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Database: UniProt/TrEMBL
Entry: B6J602_COXB1
LinkDB: B6J602_COXB1
Original site: B6J602_COXB1 
ID   B6J602_COXB1            Unreviewed;       200 AA.
AC   B6J602;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   19-FEB-2014, entry version 35.
DE   RecName: Full=Non-canonical purine NTP pyrophosphatase;
DE            EC=3.6.1.19;
DE   AltName: Full=Non-standard purine NTP pyrophosphatase;
DE   AltName: Full=Nucleoside-triphosphate diphosphatase;
DE   AltName: Full=Nucleoside-triphosphate pyrophosphatase;
GN   OrderedLocusNames=CbuK_1988;
OS   Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain
OS   Q154)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Coxiellaceae; Coxiella.
OX   NCBI_TaxID=434924;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CbuK_Q154;
RX   PubMed=19047403; DOI=10.1128/IAI.01141-08;
RA   Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D.,
RA   Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F.,
RA   Samuel J.E., Heinzen R.A.;
RT   "Comparative genomics reveal extensive transposon-mediated genomic
RT   plasticity and diversity among potential effector proteins within the
RT   genus Coxiella.";
RL   Infect. Immun. 77:642-656(2009).
CC   -!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine
CC       nucleotides such as XTP and ITP/dITP to their respective
CC       monophosphate derivatives. Might exclude non-canonical purines
CC       from DNA precursor pool, thus preventing their incorporation into
CC       DNA and avoiding chromosomal lesions (By similarity).
CC   -!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
CC       nucleotide + diphosphate.
CC   -!- COFACTOR: Binds 1 divalent metal cation ion per subunit; can use
CC       either magnesium or manganese (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the HAM1 NTPase family.
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DR   EMBL; CP001020; ACJ21093.1; -; Genomic_DNA.
DR   RefSeq; YP_002306238.1; NC_011528.1.
DR   ProteinModelPortal; B6J602; -.
DR   SMR; B6J602; 1-195.
DR   STRING; 434924.CbuK_1988; -.
DR   EnsemblBacteria; ACJ21093; ACJ21093; CbuK_1988.
DR   GeneID; 7016501; -.
DR   KEGG; cbc:CbuK_1988; -.
DR   PATRIC; 17919423; VBICoxBur77120_1988.
DR   eggNOG; COG0127; -.
DR   HOGENOM; HOG000293319; -.
DR   KO; K02428; -.
DR   OrthoDB; EOG6CZQQP; -.
DR   ProtClustDB; PRK00120; -.
DR   BioCyc; CBUR434924:GHWU-1983-MONOMER; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
DR   GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:InterPro.
DR   GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01405; Non_canon_purine_NTPase; 1.
DR   InterPro; IPR002637; Ham1p-like.
DR   InterPro; IPR020922; NTPase.
DR   PANTHER; PTHR11067; PTHR11067; 1.
DR   Pfam; PF01725; Ham1p_like; 1.
DR   TIGRFAMs; TIGR00042; TIGR00042; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding;
KW   Nucleotide metabolism; Nucleotide-binding.
FT   REGION        8     13       Substrate binding (By similarity).
FT   REGION       69     70       Substrate binding (By similarity).
FT   METAL        40     40       Magnesium or manganese (By similarity).
FT   METAL        69     69       Magnesium or manganese (By similarity).
FT   BINDING     157    157       Substrate (By similarity).
FT   BINDING     177    177       Substrate (By similarity).
FT   BINDING     183    183       Substrate (By similarity).
SQ   SEQUENCE   200 AA;  21777 MW;  A35DF16EE7025113 CRC64;
     MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA IIKARHAAKQ
     TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ KVLEALEAAD DSDRSASFHC
     VIALMENEND PAPLICHGVW EGEIAREPRG KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI
     SHRGQALEQL STVLTEAFLV
//
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