ID B4RR79_NEIG2 Unreviewed; 305 AA.
AC B4RR79;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 01-MAY-2013, entry version 39.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=thrB; OrderedLocusNames=NGK_2537;
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC Neisseriaceae; Neisseria.
OX NCBI_TaxID=521006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945;
RX PubMed=18586945; DOI=10.1128/JB.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
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DR EMBL; CP001050; ACF31137.1; -; Genomic_DNA.
DR RefSeq; YP_002003162.1; NC_011035.1.
DR STRING; 521006.NGK_2537; -.
DR EnsemblBacteria; ACF31137; ACF31137; NGK_2537.
DR GeneID; 6449613; -.
DR KEGG; ngk:NGK_2537; -.
DR PATRIC; 20343854; VBINeiGon87511_2755.
DR eggNOG; COG2334; -.
DR HOGENOM; HOG000004810; -.
DR KO; K02204; -.
DR OMA; PDNVFFL; -.
DR ProtClustDB; PRK05231; -.
DR BioCyc; NGON521006:GJ73-2610-MONOMER; -.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00301; Homoser_kinase_2; 1; -.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_ThrB.
DR InterPro; IPR011009; Kinase-like_dom.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Threonine biosynthesis; Transferase.
SQ SEQUENCE 305 AA; 33596 MW; C56B5FBF0DF4ECA3 CRC64;
MSVYTSVSDD EMRGFLSGYD LGEFVSLQGI AQGITNSNYF LTTTSGRYVL TVFEVLKQEE
LSFFLELNRH LSMKGVAVAA PVARKDGRLD SVLAGKPACL VACLKGSDTA LPTAEQCFHT
GAMLAKMHLA AADFPLEMEN PRYDAWWTEA CARLLPVLSQ DDAALLCSEI DALKDNLGNH
LPSGIIHADL FKDNVLLDGG QVSGFIDFYY ACRGNFMYDL AIAVNDWART ADNKLDEALK
KAFIGGYEGV RPLSAGEKAY FPTAQRAGCI RFWVSRLLDF HFPQAGEMTF IKDPNAFRNL
LLSLD
//
