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Database: UniProt/TrEMBL
Entry: B8N4V5_ASPFN
LinkDB: B8N4V5_ASPFN
Original site: B8N4V5_ASPFN 
ID   B8N4V5_ASPFN            Unreviewed;       461 AA.
AC   B8N4V5;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   26-NOV-2014, entry version 35.
DE   RecName: Full=Mannose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000611};
DE            EC=5.3.1.8 {ECO:0000256|RuleBase:RU000611};
GN   ORFNames=AFLA_018140 {ECO:0000313|EMBL:EED54562.1};
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM
OS   12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=332952 {ECO:0000313|Proteomes:UP000001875};
RN   [1] {ECO:0000313|Proteomes:UP000001875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
RC   {ECO:0000313|Proteomes:UP000001875};
RA   Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A.,
RA   Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J.,
RA   Bhatnagar D., Cleveland T.E.;
RT   "Genome sequence of Aspergillus flavus strain NRRL 3357.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC       phosphate. {ECO:0000256|RuleBase:RU000611}.
CC   -!- COFACTOR:
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000611};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC       phosphate: step 1/2. {ECO:0000256|RuleBase:RU004248}.
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC       family. {ECO:0000256|RuleBase:RU004189}.
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DR   EMBL; EQ963474; EED54562.1; -; Genomic_DNA.
DR   RefSeq; XP_002375834.1; XM_002375793.1.
DR   STRING; 5059.CADAFLAP00003699; -.
DR   EnsemblFungi; CADAFLAT00003699; CADAFLAP00003699; CADAFLAG00003699.
DR   GeneID; 7911493; -.
DR   KEGG; afv:AFLA_018140; -.
DR   HOGENOM; HOG000241277; -.
DR   KO; K01809; -.
DR   OMA; PYAEFWV; -.
DR   OrthoDB; EOG7WDNCR; -.
DR   UniPathway; UPA00126; UER00423.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR001250; Man6P_Isoase-1.
DR   InterPro; IPR016305; Mannose-6-P_Isomerase.
DR   InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   PANTHER; PTHR10309; PTHR10309; 1.
DR   Pfam; PF01238; PMI_typeI; 1.
DR   PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR   PRINTS; PR00714; MAN6PISMRASE.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR00218; manA; 1.
DR   PROSITE; PS00965; PMI_I_1; 1.
DR   PROSITE; PS00966; PMI_I_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001875};
KW   Isomerase {ECO:0000256|RuleBase:RU000611,
KW   ECO:0000313|EMBL:EED54562.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001875};
KW   Zinc {ECO:0000256|RuleBase:RU000611}.
SQ   SEQUENCE   461 AA;  50079 MW;  FAFA65DCF5B550CA CRC64;
     MQVPLLRLQC GVNSYDWGKI GQESAAARYA ATTAAPDFSI ESEKPYAELW MGTHPSLPSK
     DVETQRTLLD MVQDNQALLS KEVSEKYGGK LPFLFKVLSV NKALSIQAHP NKKLAEKLHA
     RDPRNYPDDN HKPEMTIAIT PFEGLCGFRP LAEISHFLNA VAPLRQLIGT DAVDQFLGAV
     KGSEDSEDPT VMQKNKDALR IVFTALMNSS SENIEAATKE LTAAAQNSPE TFGTSASTPE
     TNPSNPAELA AVITRLNGQF PNDIGLFVFF FLNFVKLAPG EAMFLKADDI HAYVSGDIIE
     CMASSDNVVR AGFTPKFKDV DTLTDMLTYS YAPIEEQKLE PKEYPYAILN ASAYSSASSS
     MLYDPPIEEF SVVKTDLKRT GAKATFDALG GPSILICTGG TGKITVGHKT EEVKEGYVFF
     VGADAECIIE NTGSGADEGN VFTTFKAFCD LTGKEDMVNG H
//
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