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Database: UniProt/TrEMBL
Entry: B6VCA2_DANRE
LinkDB: B6VCA2_DANRE
Original site: B6VCA2_DANRE 
ID   B6VCA2_DANRE            Unreviewed;       646 AA.
AC   B6VCA2;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   25-OCT-2017, entry version 67.
DE   SubName: Full=Prohormone convertase 2 {ECO:0000313|EMBL:ACJ05353.1};
GN   Name=pcsk2 {ECO:0000313|EMBL:ACJ05353.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-090608-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:ACJ05353.1};
RN   [1] {ECO:0000313|EMBL:ACJ05353.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19332069; DOI=10.1016/j.ygcen.2009.03.013;
RA   Morash M.G., MacDonald A.B., Croll R.P., Anini Y.;
RT   "Molecular cloning, ontogeny and tissue distribution of zebrafish
RT   (Danio rerio) prohormone convertases: pcsk1 and pcsk2.";
RL   Gen. Comp. Endocrinol. 162:179-187(2009).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS00679558}.
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DR   EMBL; FJ373315; ACJ05353.1; -; mRNA.
DR   RefSeq; NP_001135738.1; NM_001142266.1.
DR   UniGene; Dr.24063; -.
DR   ProteinModelPortal; B6VCA2; -.
DR   MEROPS; S08.073; -.
DR   PaxDb; B6VCA2; -.
DR   GeneID; 100004460; -.
DR   KEGG; dre:100004460; -.
DR   CTD; 5126; -.
DR   ZFIN; ZDB-GENE-090608-1; pcsk2.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; KOG3526; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   HOGENOM; HOG000192536; -.
DR   HOVERGEN; HBG008705; -.
DR   KO; K01360; -.
DR   PhylomeDB; B6VCA2; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd04059; Peptidases_S8_Protein_converta; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR009020; Peptidase/Inhibitor_I9.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR002884; PrprotnconvertsP.
DR   InterPro; IPR032815; S8_pro-domain.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   SUPFAM; SSF54897; SSF54897; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912743};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912730};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS00912691}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    646       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002851172.
FT   DOMAIN       37    115       S8_pro-domain. {ECO:0000259|Pfam:
FT                                PF16470}.
FT   DOMAIN      164    426       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   DOMAIN      510    597       P_proprotein. {ECO:0000259|Pfam:PF01483}.
SQ   SEQUENCE   646 AA;  71779 MW;  CF37C4FAA24E3523 CRC64;
     MRRFRGHHRT APALFLTLIG ALMMSAAAED ELFITGHFLV QMREAAPEDA QKLALEHGFE
     SARKLPFGED LFHFYPLEMP KTRRKRSLHQ QHHRLASDHR VKNVFPQEGF GRQKRGYRDL
     PNTDVNMSDP LFTKQWYLIN TGQADGTPGL DLNVAEAWSL GFTGKGVTIA IMDDGIDYLH
     PDLASNYNAE ASFDFSSNDP YPYPRYTDDW FNSHGTRCAG EVSAVSNNNI CGVGVAYNSK
     VAGIRMLDQP FMTDIIEASS ISHMPQVIDI YSASWGPTDD GKTVDGPREL TLQAMADGVN
     KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD ESCSSTLAST
     FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF ALALEANPNL TWRDLQHLTV
     LTSKRNKLHD EVHQWRRNGV GLEFNHLFGY GVLDAGGMVK LARDWKTVPE RFHCVAGSMQ
     DIHKIQSGNK LLLSISTDAC QGKDNFVRYL EHVQAVITVN ASRRGDLNIN MTSPMGTKSI
     LLSRRPRDDD AKVGFDKWPF MTTHTWGEDP RGPWLLEVGF QSQSDMQSGL LKEWTLMLHG
     TQSAPYIDQV VRDYQSKLAM SKKEELEEEL DEAVERSLKS LLSKNN
//
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