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Database: UniProt/TrEMBL
Entry: B4LP68_DROVI
LinkDB: B4LP68_DROVI
Original site: B4LP68_DROVI 
ID   B4LP68_DROVI            Unreviewed;       682 AA.
AC   B4LP68;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   09-JUL-2014, entry version 52.
DE   RecName: Full=Protein kinase C;
DE            EC=2.7.11.13;
GN   Name=Dvir\GJ21016; ORFNames=Dvir_GJ21016, GJ21016;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC       protein kinase family. PKC subfamily.
CC   -!- SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 C2 domain.
CC   -!- SIMILARITY: Contains AGC-kinase C-terminal domain.
CC   -!- SIMILARITY: Contains protein kinase domain.
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DR   EMBL; CH940648; EDW60177.1; -; Genomic_DNA.
DR   RefSeq; XP_002048984.1; XM_002048948.1.
DR   ProteinModelPortal; B4LP68; -.
DR   STRING; 7244.FBpp0235433; -.
DR   EnsemblMetazoa; FBtr0236941; FBpp0235433; FBgn0208151.
DR   GeneID; 6625036; -.
DR   KEGG; dvi:Dvir_GJ21016; -.
DR   FlyBase; FBgn0208151; Dvir\GJ21016.
DR   eggNOG; COG0515; -.
DR   InParanoid; B4LP68; -.
DR   KO; K02677; -.
DR   OMA; PQFVHPL; -.
DR   OrthoDB; EOG77M8QM; -.
DR   PhylomeDB; B4LP68; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004697; F:protein kinase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR017892; Pkinase_C.
DR   InterPro; IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR014375; Protein_kinase_C_a/b/g.
DR   InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00433; Pkinase_C; 1.
DR   PIRSF; PIRSF000550; PKC_alpha; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Metal-binding;
KW   Nucleotide-binding; Serine/threonine-protein kinase; Transferase;
KW   Zinc; Zinc-finger.
FT   NP_BIND     359    367       ATP (By similarity).
FT   ACT_SITE    477    477       Proton acceptor (By similarity){EA18}.
FT   BINDING     382    382       ATP (By similarity).
SQ   SEQUENCE   682 AA;  78065 MW;  E5EC9E09DD06B04D CRC64;
     MSENSSDNNG DQQSQGQGAE GEAAGENKMK SRLRKGALKK KNVFNVKDHC FIARFFKQPT
     FCSHCKDFIC GYQSGYAWLG FGKQGFQCQV CSYVVHKRCH EYVTFICPGK DKGIDSDSPK
     TQHHFEPFTY AGPTFCDHCG SLLYGIYHQG LKCSACDMNV HARCKENVPS LCGCDHTERR
     GRIYLEINVK EHLLTVHIKE GRNLIPMDPN GLSDPYVKVK LIPDDKDQSK KKTRTIKACL
     NPVWNETISY DLKPEDKDRR ILIEVWDWDR TSRNDFMGAL SFGISEIIKN PTNGWFKLLT
     QDEGEYYNVP CADDQQDLLK LKQKPSQRKQ PMMRCDTHTH SQSKKDMIRA TDFNFIKVLG
     KGSFGKVLLA ERKGSEELYA IKILKKDVII QDDDVECTMI EKRVLALGEK PPFLVQLHSC
     FQTMDRLFFV MEYVNGGDLM FQIQQFGKFK EPVAVFYAAE IAAGLFFLHA KGILYRDLKL
     DNVLLDADGH VKIADFGMCK ENIMGEKTTK TFCGTPDYIA PEIILYQPYG KSVDWWAYGV
     LLYEMLVGQP PFDGEDEEEL FAAITDHNVS YPKSLSKEAK EACKGFLTKQ PNKRLGCGAS
     GEEDVRLHPF FRRIDWEKIE NREVQPPFKP KIKHRKDVSN FDKQFTSEKT DLTPTDKVFM
     MNLDQSEFVG FSYVNPEYIV SP
//
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