ID B8N4V5_ASPFN Unreviewed; 461 AA.
AC B8N4V5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 03-APR-2013, entry version 30.
DE RecName: Full=Mannose-6-phosphate isomerase;
DE EC=5.3.1.8;
GN ORFNames=AFLA_018140;
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM
OS 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC mitosporic Trichocomaceae; Aspergillus.
OX NCBI_TaxID=332952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167;
RA Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A.,
RA Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J.,
RA Bhatnagar D., Cleveland T.E.;
RT "Genome sequence of Aspergillus flavus strain NRRL 3357.";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC phosphate.
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC phosphate: step 1/2.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC family.
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DR EMBL; EQ963474; EED54562.1; -; Genomic_DNA.
DR RefSeq; XP_002375834.1; XM_002375793.1.
DR STRING; 5059.CADAFLAP00003699; -.
DR EnsemblFungi; CADAFLAT00003699; CADAFLAP00003699; CADAFLAG00003699.
DR GeneID; 7911493; -.
DR KEGG; afv:AFLA_018140; -.
DR HOGENOM; HOG000241277; -.
DR KO; K01809; -.
DR UniPathway; UPA00126; UER00423.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.10; -; 3.
DR InterPro; IPR001250; Man6P_Isoase-1.
DR InterPro; IPR016305; Mannose-6-P_Isomerase.
DR InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin.
DR PANTHER; PTHR10309; PTHR10309; 1.
DR Pfam; PF01238; PMI_typeI; 1.
DR PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR PRINTS; PR00714; MAN6PISMRASE.
DR SUPFAM; SSF51182; RmlC_like_cupin; 1.
DR TIGRFAMs; TIGR00218; manA; 1.
DR PROSITE; PS00965; PMI_I_1; 1.
DR PROSITE; PS00966; PMI_I_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Zinc.
SQ SEQUENCE 461 AA; 50079 MW; FAFA65DCF5B550CA CRC64;
MQVPLLRLQC GVNSYDWGKI GQESAAARYA ATTAAPDFSI ESEKPYAELW MGTHPSLPSK
DVETQRTLLD MVQDNQALLS KEVSEKYGGK LPFLFKVLSV NKALSIQAHP NKKLAEKLHA
RDPRNYPDDN HKPEMTIAIT PFEGLCGFRP LAEISHFLNA VAPLRQLIGT DAVDQFLGAV
KGSEDSEDPT VMQKNKDALR IVFTALMNSS SENIEAATKE LTAAAQNSPE TFGTSASTPE
TNPSNPAELA AVITRLNGQF PNDIGLFVFF FLNFVKLAPG EAMFLKADDI HAYVSGDIIE
CMASSDNVVR AGFTPKFKDV DTLTDMLTYS YAPIEEQKLE PKEYPYAILN ASAYSSASSS
MLYDPPIEEF SVVKTDLKRT GAKATFDALG GPSILICTGG TGKITVGHKT EEVKEGYVFF
VGADAECIIE NTGSGADEGN VFTTFKAFCD LTGKEDMVNG H
//
