ID B4RNJ6_NEIG2 Unreviewed; 174 AA.
AC B4RNJ6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 01-MAY-2013, entry version 31.
DE RecName: Full=Ribonuclease H;
DE Short=RNase H;
DE EC=3.1.26.4;
GN Name=rnhA; OrderedLocusNames=NGK_2020;
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC Neisseriaceae; Neisseria.
OX NCBI_TaxID=521006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945;
RX PubMed=18586945; DOI=10.1128/JB.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-
CC DNA hybrids (By similarity).
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC phosphomonoester.
CC -!- COFACTOR: Binds 1 magnesium ion per subunit. May bind a second
CC metal ion at a regulatory site, or after substrate binding (By
CC similarity).
CC -!- SUBUNIT: Monomer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the RNase H family.
CC -!- SIMILARITY: Contains 1 RNase H domain.
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DR EMBL; CP001050; ACF30635.1; -; Genomic_DNA.
DR RefSeq; YP_002002645.1; NC_011035.1.
DR ProteinModelPortal; B4RNJ6; -.
DR STRING; 521006.NGK_2020; -.
DR EnsemblBacteria; ACF30635; ACF30635; NGK_2020.
DR GeneID; 6449275; -.
DR KEGG; ngk:NGK_2020; -.
DR eggNOG; COG0328; -.
DR HOGENOM; HOG000040465; -.
DR KO; K03469; -.
DR OMA; MQEIEIF; -.
DR ProtClustDB; PRK00203; -.
DR BioCyc; NGON521006:GJ73-2062-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:ribonuclease H activity; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0006401; P:RNA catabolic process; IEA:HAMAP.
DR HAMAP; MF_00042; RNase_H; 1; -.
DR InterPro; IPR022892; RNaseH.
DR InterPro; IPR012337; RNaseH-like_dom.
DR InterPro; IPR002156; RNaseH_domain.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF53098; RNaseH_fold; 1.
DR PROSITE; PS50879; RNASE_H; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; Nuclease.
FT DOMAIN 30 171 RNase H (By similarity).
FT METAL 39 39 Magnesium 1 (By similarity).
FT METAL 39 39 Magnesium 2 (By similarity).
FT METAL 77 77 Magnesium 1 (By similarity).
FT METAL 99 99 Magnesium 1 (By similarity).
FT METAL 163 163 Magnesium 2 (By similarity).
SQ SEQUENCE 174 AA; 19493 MW; 66017872D99CBD2E CRC64;
MPISIRRNLS DGTTHKPLII TPDTTQRHDM DTPVYLYTDG ACKGNPGAGG WGVLMRYGSR
EKELFGGEAQ TTNNRMELTA VIEGLKSLKR RCTVIICTDS QYVKNGMENW IHGWKRNGWK
TAAKQPVKND DLWQELDALV GQHQVSWTWV KGHAGHAENE RADDLANRGA AQFS
//
