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Database: UniProt/TrEMBL
Entry: B8HEP5_PSECP
LinkDB: B8HEP5_PSECP
Original site: B8HEP5_PSECP 
ID   B8HEP5_PSECP            Unreviewed;       739 AA.
AC   B8HEP5;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   25-OCT-2017, entry version 62.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ACL39161.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ACL39161.1};
GN   OrderedLocusNames=Achl_1170 {ECO:0000313|EMBL:ACL39161.1};
OS   Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 /
OS   CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter
OS   chlorophenolicus).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae;
OC   Pseudarthrobacter.
OX   NCBI_TaxID=452863 {ECO:0000313|EMBL:ACL39161.1, ECO:0000313|Proteomes:UP000002505};
RN   [1] {ECO:0000313|EMBL:ACL39161.1, ECO:0000313|Proteomes:UP000002505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 /
RC   NCIMB 13794 / A6 {ECO:0000313|Proteomes:UP000002505};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Arthrobacter chlorophenolicus
RT   A6.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP001341; ACL39161.1; -; Genomic_DNA.
DR   RefSeq; WP_015936384.1; NC_011886.1.
DR   ProteinModelPortal; B8HEP5; -.
DR   STRING; 452863.Achl_1170; -.
DR   EnsemblBacteria; ACL39161; ACL39161; Achl_1170.
DR   KEGG; ach:Achl_1170; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000002505; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002505};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ACL39161.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002505}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79449 MW;  F0BF669C45F6C3A0 CRC64;
     MSKIIYTHTD EAPMLATYSF LPIIEAFAST AGVEVETRDI SLAGRIIAVF GDYLTPEQQT
     GDALAELGEL AKTPEANIIK LPNISASIPQ LKAAIAELQG QGYALPDYPD NPSSDEETAV
     RSRYDKIKGS AVNPVLREGN SDRRAPLSVK NYARQNPHSM GAWTADSKTN VATMGQNDFR
     SNEKSVVIES EGTIAIQLVR EDGSVKVLKK AFPVLAGEVI DGTVMRAAAL DEFLKDQVAR
     AKEEGVLFSA HLKATMMKVS DPIIFGHVVK AYFSELFDTY GKQLAAAGIS PNNGLAAILS
     SLEDLPADVR DGVQNLIKKG LEDGPALAMV DSDKGITTLN VPSDVIVDAS MPAMIRSSGH
     MWGPDGKEAD TLAVLPDSSY AGIYQVVIDD CRANGAYDPT TMGTVPNVGL MAQAAEEYGS
     HDKTFEIQET GTVQVVDGTG NVLIEHEVSE GDIWRACQTK DAPIRDWVKL AVTRARASQT
     PAVFWLDEER AHDANLIAKV NEYLKDHDIE GLDLQILSPV KATAFTLERI RKGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LLKENHLRWD
     SLGEFLALAV SFEHLATTTG NARAQVLADT LDRATGTFLL ENKSPSRRAG ELDNRGSHYF
     LARYWAEELA KQTDDADLAA AFGAVATELS SQEEAIVGEL AAVQGSPVDV GGYYHPEDAK
     ASAVMRPSAT LNKVIDSLS
//
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