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Database: UniProt/TrEMBL
Entry: B4MCY6_DROVI
LinkDB: B4MCY6_DROVI
Original site: B4MCY6_DROVI 
ID   B4MCY6_DROVI            Unreviewed;       603 AA.
AC   B4MCY6;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   07-JUN-2017, entry version 63.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW58058.2};
GN   Name=Dvir\GJ15240 {ECO:0000313|EMBL:EDW58058.2};
GN   ORFNames=Dvir_GJ15240 {ECO:0000313|EMBL:EDW58058.2}, GJ15240
GN   {ECO:0000313|FlyBase:FBgn0202436};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW58058.2, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:EDW58058.2, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH940660; EDW58058.2; -; Genomic_DNA.
DR   RefSeq; XP_002058989.2; XM_002058953.2.
DR   STRING; 7244.FBpp0229657; -.
DR   EnsemblMetazoa; FBtr0231165; FBpp0229657; FBgn0202436.
DR   GeneID; 6635449; -.
DR   KEGG; dvi:Dvir_GJ15240; -.
DR   FlyBase; FBgn0202436; Dvir\GJ15240.
DR   eggNOG; KOG3571; Eukaryota.
DR   eggNOG; ENOG410Y5G4; LUCA.
DR   InParanoid; B4MCY6; -.
DR   KO; K02353; -.
DR   OrthoDB; EOG091G041O; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005112; F:Notch binding; IEA:EnsemblMetazoa.
DR   GO; GO:0070300; F:phosphatidic acid binding; IEA:EnsemblMetazoa.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR   GO; GO:0048675; P:axon extension; IEA:EnsemblMetazoa.
DR   GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0007394; P:dorsal closure, elongation of leading edge cells; IEA:EnsemblMetazoa.
DR   GO; GO:0048730; P:epidermis morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:EnsemblMetazoa.
DR   GO; GO:0090163; P:establishment of epithelial cell planar polarity; IEA:EnsemblMetazoa.
DR   GO; GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IEA:EnsemblMetazoa.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:EnsemblMetazoa.
DR   GO; GO:0042067; P:establishment of ommatidial planar polarity; IEA:EnsemblMetazoa.
DR   GO; GO:0008585; P:female gonad development; IEA:EnsemblMetazoa.
DR   GO; GO:0046847; P:filopodium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0060914; P:heart formation; IEA:EnsemblMetazoa.
DR   GO; GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0030032; P:lamellipodium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0003136; P:negative regulation of heart induction by canonical Wnt signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0045773; P:positive regulation of axon extension; IEA:EnsemblMetazoa.
DR   GO; GO:1902669; P:positive regulation of axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0032231; P:regulation of actin filament bundle assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0048076; P:regulation of compound eye pigmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0007435; P:salivary gland morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0016201; P:synaptic target inhibition; IEA:EnsemblMetazoa.
DR   GO; GO:0035309; P:wing and notum subfield formation; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008339; Dishevelled_fam.
DR   InterPro; IPR003351; Dishevelled_protein_dom.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR026542; Dsh.
DR   InterPro; IPR015506; Dsh/Dvl-rel.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR10878; PTHR10878; 1.
DR   PANTHER; PTHR10878:SF32; PTHR10878:SF32; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF02377; Dishevelled; 1.
DR   Pfam; PF00778; DIX; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   PRINTS; PR01760; DISHEVELLED.
DR   SMART; SM00021; DAX; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50841; DIX; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Wnt signaling pathway {ECO:0000256|PROSITE-ProRule:PRU00069}.
FT   DOMAIN        8     91       DIX. {ECO:0000259|PROSITE:PS50841}.
FT   DOMAIN      240    312       PDZ (DHR). {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      392    466       DEP. {ECO:0000259|PROSITE:PS50186}.
FT   COILED      117    151       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   603 AA;  67025 MW;  9DF49A47BC172A63 CRC64;
     MDTERPNSQE TKVIYHIDDE STPYLVKILI PSAQVTLKDF KMVLNKQNNN YKYFFKSMDA
     DFGVVKEEIA DDATILPCFN GRVVSWLVSA DGTNQSDNCS ELPPSECEMR VRSHLALQQQ
     QQQQQQHQQQ QQQQQHQQQQ QQQQQQQLQQ QHKLGPLQML QPPPLTYQSA SVLSSDLDST
     SLFGTESELT LDRDMTDYSS VQRLQVRKKP QRRKKRAPSM SRTSSYSSIT DSTMSLNIIT
     VSINMEAVNF LGISIVGQSN RGGDGGIYVG SIMKGGAVAL DGRIEPGDMI LQVNDVNFEN
     MTNDEAVRVL REVVQKPGPI KLVVAKCWDP NPKGYFTIPR TEPVRPIDPG AWVAHTQALT
     SHDSIMADIP EPIKERLDQN NLEEIVKAMT KPDSGLEIRD RMWLKITIPN AFIGADAVNW
     VLENVEDVQD RREARRIVSA MLRNNYIKHT VNKLTFSEQC YYVVNEERNP NMRAQLHPLA
     HALSHADTES ITSDIGPLPN PPIYMPYSAT YNPSHGYQPI QYGIAERHIS SGSSSSDVLT
     SKDISASQSD ITSVIHQTNQ LTIAAHGSNK SSGSSNRGGG GGGGGGGGGN TNDQDVSVFN
     YVL
//
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