ID B4K998_DROMO Unreviewed; 396 AA.
AC B4K998;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 06-MAR-2013, entry version 30.
DE RecName: Full=Mannose-6-phosphate isomerase;
DE EC=5.3.1.8;
GN Name=GI22736; Synonyms=Dmoj\GI22736; ORFNames=Dmoj_GI22736;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC phosphate.
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC phosphate: step 1/2.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC family.
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DR EMBL; CH933806; EDW15530.1; -; Genomic_DNA.
DR RefSeq; XP_002000069.1; XM_002000033.1.
DR EnsemblMetazoa; FBtr0173461; FBpp0171953; FBgn0145463.
DR GeneID; 6574011; -.
DR KEGG; dmo:Dmoj_GI22736; -.
DR FlyBase; FBgn0145463; Dmoj\GI22736.
DR InParanoid; B4K998; -.
DR KO; K01809; -.
DR OrthoDB; EOG4J6Q69; -.
DR UniPathway; UPA00126; UER00423.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.10; -; 3.
DR InterPro; IPR001250; Man6P_Isoase-1.
DR InterPro; IPR016305; Mannose-6-P_Isomerase.
DR InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin.
DR PANTHER; PTHR10309; PTHR10309; 1.
DR Pfam; PF01238; PMI_typeI; 1.
DR PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR PRINTS; PR00714; MAN6PISMRASE.
DR SUPFAM; SSF51182; RmlC_like_cupin; 1.
DR TIGRFAMs; TIGR00218; manA; 1.
DR PROSITE; PS00965; PMI_I_1; 1.
DR PROSITE; PS00966; PMI_I_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Zinc.
SQ SEQUENCE 396 AA; 44721 MW; 26DE5E7D2CD7716E CRC64;
MELTGWVKNY EWGKNGIHSA VAQLAMANDP DFVLKDDEPY AEMWMGTHFC GVSIVKETGE
TLDRVLKMEL PYLFKVLSIK KALSIQVHPN KCEAERLHAE RPEIYKDSNH KPEMCIALTP
FLALVGFQPI DDIIDNIDEF QPLSKLIGKE AVHELHQKRD TESLKACYEI LMRSNDAKIA
ACLKEIAKKY KKELESNELL NVFNKINADF PGDVGVLSLF FLNLIHLKPG QGIYLGANEI
HAYLEGDCVE CMACSDNVIR AGLTPKYKDV EQLISSVIYE GKPARCKLFM PYRIDDFVEV
FAPPVDDFAV IHVAISHTVD TYKLEIQKYG SIMLTLTGKR IVKLTTKDGP KEITVSRGNI
IYIPVEAAPA IEFLHTEDCG DDFSAYIATY NYFRLA
//
