ID B5YCM2_DICT6 Unreviewed; 537 AA.
AC B5YCM2;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Alkaline phosphatase III {ECO:0000313|EMBL:ACI18383.1};
DE EC=3.1.3.1 {ECO:0000313|EMBL:ACI18383.1};
GN OrderedLocusNames=DICTH_0398 {ECO:0000313|EMBL:ACI18383.1};
OS Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12).
OC Bacteria; Dictyoglomota; Dictyoglomia; Dictyoglomales; Dictyoglomaceae;
OC Dictyoglomus.
OX NCBI_TaxID=309799 {ECO:0000313|EMBL:ACI18383.1, ECO:0000313|Proteomes:UP000001733};
RN [1] {ECO:0000313|EMBL:ACI18383.1, ECO:0000313|Proteomes:UP000001733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35947 / DSM 3960 / H-6-12
RC {ECO:0000313|Proteomes:UP000001733};
RX PubMed=24558247;
RA Coil D.A., Badger J.H., Forberger H.C., Riggs F., Madupu R., Fedorova N.,
RA Ward N., Robb F.T., Eisen J.A.;
RT "Complete Genome Sequence of the Extreme Thermophile Dictyoglomus
RT thermophilum H-6-12.";
RL Genome Announc. 2:e00109-e00114(2014).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 1 Mg(2+) ion. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 2 Zn(2+) ions. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- SIMILARITY: Belongs to the alkaline phosphatase family.
CC {ECO:0000256|RuleBase:RU003946}.
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DR EMBL; CP001146; ACI18383.1; -; Genomic_DNA.
DR RefSeq; WP_012547015.1; NC_011297.1.
DR AlphaFoldDB; B5YCM2; -.
DR STRING; 309799.DICTH_0398; -.
DR PaxDb; 309799-DICTH_0398; -.
DR KEGG; dth:DICTH_0398; -.
DR eggNOG; COG1785; Bacteria.
DR HOGENOM; CLU_008539_5_0_0; -.
DR OrthoDB; 9794455at2; -.
DR Proteomes; UP000001733; Chromosome.
DR GO; GO:0004035; F:alkaline phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16012; ALP; 1.
DR Gene3D; 1.10.60.40; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR001952; Alkaline_phosphatase.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR PANTHER; PTHR11596; ALKALINE PHOSPHATASE; 1.
DR PANTHER; PTHR11596:SF5; ALKALINE PHOSPHATASE; 1.
DR Pfam; PF00245; Alk_phosphatase; 1.
DR PRINTS; PR00113; ALKPHPHTASE.
DR SMART; SM00098; alkPPc; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ACI18383.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR601952-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601952-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Zinc {ECO:0000256|PIRSR:PIRSR601952-2}.
FT ACT_SITE 101
FT /note="Phosphoserine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
FT BINDING 52
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 52
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 153
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 155
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 281
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 286
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 329
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 330
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 481
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
SQ SEQUENCE 537 AA; 60083 MW; 8D12869AF31F3270 CRC64;
MRFDRVFSKV LLIFILVLGF VFFSSSFGVA LQSSSSLYKG KPVKYIFWFI GDGMGLNHVY
LTEAFLGRKS NSPSIEKLSF TQFPNVGLMT TYAADSYITD SASAITAMAA GKKTNDGVIN
MDPTLKFKYK SVAEEARDLG YKVGVLTSVS IDHATPAGMY AHQPSRNNYY AIALELFESN
FDYFGGGGFL QPQGKDGKQK DVYEIAKEKG YKIVDKIEDF LKLRKGDNKI VAINPILDSS
KALPYAINRL RGANLGLSLA DFTKKAIELL DNPKGFFIMV EGGKIDWAAH ANDAGSVIYD
VLDFNEAIKV ALEFYKKRPF ETVIIVTADH ETGGLSIGYA GTRYEVYLDV LSRQKISYDE
FTKVVNEYKS KVKREEAKLS DLLPQIKEYY GLEILSPEVR KELENRAKAG DKEAKIRLQL
ALNESEIEEL EKAFKLSMMD PKERPNDAKS YLLYGGYDPL TITVTRILNQ KAGISWTSYS
HTGMPVPVYA IGAGSYIFNG YYDNTDLYKK LMSLIGKDPY KDNVLSSAEV RELVFSK
//
