ID B4J2R7_DROGR Unreviewed; 2059 AA.
AC B4J2R7;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 04-FEB-2015, entry version 54.
DE RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00124033};
DE EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00124033};
GN Name=Dgri\GH16034 {ECO:0000313|EMBL:EDV96058.1};
GN ORFNames=Dgri_GH16034 {ECO:0000313|EMBL:EDV96058.1}, GH16034
GN {ECO:0000313|FlyBase:FBgn0123505};
OS Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV96058.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC {ECO:0000256|SAAS:SAAS00123872}.
CC -!- SIMILARITY: Contains 1 SET domain.
CC {ECO:0000256|RuleBase:RU004538}.
CC -!- SIMILARITY: Contains 1 post-SET domain.
CC {ECO:0000256|RuleBase:RU004541}.
CC -!- SIMILARITY: Contains SET domain. {ECO:0000256|SAAS:SAAS00176750}.
CC -!- SIMILARITY: Contains post-SET domain.
CC {ECO:0000256|SAAS:SAAS00123905}.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CH916366; EDV96058.1; -; Genomic_DNA.
DR RefSeq; XP_001983710.1; XM_001983674.1.
DR STRING; 7222.FBpp0149940; -.
DR EnsemblMetazoa; FBtr0151448; FBpp0149940; FBgn0123505.
DR GeneID; 6557383; -.
DR KEGG; dgr:Dgri_GH16034; -.
DR FlyBase; FBgn0123505; Dgri\GH16034.
DR eggNOG; COG2940; -.
DR InParanoid; B4J2R7; -.
DR KO; K11423; -.
DR OMA; CYCESAN; -.
DR OrthoDB; EOG7DFXBB; -.
DR PhylomeDB; B4J2R7; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR001202; WW_dom.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR SMART; SM00384; AT_hook; 2.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000001070};
KW Methyltransferase {ECO:0000256|RuleBase:RU004541,
KW ECO:0000256|SAAS:SAAS00157756};
KW Nucleus {ECO:0000256|SAAS:SAAS00124098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00157749};
KW Transferase {ECO:0000256|RuleBase:RU004541,
KW ECO:0000256|SAAS:SAAS00157760}.
SQ SEQUENCE 2059 AA; 237538 MW; 47DFA13648B7995A CRC64;
MEKLTTDANA NAAPRKRPGR PPKATSTANQ ESDVIEEVDS PQPVEERSSS PTNRRRSTRK
KITKFDVLDV LNKSRKTHKI QIEARIDSNA PITSIAGSAA SDINRLVVAR STLPAASAPL
VPILESFSKP KPTPSLIVAQ VSSDKSQQQT TLIRKRGRPR KAALILASDP STSVTAGADL
QLESNDSNET STSFNLIDDA SNSSEQTLIT PIEINDEDVI TVLTSDEDSN SQIIFVDIET
AKAAAEADEE INDQPNQTFK LIFPNAQQNH LETNTIEIEE PQQEELETQL ITEELSEPPE
LWFEEIHKPE EQQQEEHQPE EELVQAQQQL ENKTKQQIDI EVEGEKPKSN FIEVMQQVIE
KRMAEKKQLE IQKLQREEQL QREAKLESEA KLEREALLLK EREMEQEKML EKEKLEREKL
QQEEKLKQEA KLEREKQLEK EKLEQEKKLE REKREREKLK QKEKLEREAM LEREKQLEKE
KMEREKLKQE EKLEQEAKLE RDKQLEKEKQ MEKEKQLEKD KKLELEMMEQ EKLELEMMEQ
EKQQQKEKLE REAELEKQKQ TEAKQEMERK LEREAKLEQE KKLEREKKLE LAEKLKIEAK
LKREKKEKEK RLEIEKKLEQ EEKQRREKKM EQAKKLEREE KLEKDKKLKQ ERKPEKEQNI
EVLSSANSPA PLSPETLSSL LEESTDNTHI IASAAQLLAF KVESPKQTLR EIELKSPVDL
KCVVEKPVED NTSKLELRID ATELNTTPAS SACPIAKSKA ELVMPQVNEQ LLAEAKAIPL
PKSESPEPQE TISERLKRVL PAIEEKKDEK PSRSTPNMSF KECDALFKVL DKAHSKMLYE
QKVKKKQRKA NKKLTAAETS LAKLQLPKQS LRRNTISEEH HEEPTTPFSS SSSKAQSLEA
AAESKPIHSS SKKSHVKKQS RKSGAGKQEN NQDNNYSNEL GNRSVSTTTN SELELPDQFD
DIAKFIKDGE KLLERDYKQE DEQQQQQQVS AAGEDEFAQR VANLETPATT PSPSPANSSD
DLASGVRRSH RIKQKPQGTK SSLGRGSSSS TQTPAISMEQ QLAELAHIEA SNEQFLRQEG
LQTFQMLRDN YYRCARQVSR ENAEMQCDCF VTGDEESLGQ MRCCGDGCIN RMLMIECGPL
CTNGERCTNK RFQQHQGWPC RVFRTEKKGC GITAELQMPS GEFIMEYVGE VIDSEEFERR
QHLYSEDRNR HYYFMALRSD SIIDATSKGN ISRYINHSCD PNAETQKWTV NGELRIGFFS
LKTIMPGEEI TFDYQYQRYG RDAQRCYCES ANCRGWIGNE PESDEGEQLD TETESESEEL
QLVEQEQKTK TPKVGKTKKQ QKLPASRGKQ RKEQQPKAKD REYKAGRWLR PTGGVRAPRK
PDQEDPDVLE QLTLLSGSGL KNQLDTLRFS RCMVRAKLLE TRLQLLGVLT RGELPCRRLF
LDYHGLRLLH AWISESGSDK QLRLALLDAL ESLPIPNKTM LNDSRVYQSV QLWSNQLMET
PPEVAAPAPE PDPDSEAVLA RISALLLKWN GLPEIFRIPK RERIEQMKEH EREADRQQQL
EESNSASAVL NSDRYRQDRF RRDTSSRYEK SKPPSRMSGN NTICTITTQP KEWQGVQESA
SGSKSDSRRR SDLDPRRATI SKELRRSLFE RKVAQDEAEK RVGSEDWREH ELRCEYFGLD
LNTDPKLLPY CQNTETNEWF NSENVPVPVP PRCGDISEPP SPKYGDDVEY KLPPGVEPLP
LSWHFSLTPE GDIYYYNLRD RIPQWEPPNA EQRLQKLVDD DEPLELTEPD EAANLDDLVK
IDIDYVGTLS EKSLRQYIEV KIKERREARR NRLVSVRVIS PRREEDRVYN QQESRKYKEN
KEKIRRRKEI YRRTRTDANP AEQPASPAGD SLPIHSYLYS SDEETITESN LPPVDALVLN
VPDVVQPSGS TETETPPSAK RKHANVEVHK KHRDSKRKTT TVRDSNEKFH FEISGHVAEF
LRPFRQDTCH LGRITSDEDY KFLIKRLSLH ITTKEMRYCE VTGNPLACTE SVKHKSYEFI
KQYMRKKGPV YKKPIDRPD
//
