ID   B5QYG4_SALEP            Unreviewed;       533 AA.
AC   B5QYG4;
DT   04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 1.
DT   01-MAY-2013, entry version 38.
DE   RecName: Full=Malate synthase;
DE            EC=2.3.3.9;
GN   Name=aceB; OrderedLocusNames=SEN3965;
OS   Salmonella enteritidis PT4 (strain P125109).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P125109;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K.,
RA   Moule S., Mungall K., Sanders M., Whitehead S., Chabalgoity J.A.,
RA   Maskell D., Humphrey T., Roberts M., Barrow P.A., Dougan G.,
RA   Parkhill J.;
RT   "Comparative genome analysis of Salmonella Enteritidis PT4 and
RT   Salmonella Gallinarum 287/91 provides insights into evolutionary and
RT   host adaptation pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + glyoxylate = (S)-malate +
CC       CoA.
CC   -!- PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate
CC       from isocitrate: step 2/2.
CC   -!- SIMILARITY: Belongs to the malate synthase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AM933172; CAR35534.1; -; Genomic_DNA.
DR   RefSeq; YP_002246008.1; NC_011294.1.
DR   ProteinModelPortal; B5QYG4; -.
DR   STRING; 550537.SEN3965; -.
DR   GeneID; 6949603; -.
DR   KEGG; set:SEN3965; -.
DR   PATRIC; 32338665; VBISalEnt14964_4048.
DR   eggNOG; COG2225; -.
DR   HOGENOM; HOG000238464; -.
DR   KO; K01638; -.
DR   OMA; GFDGTWV; -.
DR   ProtClustDB; PRK09255; -.
DR   BioCyc; SENT550537:GJFI-4037-MONOMER; -.
DR   UniPathway; UPA00703; UER00720.
DR   GO; GO:0004474; F:malate synthase activity; IEA:EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR011076; Malate_synth-like.
DR   InterPro; IPR006252; Malate_synthA.
DR   InterPro; IPR001465; Malate_synthase.
DR   InterPro; IPR019830; Malate_synthase_CS.
DR   PANTHER; PTHR21631:SF1; PTHR21631:SF1; 1.
DR   Pfam; PF01274; Malate_synthase; 1.
DR   PIRSF; PIRSF001363; Malate_synth; 1.
DR   SUPFAM; SSF51645; Malat_synth_like; 1.
DR   TIGRFAMs; TIGR01344; malate_syn_A; 1.
DR   PROSITE; PS00510; MALATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Glyoxylate bypass; Transferase;
KW   Tricarboxylic acid cycle.
FT   ACT_SITE    166    166       Proton acceptor (By similarity).
FT   ACT_SITE    447    447       Proton donor (By similarity).
SQ   SEQUENCE   533 AA;  60353 MW;  786EF10B2D067EBE CRC64;
     MNPQATTTDE LTFTRPQGEL EKQVLTAEAV EFLTELVTRF TPKRNKLLAA RIQQQQDIDN
     GKLPDFISET TSIRESNWQI RGIPADLQDR RVEITGPVER KMVINALNAN VKVFMADFED
     SLAPDWNKVI DGQINLRDAV NGTISYTNEA GKIYQLKPDP AVLICRVRGL HLPEKHVTWR
     GEAIPGSLFD FALYFFHNYK ALLAKGSGPY FYLPKTQAWQ EAAWWSEVFS YAEDRFNLPR
     GTIKATLLIE TLPAVFQMDE ILHALRDHIV GLNCGRWDYI FSYIKTLKNH PDRVLPDRQV
     VTMDKPFLSA YSRLLIKTCH KRGAFAMGGM AAFIPSKDVE RNNQVLAKVK ADKALEANNG
     HDGTWIAHPG LADTAMAVFN EVLGEHKNQL FITRDEDAPI TAEQLLEPCE GERTEAGMRA
     NIRVAVQYIE AWISGNGCVP IYGLMEDAAT AEISRTSIWQ WIHHEKTLSN GKPVTKALFR
     EMLAEEMRVI QDELGEHRYS SGRFDDAARL MEQITTSDDL IDFLTLPGYR LLA
//