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Database: UniProt/TrEMBL
Entry: B4U442_STREM
LinkDB: B4U442_STREM
Original site: B4U442_STREM 
ID   B4U442_STREM            Unreviewed;      1546 AA.
AC   B4U442;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   22-NOV-2017, entry version 71.
DE   SubName: Full=Sialidase NanA-like {ECO:0000313|EMBL:ACG62759.1};
GN   Name=nanA {ECO:0000313|EMBL:ACG62759.1};
GN   OrderedLocusNames=Sez_1425 {ECO:0000313|EMBL:ACG62759.1};
OS   Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=552526 {ECO:0000313|EMBL:ACG62759.1, ECO:0000313|Proteomes:UP000001873};
RN   [1] {ECO:0000313|EMBL:ACG62759.1, ECO:0000313|Proteomes:UP000001873}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGCS10565 {ECO:0000313|EMBL:ACG62759.1,
RC   ECO:0000313|Proteomes:UP000001873};
RX   PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA   Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F.,
RA   Deleo F.R., Musser J.M.;
RT   "Genome sequence of a lancefield group C Streptococcus zooepidemicus
RT   strain causing epidemic nephritis: new information about an old
RT   disease.";
RL   PLoS ONE 3:E3026-E3026(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00569680}.
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DR   EMBL; CP001129; ACG62759.1; -; Genomic_DNA.
DR   RefSeq; WP_012516021.1; NC_011134.1.
DR   ProteinModelPortal; B4U442; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH16; Glycoside Hydrolase Family 16.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   EnsemblBacteria; ACG62759; ACG62759; Sez_1425.
DR   KEGG; sez:Sez_1425; -.
DR   HOGENOM; HOG000071801; -.
DR   KO; K01186; -.
DR   OMA; ENDYELI; -.
DR   Proteomes; UP000001873; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000757; GH16.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF50939; SSF50939; 2.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS51762; GH16_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001873};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Secreted {ECO:0000256|SAAS:SAAS00085696};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     21     42       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      239    550       GH16. {ECO:0000259|PROSITE:PS51762}.
SQ   SEQUENCE   1546 AA;  170011 MW;  CB3D9929DA1A7BC1 CRC64;
     MFFNRSGQEQ VRRYAIKKLS VGVASVCVGI GLAVCLPVAV FAEDMSEASP QPPTKAAVTE
     ISHEQEPQAT DTDSEALVVS EETTVDEAVV ANAVTSNAAD QTADEEKSNA PVELNKVANG
     GFDNDYVSNK NQWQYREGGH SVLTTENNNS YAEVTSGTLD EHILQKVSTT VGKTYTLEAD
     VKVEAATPHN GLYLTAKESN HNLQGPVIKE VSLTDTDGTW SHIKLSFTAT TSETFIGLVK
     WLEASSPEAL AASASIDNVS VVEENDYELI WEDEFSGDRL NQENWGYELG SIRGNEQQHY
     TDSTENVYLE NGNLVLNVTE RKGEDRYANP RGGTSARQVI YDSGSVRTVG KQEFLYGRIE
     ARAKLPKGKG AFPAFWTLGA DFTLDGDIAS TQGYGWPSTG ELDIMELIGA PNGEHEGELA
     EGDQSNKTVY GTPHFYYVKG DADKDGSYSP TALGGNLTLS DDFYDDYHIF GINWYPDKIE
     WYVDGIVYNT MYLTGDERLE AAAAAFNKPQ YLQFNLATGG NWSKNAGYYL ASDETAFVID
     YVRYYQDAEQ KAASEAYYAS QPDLKGVKDL TMLEGTSPDL AQEVTTDQEG YVVDFSIENE
     YLFTNKGGNT NATLQASGRN DLAALSELAP GIYNIYYSAV PEAANLGSTV TPTAKIAREV
     AILTVLPKEG LYGQKGEPLS TVALPTNWQW VTPEEILGSA EHYQIKYTTE GGRAVYTTIE
     ASYIADQPSS DEQSILVDLG NAILDATAEK AAVTDDEVLS KLDDVMSLNQ GTVTIRYRLD
     TADTTVRSAA PLALLSISNQ ASAKEYASFF IEPKNNKIGL EFKGAEVPIV KVGSGFNLLT
     NSDWQTISYV FTGSRLKIYL NGDLYGEADF AGFMKQLPWK ASADTVTVGG LSRSYDGESA
     FHWGLKGLVD QVLIDTDVYD LTDIAKAHQS TLRQVTGEKL NVWDKYDEGV FEYRIPSVVK
     TPSGTLIAAA DARKKHYNDW GDIATVVRIS HDDGKTWSNN ITVLDMPTQP YFTTQYSLAD
     WNTNMTQSAC SIDSTLLTDA SGKLYLLVDV FPESQGAVAS KAGSGYEWIN GQYYLNLYDF
     DNHKYTVREE GIVYDSNGKK TDMYVDEGNF ETAFSTRGNL YQTGAGEDIL LGNIYLRSGR
     TKQGITREGS QTAPLFTYMT SFLWLLTSED EGQTWSTPLD VTPQIKEDWM GFLGTGAAAG
     IEIDAVNAEG EQVKRLVFPI YYTNQQNATS ASLGRQSSAN IFSDDGGQTW QRGESPNDGR
     IYGHNQQTTS KDFDTSVTEL TENQIIQLNN GHLLQFMRNT GKTIVIARST DYGATWDDNP
     TITDLPEPYV NLSAIHMMVD GKEYVVLSNP LGEPSGEQLT IRNQRMKGIL RVGEVLEDDS
     IDWVASTIFE PKRFAYSSLV QLDDERVGLL YEYSGQITYS TFNIKQMISD QFREDKAEIE
     EVTITSAAPK QSGKASITIQ MTFNQPMFIL GDRQLAVTVN GVDKLASYVS GDGTDTAIFE
     LSLESMPEGP ITVLPQFDHT IVETKYGIRL TDDKTYTLSY PDPATA
//
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