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Database: UniProt/TrEMBL
Entry: B8NJN7_ASPFN
LinkDB: B8NJN7_ASPFN
Original site: B8NJN7_ASPFN 
ID   B8NJN7_ASPFN            Unreviewed;       502 AA.
AC   B8NJN7;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   05-JUL-2017, entry version 57.
DE   SubName: Full=Histone-lysine N-methyltransferase Clr4 {ECO:0000313|EMBL:EED50025.1};
GN   ORFNames=AFLA_068470 {ECO:0000313|EMBL:EED50025.1};
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM
OS   12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=332952 {ECO:0000313|EMBL:EED50025.1, ECO:0000313|Proteomes:UP000001875};
RN   [1] {ECO:0000313|EMBL:EED50025.1, ECO:0000313|Proteomes:UP000001875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
RC   {ECO:0000313|Proteomes:UP000001875};
RX   PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; EQ963479; EED50025.1; -; Genomic_DNA.
DR   RefSeq; XP_002380406.1; XM_002380365.1.
DR   STRING; 5059.CADAFLAP00008271; -.
DR   EnsemblFungi; EED50025; EED50025; AFLA_068470.
DR   GeneID; 7921605; -.
DR   KEGG; afv:AFLA_068470; -.
DR   EuPathDB; FungiDB:AFLA_068470; -.
DR   HOGENOM; HOG000207341; -.
DR   KO; K11419; -.
DR   OMA; FIDCYLG; -.
DR   OrthoDB; EOG092C2EWO; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001875};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EED50025.1};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001875};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EED50025.1}.
FT   DOMAIN      263    336       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      339    466       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      478    494       Post-SET. {ECO:0000259|PROSITE:PS50868}.
SQ   SEQUENCE   502 AA;  55775 MW;  3427B24F2B2D7E2E CRC64;
     MPVKMVIDLT GDSDSEDQIR SQLHSNIQSA TPTFFTHLAH RTPSSSVPLK RKSERSPESE
     LYDSFFNFKR KPSAPSVESS AASSSVPHQN NLPNGSTIAT TKLQSSTPSP SPVIKEQSLP
     ARAISVVVPS PSSQLKKEIE SAKWASSSQS CTPELKGVLE KFYPTNAHVE RGRKGAYPAA
     RKVNRAAIPL PTGTPGPILQ KRPEALDQQY RTLERKLSTI KGPKITFAPA DGPKLAKVTA
     NFQFINSYKL HKGVSPAPAE FIGGCSCGKH CDPERCPCSE KEDDSTENII PYQRAKDRPD
     LLVLTPEFLR RTAMIFECGA QCACDKSCWN RVVQRGRTVE LEIFYTGNRG FGLRSPRYIR
     EGQFIDCYLG EVITKQHADI REETAVKNGH SYLFGLDFSP EVDEEDIYVV DGQRFGCATR
     FMNHSCKPNC RMFTVTNTIG DERLYNLAFF ALKDIPPMTE LTFDYNPGTE RSEKVDSSVV
     ACLCGEDNCR GQLWPSKRKG TK
//
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