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Database: UniProt/TrEMBL
Entry: B4K998_DROMO
LinkDB: B4K998_DROMO
Original site: B4K998_DROMO 
ID   B4K998_DROMO            Unreviewed;       396 AA.
AC   B4K998;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   26-NOV-2014, entry version 39.
DE   RecName: Full=Mannose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000611};
DE            EC=5.3.1.8 {ECO:0000256|RuleBase:RU000611};
GN   Name=Dmoj\GI22736 {ECO:0000313|EMBL:EDW15530.1};
GN   ORFNames=Dmoj_GI22736 {ECO:0000313|EMBL:EDW15530.1}, GI22736
GN   {ECO:0000313|FlyBase:FBgn0145463};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:EDW15530.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC       phosphate. {ECO:0000256|RuleBase:RU000611}.
CC   -!- COFACTOR:
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000611};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC       phosphate: step 1/2. {ECO:0000256|RuleBase:RU004248}.
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC       family. {ECO:0000256|RuleBase:RU004189}.
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DR   EMBL; CH933806; EDW15530.1; -; Genomic_DNA.
DR   RefSeq; XP_002000069.1; XM_002000033.1.
DR   EnsemblMetazoa; FBtr0173461; FBpp0171953; FBgn0145463.
DR   GeneID; 6574011; -.
DR   KEGG; dmo:Dmoj_GI22736; -.
DR   FlyBase; FBgn0145463; Dmoj\GI22736.
DR   InParanoid; B4K998; -.
DR   KO; K01809; -.
DR   OrthoDB; EOG7GTT3M; -.
DR   PhylomeDB; B4K998; -.
DR   UniPathway; UPA00126; UER00423.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR001250; Man6P_Isoase-1.
DR   InterPro; IPR016305; Mannose-6-P_Isomerase.
DR   InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR10309; PTHR10309; 1.
DR   Pfam; PF01238; PMI_typeI; 1.
DR   PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR   PRINTS; PR00714; MAN6PISMRASE.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR00218; manA; 1.
DR   PROSITE; PS00965; PMI_I_1; 1.
DR   PROSITE; PS00966; PMI_I_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Isomerase {ECO:0000256|RuleBase:RU000611};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   Zinc {ECO:0000256|RuleBase:RU000611}.
SQ   SEQUENCE   396 AA;  44721 MW;  26DE5E7D2CD7716E CRC64;
     MELTGWVKNY EWGKNGIHSA VAQLAMANDP DFVLKDDEPY AEMWMGTHFC GVSIVKETGE
     TLDRVLKMEL PYLFKVLSIK KALSIQVHPN KCEAERLHAE RPEIYKDSNH KPEMCIALTP
     FLALVGFQPI DDIIDNIDEF QPLSKLIGKE AVHELHQKRD TESLKACYEI LMRSNDAKIA
     ACLKEIAKKY KKELESNELL NVFNKINADF PGDVGVLSLF FLNLIHLKPG QGIYLGANEI
     HAYLEGDCVE CMACSDNVIR AGLTPKYKDV EQLISSVIYE GKPARCKLFM PYRIDDFVEV
     FAPPVDDFAV IHVAISHTVD TYKLEIQKYG SIMLTLTGKR IVKLTTKDGP KEITVSRGNI
     IYIPVEAAPA IEFLHTEDCG DDFSAYIATY NYFRLA
//
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