RDAQRCYCES ANCRGWIGNE PESDEGEQLD TETESESEEL
     QLVEQEQKTK TPKVGKTKKQ QKLPASRGKQ RKEQQPKAKD REYKAGRWLR PTGGVRAPRK
     PDQEDPDVLE QLTLLSGSGL KNQLDTLRFS RCMVRAKLLE TRLQLLGVLT RGELPCRRLF
     LDYHGLRLLH AWISESGSDK QLRLALLDAL ESLPIPNKTM LNDSRVYQSV QLWSNQLMET
     PPEVAAPAPE PDPDSEAVLA RISALLLKWN GLPEIFRIPK RERIEQMKEH EREADRQQQL
     EESNSASAVL NSDRYRQDRF RRDTSSRYEK SKPPSRMSGN NTICTITTQP KEWQGVQESA
     SGSKSDSRRR SDLDPRRATI SKELRRSLFE RKVAQDEAEK RVGSEDWREH ELRCEYFGLD
     LNTDPKLLPY CQNTETNEWF NSENVPVPVP PRCGDISEPP SPKYGDDVEY KLPPGVEPLP
     LSWHFSLTPE GDIYYYNLRD RIPQWEPPNA EQRLQKLVDD DEPLELTEPD EAANLDDLVK
     IDIDYVGTLS EKSLRQYIEV KIKERREARR NRLVSVRVIS PRREEDRVYN QQESRKYKEN
     KEKIRRRKEI YRRTRTDANP AEQPASPAGD SLPIHSYLYS SDEETITESN LPPVDALVLN
     VPDVVQPSGS TETETPPSAK RKHANVEVHK KHRDSKRKTT TVRDSNEKFH FEISGHVAEF
     LRPFRQDTCH LGRITSDEDY KFLIKRLSLH ITTKEMRYCE VTGNPLACTE SVKHKSYEFI
     KQYMRKKGPV YKKPIDRPD
//