ID B7MI72_ECO45 Unreviewed; 810 AA.
AC B7MI72;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 01-MAY-2013, entry version 33.
DE SubName: Full=Fused aspartokinase II homoserine dehydrogenase II;
DE EC=1.1.1.3;
DE EC=2.7.2.4;
GN Name=metL; OrderedLocusNames=ECS88_4391;
OS Escherichia coli O45:K1 (strain S88 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585035;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S88 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A.,
RA Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M.,
RA Dossat C., Karoui M.E., Frapy E., Garry L., Ghigo J.M., Gilles A.M.,
RA Johnson J., Le Bouguenec C., Lescat M., Mangenot S.,
RA Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A.,
RA Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B.,
RA Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
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DR EMBL; CU928161; CAR05570.1; -; Genomic_DNA.
DR RefSeq; YP_002393920.1; NC_011742.1.
DR ProteinModelPortal; B7MI72; -.
DR STRING; 585035.ECS88_4391; -.
DR EnsemblBacteria; CAR05570; CAR05570; ECS88_4391.
DR GeneID; 7128811; -.
DR KEGG; ecz:ECS88_4391; -.
DR PATRIC; 18416467; VBIEscCol91599_4307.
DR eggNOG; COG0527; -.
DR HOGENOM; HOG000271594; -.
DR KO; K12525; -.
DR OMA; GRDMQRK; -.
DR ProtClustDB; PRK09466; -.
DR BioCyc; ECOL585035:GJWP-4368-MONOMER; -.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009067; P:aspartate family amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.1160.10; -; 2.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR InterPro; IPR001341; Asp_kinase_dom.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR InterPro; IPR001342; HDH_cat.
DR InterPro; IPR019811; HDH_CS.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF00742; Homoserine_dh; 1.
DR Pfam; PF03447; NAD_binding_3; 1.
DR PIRSF; PIRSF000727; ThrA; 1.
DR SUPFAM; SSF53633; Aa_kinase; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
DR PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE 4: Predicted;
KW Complete proteome; Kinase; Oxidoreductase; Transferase.
SQ SEQUENCE 810 AA; 88886 MW; 29ACDD057B0E6559 CRC64;
MSVIAQAGAK GRQLHKFGGS SLADVKCYLR VAGIMAEYSQ PDDMMVVSAA GSTTNQLINW
LKLSQTDRLS AHQVQQTLRR YQCDLISGLL PAEEADNLIS AFVSDLEHLA ALLDSGINDA
VYAEVVGHGE VWSARLMSAV LNQQGLPAAW LDAREFLRAE RAAQPQVDEG LSYPLLQQLL
VQHPGKRLVV TGFISRNNAG ETVLLGRNGS DYSATQIGAL AGVSRVTIWS DVAGVYSADP
RKVKDACLLP LLRLDEASEL ARLAAPVLHA RTLQPVSGSE IDLQLRCSYT PDQGSTRIER
VLASGTGARI VTSHDDVCLI EFQVPASQDF KLAHKEIDQI LKRAQVRPLA VGVHNDRQLL
QFCYTSEVAD SALKILDEAG LPGELRLRQG LALVAMVGAG VTRNPLHCHR FWQQLKGQPV
EFTWQSDDGI SLVAVLRTGP TESLIQGLHQ SVFRAEKRIG LVLFGKGNIG SRWLELFARE
QSTLSARTGF EFVLAGVVDS RRSLLSYDGL DASRALAFFN DEAVEQDEES LFLWMRAHPY
DDLVVLDVTA SQQLADQYLD FASHGFHVIS ANKLAGASDS NKYRQIHDAF EKTGRHWLYN
ATVGAGLPIN HTVRDLIDSG DTILSISGIF SGTLSWLFLQ FDGSVPFTEL VDQAWQQGLT
EPDPRDDLSG KDVMRKLVIL AREAGYNIES DQVRVESLVP AHCEGGSIDH FFENGDELNE
QMVQRLEAAR EMGLVLRYVA RFDANGKARV GVEAVREDHP LASLLPCDNV FAIESRWYRD
NPLVIRGPGA GRDVTAGAIQ SDINRLAQLL
//
