ID B5DE16_XENTR Unreviewed; 1436 AA.
AC B5DE16;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Homeobox protein cut-like {ECO:0000256|RuleBase:RU361129};
GN Name=cux2 {ECO:0000313|EMBL:AAI68490.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI68490.1};
RN [1] {ECO:0000313|EMBL:AAI68490.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI68490.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR EMBL; BC168490; AAI68490.1; -; mRNA.
DR RefSeq; NP_001128286.2; NM_001134814.2.
DR RefSeq; NP_001231882.1; NM_001244953.1.
DR GeneID; 100038096; -.
DR KEGG; xtr:100038096; -.
DR AGR; Xenbase:XB-GENE-487236; -.
DR CTD; 23316; -.
DR OrthoDB; 74668at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 3.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR PANTHER; PTHR14043:SF5; HOMEOBOX PROTEIN CUT-LIKE 2; 1.
DR Pfam; PF02376; CUT; 3.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 3.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 3.
DR PROSITE; PS51042; CUT; 3.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|RuleBase:RU361129};
KW Transcription regulation {ECO:0000256|RuleBase:RU361129}.
FT DOMAIN 486..573
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 832..919
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 982..1069
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1110..1170
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1112..1171
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 356..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 141..214
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 251..296
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1405..1432
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 356..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1436 AA; 160657 MW; 0AD5AC9DBB203C5A CRC64;
MVTPVLKSFQ AEVVALSKRS KEAEAAFLSV YKQLIEAPDP APLLEAARGL EDRLQQLQRI
DPENKAVKEI SRHWKKYSDF LSAAKERKEG TVPAGIPLQR EEAWHCTINS KLFSTDTFQQ
RSEAESEKGL QEAQITLAVR LGEAEEKIKV LHSALKTTQR ELLDLRCQYD KETASKTDEV
GMIMTNLEKA NRRAEAAQRE VESLREQLSS VNNSIRLTCC SPQASSGDKD SFSLCSGSHL
EAALAVKDRE ILRLLKDIQH FQNSIQELEE SSANQIAELE QQLVIKTEAI EKLEEKLRRQ
SDYEEIKTEL SILKAMKSAS ANCTISQENS TPEDSLLIEK ETFFPSQTYV LEKQRILPSN
EEDQSEDDSM KQSLGAERPY SSSPRTSFQT RDGVVTPSSS QCLQEAAAHV GQRTISSTFP
NTSEQLPGEV PLKKHMVSPV LKSENNTMLS FPSSFYSVKS TILPNHLSAT VNNDSSPLSD
QSEASSSSSA DEEHIDTSEI AFQVKEQLLK HNIGQRVFGH YVLGLSQGSV SEILARPKPW
RKLTVKGKEP FIKMKQFLSD EQNVLALRTI QVRQRGSITP RIRTPETGSD DAIKNILEQA
KKEIQSQKGG DTKGSNAPLS SSSSITSSSE DAIKSILEQA RREMQAQQQV LLEIESGNGH
RSMNTPPAER PILTPSTHNA AHIHIKQEEG TFITSAASIQ TPLSVLSPAA FVQNIIRKVK
SEIGDAGSYF DQHWATERNL LSRPLMSVSP SLSSSSSSYS GMINGRPWRR ADTCETAPSE
EEITTAEEAH KVVEVKTEAG NLDQQNMNRL SYYPAYVPRN LKPTVPPLTP EQYEMYMYRE
VDTLDLTRQV KEKLAKNGIC QRIFGEKVLG LSQGSVSDML SRPKPWSKLT QKGREPFIRM
QLWLTDQLGQ GITQQPALSQ GTLSPSETHS SPSPSPSPPE QEKSPLLILS LESTKENLQP
ESRPASSLSG RSFPNHQATG IQEMVAMSPE LDTYSITKKV KEVLTDNNLG QRLFGESILG
LTQGSVSDLL SRPKPWHKLS LKGREPFVRM QLWLSDPHNI ERLRDMKKME KKAYLKRRYG
LISGGSDSES SNTKTECASP SPQPQEYSHL QMKKPRVVLG LEEKEALKKA YQLEPYPSQQ
TIEQLSFQLN LKTNTVINWF HNYRSRMRRE ILIEGQQDND TDQEPSSCDS FTSVCTLHRD
PALHSLASEG VDRKPVVCDM DHLMHNDGCT EERVATREIK KENIEEGEEE KDDSSKRCDS
CSSEHTLCCE TDPSRMHRED EAAQHCVDLQ RPHYLRRSSS FYDKLRPSSA HDCSHKEITN
PERSQTDPIS FKSTAESSRS SLEVSLNSPS AASSPGLMMS VSPVPTSSAP ISPSLPNTVS
VKLHKLNTAS DNAPLHLSIK HSPNNQRRNE KMANLNNIIH RLERAANKEE TLEWEF
//
