ID B7KP86_METC4 Unreviewed; 244 AA.
AC B7KP86;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 29-MAY-2013, entry version 28.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Mchl_4562;
OS Methylobacterium extorquens (strain CM4 / NCIMB 13688)
OS (Methylobacterium chloromethanicum).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=440085;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM4 / NCIMB 13688;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T.,
RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT CM4.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP001298; ACK85338.1; -; Genomic_DNA.
DR RefSeq; YP_002423266.1; NC_011757.1.
DR ProteinModelPortal; B7KP86; -.
DR STRING; 440085.Mchl_4562; -.
DR EnsemblBacteria; ACK85338; ACK85338; Mchl_4562.
DR GeneID; 7117957; -.
DR KEGG; mch:Mchl_4562; -.
DR PATRIC; 22503408; VBIMetChl132133_4520.
DR eggNOG; COG0125; -.
DR HOGENOM; HOG000229078; -.
DR KO; K00943; -.
DR OMA; ITLEGPE; -.
DR ProtClustDB; CLSK2332037; -.
DR BioCyc; MCHL440085:GCXT-4631-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 15 22 ATP (By similarity).
SQ SEQUENCE 244 AA; 26171 MW; 65260D263AD7683B CRC64;
MSSDAPRGVF ITFEGGEGAG KSTQIARLAE TLRRVSGREV VTTREPGGTE RAEALRAALL
RGVAKPYGPF AEALMFAAAR IDHIENLIRP ALDRGAIVLC DRFSDSTRAY QGAAGGLDPA
LIDSLERVTL VDLRPDLTLI LDLPPEAGLA RARRRGAGEP ADRFEAEGMR FHERLRTAFR
SIAEAEPERC RVIDADLGPD AVETAIATAI AARWPDLLPP AGEGQGQEGK NREGKDREGQ
GHAA
//
