ID   B4NSM9_DROSI            Unreviewed;       498 AA.
AC   B4NSM9;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   06-MAR-2013, entry version 31.
DE   RecName: Full=tRNA pseudouridine synthase;
DE            EC=5.4.99.-;
GN   Name=GD15210; Synonyms=Dsim\GD15210; ORFNames=Dsim_GD15210;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mixed;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC       family.
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DR   EMBL; CH982367; EDX15607.1; -; Genomic_DNA.
DR   RefSeq; XP_002076382.1; XM_002076346.1.
DR   EnsemblMetazoa; FBtr0215120; FBpp0213612; FBgn0186880.
DR   GeneID; 6739485; -.
DR   KEGG; dsi:Dsim_GD15210; -.
DR   FlyBase; FBgn0186880; Dsim\GD15210.
DR   KO; K01855; -.
DR   OrthoDB; EOG4N5TCH; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.580; -; 1.
DR   Gene3D; 3.30.70.660; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR   PANTHER; PTHR11142; PTHR11142; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
SQ   SEQUENCE   498 AA;  57603 MW;  F05A60DD21A23B1F CRC64;
     MSATNDKKVV INKRLKGLSR EALEKLTQTE LIDKVVQLEA YNFQLRNLLQ KKLSEHDKHD
     KEYSGLFGNE ADGKVSQVAK TSNKVQKIRM FDWSSAHKRH VLLKITYFGW DYQGFACQED
     SNDTIESNLF RALTRTCLIE SRATSNYHRC GRTDKEVSAF CQVISIDLRS KHPPESQLDP
     TSLSSEIDYC GLLNRVLPKN IQCVAWMPLR SPVYSARFDC VSRSYRYYFP KGDLDIAAMR
     KACDLLVRHA DFRNFCKMDV HNGVTNYMRN LQSARVEACD ENHTNSGYDM YYLEIQANAF
     LWHQIRCIMA VLLLVGQKKE KPAVISDLLD VESNPCKPQY TPAIGLPLNL FRCDFRDHTT
     RSVNHSGSGD ANEEAMDTVA NESDDLNAPE PLERDLTAWI YNEENLQKLI ENTQCEWTQF
     SVKSTMIRNV LQQLESLFEE NFKPNEKVLA QVNLLQDSVN PRQYQPLLER KRCESLENRI
     EHFVKKQRLI VKNETETE
//