ID B4LCM2_DROVI Unreviewed; 2361 AA.
AC B4LCM2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Histone-lysine N-methyltransferase ash1 {ECO:0008006|Google:ProtNLM};
GN Name=Dvir\GJ11874 {ECO:0000313|EMBL:EDW69885.2};
GN ORFNames=Dvir_GJ11874 {ECO:0000313|EMBL:EDW69885.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW69885.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW69885.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH940647; EDW69885.2; -; Genomic_DNA.
DR RefSeq; XP_002047543.2; XM_002047507.2.
DR SMR; B4LCM2; -.
DR STRING; 7244.B4LCM2; -.
DR EnsemblMetazoa; FBtr0437490; FBpp0394313; FBgn0199128.
DR GeneID; 6622796; -.
DR KEGG; dvi:6622796; -.
DR eggNOG; KOG1083; Eukaryota.
DR HOGENOM; CLU_229222_0_0_1; -.
DR InParanoid; B4LCM2; -.
DR OrthoDB; 2882778at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblMetazoa.
DR GO; GO:0035097; C:histone methyltransferase complex; IEA:EnsemblMetazoa.
DR GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0035035; F:histone acetyltransferase binding; IEA:EnsemblMetazoa.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:EnsemblMetazoa.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:EnsemblMetazoa.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0018991; P:egg-laying behavior; IEA:EnsemblMetazoa.
DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; IEA:EnsemblMetazoa.
DR GO; GO:0048477; P:oogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:EnsemblMetazoa.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:EnsemblMetazoa.
DR CDD; cd04717; BAH_polybromo; 1.
DR CDD; cd15548; PHD_ASH1L; 1.
DR CDD; cd19174; SET_ASH1L; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR043319; PHD_ASH1L.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR PANTHER; PTHR46147:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00384; AT_hook; 3.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1461..1509
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1512..1628
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1636..1652
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2075..2195
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2241..2276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1684..1711
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2250..2276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2361 AA; 259475 MW; FC375AC51DD16A38 CRC64;
MSSGQNEASA AAKKEKVLEA QQRTQESGSE NEETDSITDQ SSQSKSTKSA TQFSVQRSDT
DGLRMKISAI RNPPSTTATS LTNSTATKET TKTALTTVEN SSRKKLAKVR KMSEAQELSG
CSADGKEKHR EKEKERDKML STVNTTKKIK VKRKKIAQKS SSSSSNNNNN NSKTLRKPAA
AFSSDSEDDL PLKVHMQRAP RLLLTAIGGS QGQGENHMGI SSSDNEELVR AADLVKAAIK
RVESDAEDNA SVAAGVAAAK IKQQLPQYQS TLLKDFMEKT QRLNQPGHAT SLPKAAMQPS
AAAAAAAAVN NSSSNNNTLS QPLQRKRRGR PKKLQPTVAT SAPAALPVAV PTINESADSG
VISTTPSPKM QQLLISDNAK PKIDMAYLDK RMYATAERVL YPPPRSKRRQ GNKKVNKEEL
QVDPLWRKID VNKKFRLRTV SGYKSDGGGG GGTSNTICSK ILAAKSGYVS DYGSVRHQRH
NHNSGYKSDA SCKSRYSSRS CASRRMSRAK SCGYRSDCKE SSGKSSKSLR RRRRASMLRS
GHEQATQALS DEHDQDILQL AGLSLGQSSE ESNEYISKPS LKCLPSTSAS KKYGEINRFV
ATGQYFSGAA KPTTTSVAAG ANTTTTTTTT AADNFIQGKM LLQRKHSISQ DTMLPGKSAC
KIKSRRSSAA SMCSSYVSGA SRVRRRHRRK SFSHAKSLNI DSKLLTEIDI IASTFHARCR
IQDDRLTASS GKEKLLAEAN KLQATLTAPI AATLPLLNGG GGGGSNSTTS AAATTKPLKR
ALKKRKLNEP LIDFAMLSAS AGNSNGISNN NSSSSNGAKR RHKKSSSNSG GSNSSSPDDH
KLPLKKRHYL VTTGAEVASA FASNGKLNAE AWAAAAAAAK SSANTKAQAQ FNAKKLTPKK
RHLLVSQEVA SGAAATAGSA SPLRIVVDNN SISGGKLLDI SPSSLCSLKQ QRRQGAKAKN
LLVASAGAVA RELPQQLQSP AGSSSCPPPG IFEPSVELEI QIPIAKLNES VITKSEVESP
LLAALDIKED ANKKEQCQRV LETLLHKTGG NLLLKRKRKK INRTGFPTVR RKKRKVSVEH
TLLPQQQQQQ QLEQQQQQLP ARETRSSSTL AAALTMDCER VPKTGEAQET FVARSSNQRT
PRLSVVALER LQRPQTPANS GGNARGRPRG RGRPKLQKPQ PPAPQQQQQQ SHPVAQLLEV
QPAKKRGRAA KQTELLVPRL ERKLEPSIKL PAGIDPNTNF SCKIRLKRRK TIQQEAVKQL
EPAKQPEQQL RLDVSTPLAT SDDRMQIAAE AAAKRSQQPV PASEHEPLPA QESTLNLATD
YGSCSDTSED KCSTASQRKR TKLKKNFLVA GLFSNYFKQL PAGAAATVPS TAVAVKQPNR
KATDGEQTEQ QQPQVSVLLP PPSYCERYFR RTLNDFELPY DIWWAYSHDK LPTRHVVPSW
NYRKIRTNVY AESVRPNLAG FDHPNCNCKP QASGACLDNC LNRMVYTECA PSNCPAGDKC
RNQKIQRHEV APGVERFMTA DKGWGVRTKL PIAKGTYILE YVGEVVTERE FKQRMASIYL
NDTHHYCLHL DGGLVIDGQR MGSDCRFVNH SCEPNCEMQK WSVNGLSRMV LFAKRAIEQG
EELTYDYNFS LFNPSEGQPC RCNMPQCRGV IGGKSQRIKP LPAELKTTAG AESAAAGLKE
ANGNQHGRQR KHKAKKNAQR LQQAAKEAMV VARVQQLSER EKKLVKQCNI FLVRNFEKIR
RCKAKRAAAK AQAAASPAAG DSDLPGRRPS TPSSSSLLAA QISALCTPRN MKTRGLTQAV
QDPELEKMAK MAVVLRDICT ALESLKMFDL LSTLPSSKKK KQLKTTRLDF KTIQAQVEQG
HYKTPQAYDE HMLQLFAEAR QLHGDDEGKS NALQTLLESY TQQKAANYAQ LLDILGKPEA
LHSFKPKEEE EEKVAELATA TDQSQENIKP STKVIASATP ETSAAVDVGP ELPPTDEEDV
IRCICGLYKD EGLMIQCAKC MVWQHTECTK ADIDADNYQC ERCEPREVDR EIPLDEYTEE
GHRYYLSLMR GELQVRQGDA VYVLRDIPIK DETGKVLPSQ KHTYETIGAI DYQECDIFRV
EHLWKNEAGK RFIFGHHFLR PHETFHEPSR RFYPNEVVRV SLYEVVPIEL VIGRCWVLDR
TTFCKGRPME CNDEDHCYIC ELRVDKTARF FSKAKANHPA CTKSYAFRKF PEKLKISKSY
APHDVDPSLL KTRKQKTDIE VGATPIKMSR HEQKTGQTTG NRKQRNTQAG TATGATASTQ
VPVQVLTPVA PNGQVLKKKR SRLENVLNTM KLKCLDAQTA QEQPIDLSYL LSGRGARQRK
TNCTSNGGSS SNNNNSATPC A
//
