ID B7PR98_IXOSC Unreviewed; 279 AA.
AC B7PR98;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Glutathione S-transferase, putative {ECO:0000313|EMBL:EEC09120.1, ECO:0000313|EnsemblMetazoa:ISCW005803-PA};
DE EC=2.5.1.18 {ECO:0000313|EMBL:EEC09120.1};
GN ORFNames=IscW_ISCW005803 {ECO:0000313|EMBL:EEC09120.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC09120.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC09120.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW005803-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005803-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010959996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS771185; EEC09120.1; -; Genomic_DNA.
DR RefSeq; XP_002436290.1; XM_002436245.1.
DR AlphaFoldDB; B7PR98; -.
DR STRING; 6945.B7PR98; -.
DR PaxDb; 6945-B7PR98; -.
DR EnsemblMetazoa; ISCW005803-RA; ISCW005803-PA; ISCW005803.
DR KEGG; isc:IscW_ISCW005803; -.
DR VEuPathDB; VectorBase:ISCI005803; -.
DR VEuPathDB; VectorBase:ISCP_008601; -.
DR VEuPathDB; VectorBase:ISCW005803; -.
DR HOGENOM; CLU_011226_2_1_1; -.
DR InParanoid; B7PR98; -.
DR OMA; RAIAMYL; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR CDD; cd03177; GST_C_Delta_Epsilon; 1.
DR CDD; cd03045; GST_N_Delta_Epsilon; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43969; GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR43969:SF9; GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01153; Main.4:_Theta-like; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PR98};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC09120.1}.
FT DOMAIN 51..132
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 138..258
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 30711 MW; 8FC46286A6854650 CRC64;
MRAVGDCLRG LHPGRGALNE PPLSASEGAS KGERTTDRAA VVSDSHRRPA MPVDLYFTTG
SPPCTFVRVL AKKLGVPLTP HKIDLMAKEQ LKPEFVKLNP QHTVPTINDN GFVLWESRAI
AMYLLDKYAP DSPLYPKDIQ KRALVNRLVF FESGSFYQAQ MGYFRPRWFK GQEPGGDLKE
TYDKALANAV TLLGDNQFLA GDTLTLADVG LVCSLGIAIE GAEYEGMDQF PKLIEYYGRV
KAALPEYDEE AAEPVGLIRQ MIARAKSGQK VHGPPTDSK
//
