ID B7FQ66_PHATC Unreviewed; 501 AA.
AC B7FQ66;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 03-APR-2013, entry version 29.
DE SubName: Full=Serine hydroxymethyltransferase;
GN Name=SHMT2; ORFNames=PHATRDRAFT_54015;
OS Phaeodactylum tricornutum (strain CCAP 1055/1).
OC Eukaryota; Stramenopiles; Bacillariophyta; Bacillariophyceae;
OC Bacillariophycidae; Naviculales; Phaeodactylaceae; Phaeodactylum.
OX NCBI_TaxID=556484;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1055/1;
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E.,
RA Salamov A., Vandepoele K., Beszteri B., Gruber A., Heijde M.,
RA Katinka M., Mock T., Valentin K., Verret F., Berges J.A., Brownlee C.,
RA Cadoret J.P., Chiovitti A., Choi C.J., Coesel S., De Martino A.,
RA Detter J.C., Durkin C., Falciatore A., Fournet J., Haruta M.,
RA Huysman M.J., Jenkins B.D., Jiroutova K., Jorgensen R.E., Joubert Y.,
RA Kaplan A., Kroger N., Kroth P.G., La Roche J., Lindquist E.,
RA Lommer M., Martin-Jezequel V., Lopez P.J., Lucas S., Mangogna M.,
RA McGinnis K., Medlin L.K., Montsant A., Oudot-Le Secq M.P., Napoli C.,
RA Obornik M., Parker M.S., Petit J.L., Porcel B.M., Poulsen N.,
RA Robison M., Rychlewski L., Rynearson T.A., Schmutz J., Shapiro H.,
RA Siaut M., Stanley M., Sussman M.R., Taylor A.R., Vardi A.,
RA von Dassow P., Vyverman W., Willis A., Wyrwicz L.S., Rokhsar D.S.,
RA Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=CCAP 1055/1;
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A.,
RA Detter J.C., Lindquist E., Shapiro H., Lucas S., Glavina del Rio T.,
RA Pitluck S., Rokhsar D., Bowler C.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Interconversion of serine and glycine (By similarity).
CC -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine +
CC H(2)O = tetrahydrofolate + L-serine.
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC -!- SIMILARITY: Belongs to the SHMT family.
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DR EMBL; CM000605; EEC51803.1; -; Genomic_DNA.
DR RefSeq; XP_002177340.1; XM_002177304.1.
DR UniGene; Ptc.4964; -.
DR ProteinModelPortal; B7FQ66; -.
DR STRING; 2850.JGI54015; -.
DR EnsemblProtists; Phatr54015; Phatr54015; Phatr54015.
DR GeneID; 7196206; -.
DR KEGG; pti:PHATRDRAFT_54015; -.
DR HOGENOM; HOG000239405; -.
DR KO; K00600; -.
DR ProtClustDB; PLN03226; -.
DR UniPathway; UPA00193; -.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006544; P:glycine metabolic process; IEA:InterPro.
DR GO; GO:0006563; P:L-serine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_00051; SHMT; 1; -.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_major_sub2.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR PANTHER; PTHR11680; PTHR11680; 1.
DR Pfam; PF00464; SHMT; 1.
DR PIRSF; PIRSF000412; SHMT; 1.
DR SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW Complete proteome; Methyltransferase; One-carbon metabolism;
KW Pyridoxal phosphate; Reference proteome; Transferase.
SQ SEQUENCE 501 AA; 54921 MW; 7336AD2BEF841EC2 CRC64;
MLSVRSTLAP AIRRIATRTF AAGADLNKTL LETDPELSQL IEQEKARQRN SLVLIASENF
TSKAVLDALG SVLSNKYSEG YPGARYYGGN ENIDQVELLC QKRALEAFHL DPAEWGVNVQ
SLSGSPANFQ VYTALLETHA RILALDLPHG GHLSHGYQTA TKKISMVSRY FESMPYRLDE
STGTIDYDQM EKSADLFRPK MIVAGASAYS RLIDYERIRK IADGVGAYVM SDMAHISGLV
AAQVIPSCFE YSDVVTTTTH KSLRGPRGAM IFYRKGQKGT DKKGNPIMYD LEEKINFTVF
PGLQGGPHNH TIGALATCLK QAATADFVVY QKQVLKNSSR LAEELNKLGY TLVSGGTDNH
LVLIDVKSSA KIDGARVERI LELACIATNK NTVPGDTSAL MPGGIRMGTP ALTSRGFKED
DFTKVAHFFD RAVKIAVKLK NTDQGAKLKG FREMCAVGPS VDADLVQLRH DVSEFACLFP
TVGFNEDEMT FEGEYNVDFV A
//
