ID B5X0S9_SALSA Unreviewed; 540 AA.
AC B5X0S9;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN Name=AL7A1 {ECO:0000313|EMBL:ACI32910.1};
GN Synonyms=al7a1 {ECO:0000313|RefSeq:NP_001133255.1}, aldh7a1
GN {ECO:0000313|RefSeq:NP_001133255.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI32910.1};
RN [1] {ECO:0000313|EMBL:ACI32910.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI32910.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI32910.1, ECO:0000313|RefSeq:NP_001133255.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI32910.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI32910.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI32910.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001133255.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28867386;
RA Liu P.F., Du Y., Meng L., Li X., Liu Y.;
RT "ALDH7A1 is a protein that protects Atlantic salmon against Aeromonas
RT salmonicida at the early stages of infection.";
RL Fish Shellfish Immunol. 70:30-39(2017).
RN [5] {ECO:0000313|RefSeq:NP_001133255.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; BT044648; ACI32910.1; -; mRNA.
DR RefSeq; NP_001133255.1; NM_001139783.1.
DR STRING; 8030.ENSSSAP00000029172; -.
DR PaxDb; 8030-ENSSSAP00000029172; -.
DR GeneID; 100194754; -.
DR KEGG; sasa:100194754; -.
DR CTD; 501; -.
DR OrthoDB; 8449at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR CDD; cd07130; ALDH_F7_AASADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 65..520
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 540 AA; 58866 MW; 2B5749EFACBDD374 CRC64;
MQRCFTLTIV RHWALRKKLL TISYQQSAAM STLLINQPKY AWLKELGLSE DNDGVYNGNW
GGKGEVITSY CPANNEPIAR VRQATMAEYE ETVQKSRDAW KVWADIPAPK RGEIVRQIGD
ALRKKIKVLG SLVSLEMGKI YVEGVGEVQE YVDVCDYAVG LSRMIGGPVL PSERPGHALI
EMWNPVGLVG IITAFNFPVA VYGWNNAIAL ICGNVCLWKG APTTPLTSVA VTKIVAEVLE
QNNLPGAICS MTCGGADIGT AMSKDERVDL VSFTGSTHVG KMVAMMVQER FGRNLLELGG
NNAIIVFEDA DLNLVVPSAV FASVGTAGQR CTTTRRLMLH GSIHDIVVER VAKAYKQVRI
GDPWDPSTMY GPLHTKQAVD QYLAAIEQAK QQGGTVVCGG KVMDRPGNYV EPTIITGLAH
DAPIVHTETF VPILYVLKFQ TEEEAFAWNN EVKQGLSSSI FTKDMGRVFR WLGPKGSDCG
IVNVNIPTSG AEIGGAFGGE KHTGGGRESG SDSWKQYMRR STCTINYSKD LPLAQGIKFE
//
